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Protein
Submitted name:

H-2 class II histocompatibility antigen, I-A beta chain

Gene

H2-Eb1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-MMU-202424. Downstream TCR signaling.
R-MMU-202427. Phosphorylation of CD3 and TCR zeta chains.
R-MMU-202430. Translocation of ZAP-70 to Immunological synapse.
R-MMU-202433. Generation of second messenger molecules.
R-MMU-2132295. MHC class II antigen presentation.
R-MMU-389948. PD-1 signaling.
R-MMU-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
H-2 class II histocompatibility antigen, I-A beta chainImported
Submitted name:
Major histocompatibility protein class II beta chainImported
Gene namesi
Name:H2-Eb1Imported
Synonyms:Btnl2Imported, IEbetaImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95901. H2-Eb1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei226 – 248HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500877864627 – 264Sequence analysisAdd BLAST238

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000060586.

Interactioni

Protein-protein interaction databases

MINTiMINT-4105399.
STRINGi10090.ENSMUSP00000074143.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 214Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST91

Sequence similaritiesi

Belongs to the MHC class II family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.
GeneTreeiENSGT00760000118970.
HOVERGENiHBG012730.
KOiK06752.
OMAiNCEISEG.
OrthoDBiEOG091G15IU.
TreeFamiTF336626.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O78196-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWLPRVPCV AAVILLLTVL SPPVALVRDS RPWFLEYCKS ECHFYNGTQR
60 70 80 90 100
VRLLERYFYN LEENLRFDSD VGEFRAVTEL GRPDAENWNS QPEFLEQKRA
110 120 130 140 150
EVDTVCRHNY EISDKFLVRR RVEPTVTVYP TKTQPLEHHN LLVCSVSDFY
160 170 180 190 200
PGNIEVRWFR NGKEEKTGIV STGLVRNGDW TFQTLVMLET VPQSGEVYTC
210 220 230 240 250
QVEHPSLTDP VTVEWKAQST SAQNKMLSGV GGFVLGLLFL GAGLFIYFRN
260
QKGQSGLQPT GLLS
Length:264
Mass (Da):30,153
Last modified:November 1, 1998 - v1
Checksum:i25B9632404172BCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974422 Genomic DNA. No translation available.
AF050157 Genomic DNA. Translation: AAC05286.1.
AK160485 mRNA. Translation: BAE35816.1.
RefSeqiNP_034512.2. NM_010382.2.
UniGeneiMm.22564.

Genome annotation databases

EnsembliENSMUST00000074557; ENSMUSP00000074143; ENSMUSG00000060586.
GeneIDi14969.
KEGGimmu:14969.
UCSCiuc008cch.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974422 Genomic DNA. No translation available.
AF050157 Genomic DNA. Translation: AAC05286.1.
AK160485 mRNA. Translation: BAE35816.1.
RefSeqiNP_034512.2. NM_010382.2.
UniGeneiMm.22564.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4105399.
STRINGi10090.ENSMUSP00000074143.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074557; ENSMUSP00000074143; ENSMUSG00000060586.
GeneIDi14969.
KEGGimmu:14969.
UCSCiuc008cch.1. mouse.

Organism-specific databases

CTDi14969.
MGIiMGI:95901. H2-Eb1.

Phylogenomic databases

eggNOGiENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.
GeneTreeiENSGT00760000118970.
HOVERGENiHBG012730.
KOiK06752.
OMAiNCEISEG.
OrthoDBiEOG091G15IU.
TreeFamiTF336626.

Enzyme and pathway databases

ReactomeiR-MMU-202424. Downstream TCR signaling.
R-MMU-202427. Phosphorylation of CD3 and TCR zeta chains.
R-MMU-202430. Translocation of ZAP-70 to Immunological synapse.
R-MMU-202433. Generation of second messenger molecules.
R-MMU-2132295. MHC class II antigen presentation.
R-MMU-389948. PD-1 signaling.
R-MMU-877300. Interferon gamma signaling.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060586.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO78196_MOUSE
AccessioniPrimary (citable) accession number: O78196
Secondary accession number(s): F6VX29
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.