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Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation.By similarity

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei226SubstrateBy similarity1
Metal bindingi458Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processLipid metabolism, Steroid metabolism, Sterol metabolism
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1By similarity)
Alternative name(s):
CYPIA2
Cholesterol 25-hydroxylaseBy similarity
Gene namesi
Name:CYP1A2
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
Proteomesi
  • UP000008225 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002329071 – 516Cytochrome P450 1A2Add BLAST516

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69O-linked (GlcNAc) serineBy similarity1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000032736.

Structurei

3D structure databases

ProteinModelPortaliO77810.
SMRiO77810.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiO77810.
KOiK07409.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
IPR036396. Cyt_P450_sf.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

O77810-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSQFVPFS ATELLLTSTV FCLVFWVFKG LRPRVPKGLK SPPEPWRWPL
60 70 80 90 100
LGHVLTLGKN PHLALTKMSQ RYGDVLQIHI GSTPVVVLSG LDTIRQALVR
110 120 130 140 150
QGDDFKGRPD LYSFTLITDG QSMSFSPDSG PVWAARRRLA QNALNTFSIA
160 170 180 190 200
SDPASSSSCY LEEHVSKEAE ALIGRLQELM AGPGRFDPYN QIVESVVKVI
210 220 230 240 250
GAMCFGQHFP ESSDEMLSLM KNSHVFVENA TSGNPVDFFP ILRYLPNPAL
260 270 280 290 300
QRFKAFNQRF LRFLRETVQE HYQDSDKNSV QDITGALFKH CEKRSGASGD
310 320 330 340 350
LIPQEKIVNL VNDIFGAGFD TITTAISWSL MYLVTKPEIQ RKIQKELDTV
360 370 380 390 400
IGRGRRPRLS DRPQLPYLEA FILETFRHSS FVPFTIPHST TRDTTLKGFY
410 420 430 440 450
IPKECCVFIN QWQVNHDPQL WGDPSEFRPE RFLTAKGTAL NKPLSEKILL
460 470 480 490 500
FGLGKRRCIG EVLGKWEVFL FLAILLQQLE FSVPPGVQID LTPTYGLTMK
510
HARCEHVQAR LRFSFQ
Length:516
Mass (Da):58,407
Last modified:January 23, 2007 - v3
Checksum:iE2186060C285D938
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86475 mRNA. Translation: BAA33790.1.
RefSeqiNP_001191363.1. NM_001204434.1.

Genome annotation databases

GeneIDi100392712.
KEGGicjc:100392712.

Similar proteinsi

Entry informationi

Entry nameiCP1A2_CALJA
AccessioniPrimary (citable) accession number: O77810
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 98 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families