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Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.By similarity

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei226SubstrateBy similarity1
Metal bindingi458Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processLipid metabolism, Steroid metabolism, Sterol metabolism
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1By similarity)
Alternative name(s):
CYPIA2
Cholesterol 25-hydroxylaseBy similarity
Gene namesi
Name:CYP1A2
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516521 – 516Cytochrome P450 1A2Add BLAST516

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69O-linked (GlcNAc) serineBy similarity1

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Liver.

Inductioni

By 3-methylcholanthrene (3MC).1 Publication

Structurei

3D structure databases

ProteinModelPortaliO77809.
SMRiO77809.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944.
KOiK07409.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

O77809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSQSVPFL ATELLLASAI FCLVFWVLRG SRPRVPKGLK SPPEPWGWPL
60 70 80 90 100
LGHVLTLGKN PHLALSRMSQ LYGDVLQIRI GSTPVLVLSG LDTIRQALVR
110 120 130 140 150
QGDDFKGRPD LYSFTFITDG QSMSFSPDSG PVWAARRRLA QNALNTFSIA
160 170 180 190 200
SDPASSSSCY LEEHVSKEAE ALISRLQELM AGPGHFDPYN QVVVSVANVI
210 220 230 240 250
GAMCFGQHFP ESSDEMLSLV KNSHEFVESA SSGNPVDFFP ILRYLPNPAL
260 270 280 290 300
QRFKAFNQRF RRFLQKTVQE HYQDFDKNSV QDITGALFKH SKKGPRASGN
310 320 330 340 350
LIPQEKIVNL VNDIFGAGFD TIATAISWSL MYLVTKPEIQ RKIQKELDAV
360 370 380 390 400
IGRGRRPRLS DRPQLPYLEA FILETFRHSS FVPFTIPHST TRDTTLNGFY
410 420 430 440 450
IPRECCVFIN QWQVNHDPQL WGDPSEFRPE RFLTAEGTTI NKPLSEKIML
460 470 480 490 500
FGLGKRRCIG EVLGKWEVFL FLAILLQQLE FSVPPGVKVD LTPIYGLTMK
510
HARCEHFQAR LRFSIK
Length:516
Mass (Da):58,197
Last modified:January 23, 2007 - v3
Checksum:i3F71E3999EC4CDF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86474 mRNA. Translation: BAA33789.1.
RefSeqiNP_001306412.1. NM_001319483.1.
UniGeneiMfa.5411.

Genome annotation databases

GeneIDi102130662.
KEGGimcf:102130662.

Similar proteinsi

Entry informationi

Entry nameiCP1A2_MACFA
AccessioniPrimary (citable) accession number: O77809
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 89 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families