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Protein
Submitted name:

MHC class I HLA-A

Gene

MHC class I HLA-A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the presentation of foreign antigens to the immune system.SAAS annotation

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I HLA-AImported
Gene namesi
Name:MHC class I HLA-AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei305 – 329HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500416008422 – 362Sequence analysisAdd BLAST341

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiO78126

Structurei

3D structure databases

ProteinModelPortaliO78126
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 292Ig-likeInterPro annotationAdd BLAST87

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG016709

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

O78126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRTLVLLL SGALALTQTW AGSHSMRYFF TSVSRPGRGE PRFIAVGYVD
60 70 80 90 100
DTQFVRFDSD AASQRMEPRA PWIEQEGPEY WDGETRKVKA HSQTHRVDLG
110 120 130 140 150
TLRGYYNQSE AGSHTVQRMY GCDVGSDWRF LRGYHQYAYD GKDYIALKED
160 170 180 190 200
LRSWTAADMA AQTTKHKWEA AHVAEQLRAY LEGTCVEWLR RYLENGKETL
210 220 230 240 250
QRTDAPKTHM THHAVSDHEA TLRCWALSFY PAEITLTWQR DGEDQTQDTE
260 270 280 290 300
LVETRPAGDG TFQKWAAVVV PSGQEQRYTC HVQHEGLPKP LTLRWEPSSQ
310 320 330 340 350
PTIPIVGIIA GLVLFGAVIT GAVVAAVMWR RKSSDRKGGS YSQAASSDSA
360
QGSDVSLTAC KV
Length:362
Mass (Da):40,620
Last modified:November 1, 1998 - v1
Checksum:iC736072B75CD48A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055066 Genomic DNA Translation: AAC24825.1
RefSeqiXP_016885777.1, XM_017030288.1
UniGeneiHs.181244
Hs.713441

Genome annotation databases

GeneIDi3105

Similar proteinsi

Entry informationi

Entry nameiO78126_HUMAN
AccessioniPrimary (citable) accession number: O78126
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: February 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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