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Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.By similarity

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei226SubstrateBy similarity1
Metal bindingi458Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Lipid metabolism, Steroid metabolism, Sterol metabolism

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1By similarity)
Alternative name(s):
CYPIA2
Cholesterol 25-hydroxylaseBy similarity
Gene namesi
Name:CYP1A2
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000516522 – 516Cytochrome P450 1A2Add BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69O-linked (GlcNAc)By similarity1

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Liver.

Inductioni

By 3-methylcholanthrene (3MC).1 Publication

Structurei

3D structure databases

ProteinModelPortaliO77809.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944.
KOiK07409.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSQSVPFL ATELLLASAI FCLVFWVLRG SRPRVPKGLK SPPEPWGWPL
60 70 80 90 100
LGHVLTLGKN PHLALSRMSQ LYGDVLQIRI GSTPVLVLSG LDTIRQALVR
110 120 130 140 150
QGDDFKGRPD LYSFTFITDG QSMSFSPDSG PVWAARRRLA QNALNTFSIA
160 170 180 190 200
SDPASSSSCY LEEHVSKEAE ALISRLQELM AGPGHFDPYN QVVVSVANVI
210 220 230 240 250
GAMCFGQHFP ESSDEMLSLV KNSHEFVESA SSGNPVDFFP ILRYLPNPAL
260 270 280 290 300
QRFKAFNQRF RRFLQKTVQE HYQDFDKNSV QDITGALFKH SKKGPRASGN
310 320 330 340 350
LIPQEKIVNL VNDIFGAGFD TIATAISWSL MYLVTKPEIQ RKIQKELDAV
360 370 380 390 400
IGRGRRPRLS DRPQLPYLEA FILETFRHSS FVPFTIPHST TRDTTLNGFY
410 420 430 440 450
IPRECCVFIN QWQVNHDPQL WGDPSEFRPE RFLTAEGTTI NKPLSEKIML
460 470 480 490 500
FGLGKRRCIG EVLGKWEVFL FLAILLQQLE FSVPPGVKVD LTPIYGLTMK
510
HARCEHFQAR LRFSIK
Length:516
Mass (Da):58,197
Last modified:January 23, 2007 - v3
Checksum:i3F71E3999EC4CDF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86474 mRNA. Translation: BAA33789.1.
RefSeqiNP_001306412.1. NM_001319483.1.
UniGeneiMfa.5411.

Genome annotation databases

GeneIDi102130662.
KEGGimcf:102130662.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86474 mRNA. Translation: BAA33789.1.
RefSeqiNP_001306412.1. NM_001319483.1.
UniGeneiMfa.5411.

3D structure databases

ProteinModelPortaliO77809.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102130662.
KEGGimcf:102130662.

Phylogenomic databases

HOVERGENiHBG106944.
KOiK07409.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP1A2_MACFA
AccessioniPrimary (citable) accession number: O77809
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 23, 2007
Last modified: October 5, 2016
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.