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Protein

Vasopressin V2 receptor

Gene

AVPR2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-CFA-388479. Vasopressin-like receptors.
R-CFA-418555. G alpha (s) signalling events.
R-CFA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-CFA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-CFA-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V2 receptor
Short name:
V2R
Alternative name(s):
AVPR V2
Antidiuretic hormone receptor
Renal-type arginine vasopressin receptor
Gene namesi
Name:AVPR2
Synonyms:V2R
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome X

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularSequence analysisAdd BLAST37
Transmembranei38 – 62Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini63 – 76CytoplasmicSequence analysisAdd BLAST14
Transmembranei77 – 97Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini98 – 112ExtracellularSequence analysisAdd BLAST15
Transmembranei113 – 134Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini135 – 158CytoplasmicSequence analysisAdd BLAST24
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 199ExtracellularSequence analysisAdd BLAST20
Transmembranei200 – 219Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini220 – 270CytoplasmicSequence analysisAdd BLAST51
Transmembranei271 – 292Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini293 – 307ExtracellularSequence analysisAdd BLAST15
Transmembranei308 – 327Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini328 – 370CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702071 – 370Vasopressin V2 receptorAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...)Sequence analysis1
Lipidationi340S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO77808.

Interactioni

Subunit structurei

Interacts with ARRDC4. Identified in a complex containing at least ARRDC4, V2R and HGS.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000028678.

Structurei

3D structure databases

ProteinModelPortaliO77808.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiO77808.
KOiK04228.
OMAiGGARWNR.
OrthoDBiEOG091G0DB6.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O77808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLASTTSAV PRTLSPPTPA GNGSRELLDT RDPLLVQAEL ALLSTVFVAV
60 70 80 90 100
ALSNGLVLGA LARRVRRGRW APMHVFIGHL CLADLAVALF QVLPQLAWDA
110 120 130 140 150
TDRFRGPDAL CRAVKYLQMV GMYASSYMIL AMTLDRHRAI CRPMLAYRHG
160 170 180 190 200
GGARWNRPVL VAWAFSLILS LPQLFIFAQR DVGNGSGVLD CWAHFAEPWG
210 220 230 240 250
LRAYVTWIAL MVFVAPALGI AACQVLIFRE IHSSLVPGPA ERAGGCRGGH
260 270 280 290 300
RTGSPSEGAR VSAAMAKTVR MTLVIVIVYV LCWAPFFLVQ LWAAWDPQAP
310 320 330 340 350
LEGAPFVLLM LLASLNSCTN PWIYAFFSSS VSSELRSLFC WARSRAPPSL
360 370
GPQEESCATA SSFLAKDTSS
Length:370
Mass (Da):40,200
Last modified:November 1, 1998 - v1
Checksum:i8F4E133FAF800B5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18136 mRNA. Translation: CAA77063.1.
AJ238150 Genomic DNA. Translation: CAB41598.1.
RefSeqiNP_001003177.1. NM_001003177.1.
XP_005641040.1. XM_005640983.2.
UniGeneiCfa.3666.

Genome annotation databases

EnsembliENSCAFT00000030844; ENSCAFP00000028678; ENSCAFG00000019402.
GeneIDi403804.
KEGGicfa:403804.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18136 mRNA. Translation: CAA77063.1.
AJ238150 Genomic DNA. Translation: CAB41598.1.
RefSeqiNP_001003177.1. NM_001003177.1.
XP_005641040.1. XM_005640983.2.
UniGeneiCfa.3666.

3D structure databases

ProteinModelPortaliO77808.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000028678.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO77808.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000030844; ENSCAFP00000028678; ENSCAFG00000019402.
GeneIDi403804.
KEGGicfa:403804.

Organism-specific databases

CTDi554.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiO77808.
KOiK04228.
OMAiGGARWNR.
OrthoDBiEOG091G0DB6.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiR-CFA-388479. Vasopressin-like receptors.
R-CFA-418555. G alpha (s) signalling events.
R-CFA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-CFA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-CFA-8856828. Clathrin-mediated endocytosis.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV2R_CANLF
AccessioniPrimary (citable) accession number: O77808
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.