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O77810

- CP1A2_CALJA

UniProt

O77810 - CP1A2_CALJA

Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation By similarity.By similarity

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei226 – 2261SubstrateBy similarity
    Metal bindingi458 – 4581Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A2 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA2
    Gene namesi
    Name:CYP1A2
    OrganismiCallithrix jacchus (White-tufted-ear marmoset)
    Taxonomic identifieri9483 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
    ProteomesiUP000008225: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 516515Cytochrome P450 1A2PRO_0000232907Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi69 – 691O-linked (GlcNAc)By similarity

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliO77810.
    SMRiO77810. Positions 34-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000036991.
    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O77810-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALSQFVPFS ATELLLTSTV FCLVFWVFKG LRPRVPKGLK SPPEPWRWPL    50
    LGHVLTLGKN PHLALTKMSQ RYGDVLQIHI GSTPVVVLSG LDTIRQALVR 100
    QGDDFKGRPD LYSFTLITDG QSMSFSPDSG PVWAARRRLA QNALNTFSIA 150
    SDPASSSSCY LEEHVSKEAE ALIGRLQELM AGPGRFDPYN QIVESVVKVI 200
    GAMCFGQHFP ESSDEMLSLM KNSHVFVENA TSGNPVDFFP ILRYLPNPAL 250
    QRFKAFNQRF LRFLRETVQE HYQDSDKNSV QDITGALFKH CEKRSGASGD 300
    LIPQEKIVNL VNDIFGAGFD TITTAISWSL MYLVTKPEIQ RKIQKELDTV 350
    IGRGRRPRLS DRPQLPYLEA FILETFRHSS FVPFTIPHST TRDTTLKGFY 400
    IPKECCVFIN QWQVNHDPQL WGDPSEFRPE RFLTAKGTAL NKPLSEKILL 450
    FGLGKRRCIG EVLGKWEVFL FLAILLQQLE FSVPPGVQID LTPTYGLTMK 500
    HARCEHVQAR LRFSFQ 516
    Length:516
    Mass (Da):58,407
    Last modified:January 23, 2007 - v3
    Checksum:iE2186060C285D938
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86475 mRNA. Translation: BAA33790.1.
    RefSeqiNP_001191363.1. NM_001204434.1.

    Genome annotation databases

    GeneIDi100392712.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86475 mRNA. Translation: BAA33790.1 .
    RefSeqi NP_001191363.1. NM_001204434.1.

    3D structure databases

    ProteinModelPortali O77810.
    SMRi O77810. Positions 34-514.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100392712.

    Organism-specific databases

    CTDi 1544.

    Phylogenomic databases

    HOGENOMi HOG000036991.
    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Marmoset CYP1A2: primary structure and constitutive expression in livers."
      Sakuma T., Igarashi T., Hieda M., Ohgiya S., Isogai M., Ninomiya S., Nagata R., Nemoto N., Kamataki T.
      Carcinogenesis 18:1985-1991(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A2_CALJA
    AccessioniPrimary (citable) accession number: O77810
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 82 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3