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Protein
Submitted name:

Chemokine receptor CCR5

Gene

CCR5

Organism
Cercocebus torquatus torquatus
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Chemokine receptor CCR5Imported
Gene namesi
Name:CCR5Imported
OrganismiCercocebus torquatus torquatusImported
Taxonomic identifieri81944 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeCercocebus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621HelicalSequence analysisAdd
BLAST
Transmembranei68 – 8720HelicalSequence analysisAdd
BLAST
Transmembranei107 – 12923HelicalSequence analysisAdd
BLAST
Transmembranei141 – 15919HelicalSequence analysisAdd
BLAST
Transmembranei190 – 21324HelicalSequence analysisAdd
BLAST
Transmembranei225 – 24319HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 289243G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG106917.

Family and domain databases

InterProiIPR002240. Chemokine_CCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O77833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYQVSSPTY DIDYYTSEPC QKINVKQIAA RLLPPLYSLV FVFGFVGNIL
60 70 80 90 100
VVLILINCKR LKSMTDIYLL NLAISDLLFL LTVPFWAHYA AAQWDFGNTM
110 120 130 140 150
CQLLTGLYFI GFFSGIFFII LLTIDRYLAI VHAVFALKAR TVTFGVVAVF
160 170 180 190 200
ASLPGIIFTR SQREGLHYTC SSHFPYSQYQ FWKNFQTLKI VILGLVLPLL
210 220 230 240 250
VMVICYSGIL KTLLRCRNEK KRHRAVRLIF TIMIVYFLFW APYNIVLLLN
260 270 280 290 300
TFQEFFGLNN CSSSNRLDQA MQVTETLGMT HCCINPIIYA FVGEKFRNYL
310 320 330 340
LVFFQKHIAK RFCKCCSIFQ QEASERASSV YTRSTGEQEI SVGL
Length:344
Mass (Da):39,579
Last modified:November 1, 1998 - v1
Checksum:i0CEC05E47C2F6DE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084002 Genomic DNA. Translation: AAC62470.1.
AF094752 Genomic DNA. Translation: AAC62473.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084002 Genomic DNA. Translation: AAC62470.1.
AF094752 Genomic DNA. Translation: AAC62473.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG106917.

Family and domain databases

InterProiIPR002240. Chemokine_CCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Natural infection of a homozygous delta24 CCR5 red-capped mangabey with an R2b-tropic simian immunodeficiency virus."
    Chen Z., Kwon D., Jin Z., Monard S., Telfer P., Jones M.S., Lu C.Y., Aguilar R.F., Ho D.D., Marx P.A.
    J. Exp. Med. 188:2057-2065(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO77833_CERTR
AccessioniPrimary (citable) accession number: O77833
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.