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O78208

- O78208_HUMAN

UniProt

O78208 - O78208_HUMAN

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Protein
Submitted name:

Protein 41

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cytokine receptor activity Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Ensembl
  3. chaperone mediated protein folding requiring cofactor Source: Ensembl
  4. defense response Source: Ensembl
  5. immunoglobulin mediated immune response Source: Ensembl
  6. intracellular protein transport Source: Ensembl
  7. macrophage migration inhibitory factor signaling pathway Source: Ensembl
  8. negative regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
  9. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  10. negative regulation of mature B cell apoptotic process Source: Ensembl
  11. negative regulation of T cell differentiation Source: Ensembl
  12. negative thymic T cell selection Source: Ensembl
  13. positive regulation of chemokine (C-X-C motif) ligand 2 production Source: Ensembl
  14. positive regulation of cytokine-mediated signaling pathway Source: Ensembl
  15. positive regulation of dendritic cell antigen processing and presentation Source: Ensembl
  16. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  17. positive regulation of macrophage cytokine production Source: Ensembl
  18. positive regulation of neutrophil chemotaxis Source: Ensembl
  19. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  20. positive regulation of T cell differentiation Source: Ensembl
  21. positive regulation of type 2 immune response Source: Ensembl
  22. positive thymic T cell selection Source: Ensembl
  23. protein complex assembly Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Protein 41Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. external side of plasma membrane Source: Ensembl
  3. Golgi apparatus Source: Ensembl
  4. lysosome Source: Ensembl
  5. macrophage migration inhibitory factor receptor complex Source: Ensembl
  6. MHC class II protein complex Source: Ensembl
  7. multivesicular body Source: Ensembl
  8. NOS2-CD74 complex Source: Ensembl
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiO78208.

Expressioni

Gene expression databases

BgeeiO78208.
ExpressionAtlasiO78208. baseline and differential.

Family & Domainsi

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR022339. MHC_II-assoc_invar_chain.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR14093. PTHR14093. 1 hit.
PfamiPF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57610. SSF57610. 1 hit.
PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

O78208-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
PPKVLTKCQE EVSHIPAVHP GSFRPKCDEN GNYLPLQCYG SIGYCWCVFP
60 70
NGTEVPNTRS RGHHNCSESL E
Length:71
Mass (Da):7,916
Last modified:November 1, 1998 - v1
Checksum:iABFC8EC5571D3C48
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei71 – 711Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28590 mRNA. Translation: AAA35996.1.
PIRiI70687.
S40464. E27011.
UniGeneiHs.436568.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28590 mRNA. Translation: AAA35996.1 .
PIRi I70687.
S40464. E27011.
UniGenei Hs.436568.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O78208.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

Bgeei O78208.
ExpressionAtlasi O78208. baseline and differential.

Family and domain databases

Gene3Di 4.10.800.10. 1 hit.
InterProi IPR022339. MHC_II-assoc_invar_chain.
IPR000716. Thyroglobulin_1.
[Graphical view ]
PANTHERi PTHR14093. PTHR14093. 1 hit.
Pfami PF00086. Thyroglobulin_1. 1 hit.
[Graphical view ]
SMARTi SM00211. TY. 1 hit.
[Graphical view ]
SUPFAMi SSF57610. SSF57610. 1 hit.
PROSITEi PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Four Ia invariant chain forms derive from a single gene by alternate splicing and alternate initiation of transcription/translation."
    O'Sullivan D.M., Noonan D., Quaranta V.
    J. Exp. Med. 166:444-460(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Purification of the complex of cathepsin L and the MHC class II-associated invariant chain fragment from human kidney."
    Ogrinc T., Dolenc I., Ritonja A., Turk V.
    FEBS Lett. 336:555-559(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.

Entry informationi

Entry nameiO78208_HUMAN
AccessioniPrimary (citable) accession number: O78208
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.