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O77809 (CP1A2_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A2

EC=1.14.14.1
Alternative name(s):
CYPIA2
Gene names
Name:CYP1A2
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length516 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Liver.

Induction

By 3-methylcholanthrene (3MC). Ref.1

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 516515Cytochrome P450 1A2
PRO_0000051652

Sites

Metal binding4581Iron (heme axial ligand) By similarity
Binding site2261Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
O77809 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 3F71E3999EC4CDF7

FASTA51658,197
        10         20         30         40         50         60 
MALSQSVPFL ATELLLASAI FCLVFWVLRG SRPRVPKGLK SPPEPWGWPL LGHVLTLGKN 

        70         80         90        100        110        120 
PHLALSRMSQ LYGDVLQIRI GSTPVLVLSG LDTIRQALVR QGDDFKGRPD LYSFTFITDG 

       130        140        150        160        170        180 
QSMSFSPDSG PVWAARRRLA QNALNTFSIA SDPASSSSCY LEEHVSKEAE ALISRLQELM 

       190        200        210        220        230        240 
AGPGHFDPYN QVVVSVANVI GAMCFGQHFP ESSDEMLSLV KNSHEFVESA SSGNPVDFFP 

       250        260        270        280        290        300 
ILRYLPNPAL QRFKAFNQRF RRFLQKTVQE HYQDFDKNSV QDITGALFKH SKKGPRASGN 

       310        320        330        340        350        360 
LIPQEKIVNL VNDIFGAGFD TIATAISWSL MYLVTKPEIQ RKIQKELDAV IGRGRRPRLS 

       370        380        390        400        410        420 
DRPQLPYLEA FILETFRHSS FVPFTIPHST TRDTTLNGFY IPRECCVFIN QWQVNHDPQL 

       430        440        450        460        470        480 
WGDPSEFRPE RFLTAEGTTI NKPLSEKIML FGLGKRRCIG EVLGKWEVFL FLAILLQQLE 

       490        500        510 
FSVPPGVKVD LTPIYGLTMK HARCEHFQAR LRFSIK 

« Hide

References

[1]"Molecular cloning and functional analysis of cynomolgus monkey CYP1A2."
Sakuma T., Hieda M., Igarashi T., Ohgiya S., Nagata R., Nemoto N., Kamataki T.
Biochem. Pharmacol. 56:131-139(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, CHARACTERIZATION.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D86474 mRNA. Translation: BAA33789.1.

3D structure databases

ProteinModelPortalO77809.
SMRO77809. Positions 34-514.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG106944.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP1A2_MACFA
AccessionPrimary (citable) accession number: O77809
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 23, 2007
Last modified: December 11, 2013
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families