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O78208

- O78208_HUMAN

UniProt

O78208 - O78208_HUMAN

Protein
Submitted name:

Protein 41

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. cytokine receptor activity Source: Ensembl

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Ensembl
    3. chaperone mediated protein folding requiring cofactor Source: Ensembl
    4. defense response Source: Ensembl
    5. immunoglobulin mediated immune response Source: Ensembl
    6. intracellular protein transport Source: Ensembl
    7. macrophage migration inhibitory factor signaling pathway Source: Ensembl
    8. negative regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
    9. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
    10. negative regulation of mature B cell apoptotic process Source: Ensembl
    11. negative regulation of T cell differentiation Source: Ensembl
    12. negative thymic T cell selection Source: Ensembl
    13. positive regulation of chemokine (C-X-C motif) ligand 2 production Source: Ensembl
    14. positive regulation of cytokine-mediated signaling pathway Source: Ensembl
    15. positive regulation of dendritic cell antigen processing and presentation Source: Ensembl
    16. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    17. positive regulation of macrophage cytokine production Source: Ensembl
    18. positive regulation of neutrophil chemotaxis Source: Ensembl
    19. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    20. positive regulation of T cell differentiation Source: Ensembl
    21. positive regulation of type 2 immune response Source: Ensembl
    22. positive thymic T cell selection Source: Ensembl
    23. protein complex assembly Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein 41Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. external side of plasma membrane Source: Ensembl
    3. Golgi apparatus Source: Ensembl
    4. lysosome Source: Ensembl
    5. macrophage migration inhibitory factor receptor complex Source: Ensembl
    6. MHC class II protein complex Source: Ensembl
    7. multivesicular body Source: Ensembl
    8. NOS2-CD74 complex Source: Ensembl

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Proteomic databases

    PRIDEiO78208.

    Expressioni

    Gene expression databases

    ArrayExpressiO78208.
    BgeeiO78208.

    Family & Domainsi

    Family and domain databases

    Gene3Di4.10.800.10. 1 hit.
    InterProiIPR022339. MHC_II-assoc_invar_chain.
    IPR000716. Thyroglobulin_1.
    [Graphical view]
    PANTHERiPTHR14093. PTHR14093. 1 hit.
    PfamiPF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    SMARTiSM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57610. SSF57610. 1 hit.
    PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    O78208-1 [UniParc]FASTAAdd to Basket

    « Hide

    PPKVLTKCQE EVSHIPAVHP GSFRPKCDEN GNYLPLQCYG SIGYCWCVFP   50
    NGTEVPNTRS RGHHNCSESL E 71
    Length:71
    Mass (Da):7,916
    Last modified:November 1, 1998 - v1
    Checksum:iABFC8EC5571D3C48
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei71 – 711Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28590 mRNA. Translation: AAA35996.1.
    PIRiI70687.
    S40464. E27011.
    UniGeneiHs.436568.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28590 mRNA. Translation: AAA35996.1 .
    PIRi I70687.
    S40464. E27011.
    UniGenei Hs.436568.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O78208.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi O78208.
    Bgeei O78208.

    Family and domain databases

    Gene3Di 4.10.800.10. 1 hit.
    InterProi IPR022339. MHC_II-assoc_invar_chain.
    IPR000716. Thyroglobulin_1.
    [Graphical view ]
    PANTHERi PTHR14093. PTHR14093. 1 hit.
    Pfami PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    SMARTi SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57610. SSF57610. 1 hit.
    PROSITEi PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Four Ia invariant chain forms derive from a single gene by alternate splicing and alternate initiation of transcription/translation."
      O'Sullivan D.M., Noonan D., Quaranta V.
      J. Exp. Med. 166:444-460(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Purification of the complex of cathepsin L and the MHC class II-associated invariant chain fragment from human kidney."
      Ogrinc T., Dolenc I., Ritonja A., Turk V.
      FEBS Lett. 336:555-559(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiO78208_HUMAN
    AccessioniPrimary (citable) accession number: O78208
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1998
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.