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Protein
Submitted name:

Protein 41

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cytokine receptor activity Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Ensembl
  3. chaperone mediated protein folding requiring cofactor Source: Ensembl
  4. defense response Source: Ensembl
  5. immunoglobulin mediated immune response Source: Ensembl
  6. intracellular protein transport Source: Ensembl
  7. macrophage migration inhibitory factor signaling pathway Source: Ensembl
  8. negative regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
  9. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  10. negative regulation of mature B cell apoptotic process Source: Ensembl
  11. negative regulation of T cell differentiation Source: Ensembl
  12. negative thymic T cell selection Source: Ensembl
  13. positive regulation of chemokine (C-X-C motif) ligand 2 production Source: Ensembl
  14. positive regulation of cytokine-mediated signaling pathway Source: Ensembl
  15. positive regulation of dendritic cell antigen processing and presentation Source: Ensembl
  16. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  17. positive regulation of macrophage cytokine production Source: Ensembl
  18. positive regulation of neutrophil chemotaxis Source: Ensembl
  19. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  20. positive regulation of T cell differentiation Source: Ensembl
  21. positive regulation of type 2 immune response Source: Ensembl
  22. positive thymic T cell selection Source: Ensembl
  23. protein complex assembly Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Protein 41Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. external side of plasma membrane Source: Ensembl
  3. Golgi apparatus Source: Ensembl
  4. lysosome Source: Ensembl
  5. macrophage migration inhibitory factor receptor complex Source: Ensembl
  6. MHC class II protein complex Source: Ensembl
  7. multivesicular body Source: Ensembl
  8. NOS2-CD74 complex Source: Ensembl
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiO78208.

Expressioni

Gene expression databases

BgeeiO78208.
ExpressionAtlasiO78208. baseline and differential.

Interactioni

Family & Domainsi

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR022339. MHC_II-assoc_invar_chain.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR14093. PTHR14093. 1 hit.
PfamiPF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57610. SSF57610. 1 hit.
PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

O78208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PPKVLTKCQE EVSHIPAVHP GSFRPKCDEN GNYLPLQCYG SIGYCWCVFP
60 70
NGTEVPNTRS RGHHNCSESL E
Length:71
Mass (Da):7,916
Last modified:November 1, 1998 - v1
Checksum:iABFC8EC5571D3C48
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei71 – 711Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28590 mRNA. Translation: AAA35996.1.
PIRiI70687.
S40464. E27011.
UniGeneiHs.436568.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28590 mRNA. Translation: AAA35996.1.
PIRiI70687.
S40464. E27011.
UniGeneiHs.436568.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiO78208.

Proteomic databases

PRIDEiO78208.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Gene expression databases

BgeeiO78208.
ExpressionAtlasiO78208. baseline and differential.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR022339. MHC_II-assoc_invar_chain.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR14093. PTHR14093. 1 hit.
PfamiPF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57610. SSF57610. 1 hit.
PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Four Ia invariant chain forms derive from a single gene by alternate splicing and alternate initiation of transcription/translation."
    O'Sullivan D.M., Noonan D., Quaranta V.
    J. Exp. Med. 166:444-460(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Purification of the complex of cathepsin L and the MHC class II-associated invariant chain fragment from human kidney."
    Ogrinc T., Dolenc I., Ritonja A., Turk V.
    FEBS Lett. 336:555-559(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.

Entry informationi

Entry nameiO78208_HUMAN
AccessioniPrimary (citable) accession number: O78208
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.