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Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation (By similarity).By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei226 – 2261SubstrateBy similarity
Metal bindingi458 – 4581Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1)
Alternative name(s):
CYPIA2
Gene namesi
Name:CYP1A2
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
ProteomesiUP000008225: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 516515Cytochrome P450 1A2PRO_0000232907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691O-linked (GlcNAc)By similarity

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliO77810.
SMRiO77810. Positions 34-514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiO77810.
KOiK07409.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77810-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALSQFVPFS ATELLLTSTV FCLVFWVFKG LRPRVPKGLK SPPEPWRWPL
60 70 80 90 100
LGHVLTLGKN PHLALTKMSQ RYGDVLQIHI GSTPVVVLSG LDTIRQALVR
110 120 130 140 150
QGDDFKGRPD LYSFTLITDG QSMSFSPDSG PVWAARRRLA QNALNTFSIA
160 170 180 190 200
SDPASSSSCY LEEHVSKEAE ALIGRLQELM AGPGRFDPYN QIVESVVKVI
210 220 230 240 250
GAMCFGQHFP ESSDEMLSLM KNSHVFVENA TSGNPVDFFP ILRYLPNPAL
260 270 280 290 300
QRFKAFNQRF LRFLRETVQE HYQDSDKNSV QDITGALFKH CEKRSGASGD
310 320 330 340 350
LIPQEKIVNL VNDIFGAGFD TITTAISWSL MYLVTKPEIQ RKIQKELDTV
360 370 380 390 400
IGRGRRPRLS DRPQLPYLEA FILETFRHSS FVPFTIPHST TRDTTLKGFY
410 420 430 440 450
IPKECCVFIN QWQVNHDPQL WGDPSEFRPE RFLTAKGTAL NKPLSEKILL
460 470 480 490 500
FGLGKRRCIG EVLGKWEVFL FLAILLQQLE FSVPPGVQID LTPTYGLTMK
510
HARCEHVQAR LRFSFQ
Length:516
Mass (Da):58,407
Last modified:January 23, 2007 - v3
Checksum:iE2186060C285D938
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86475 mRNA. Translation: BAA33790.1.
RefSeqiNP_001191363.1. NM_001204434.1.

Genome annotation databases

GeneIDi100392712.
KEGGicjc:100392712.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86475 mRNA. Translation: BAA33790.1.
RefSeqiNP_001191363.1. NM_001204434.1.

3D structure databases

ProteinModelPortaliO77810.
SMRiO77810. Positions 34-514.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100392712.
KEGGicjc:100392712.

Organism-specific databases

CTDi1544.

Phylogenomic databases

HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiO77810.
KOiK07409.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Marmoset CYP1A2: primary structure and constitutive expression in livers."
    Sakuma T., Igarashi T., Hieda M., Ohgiya S., Isogai M., Ninomiya S., Nagata R., Nemoto N., Kamataki T.
    Carcinogenesis 18:1985-1991(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP1A2_CALJA
AccessioniPrimary (citable) accession number: O77810
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.