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Protein

Angiopoietin-2

Gene

ANGPT2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi429CalciumBy similarity1
Metal bindingi431CalciumBy similarity1
Metal bindingi433Calcium; via carbonyl oxygenBy similarity1
Metal bindingi435Calcium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Differentiation
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-210993 Tie2 Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-2
Short name:
ANG-2
Gene namesi
Name:ANGPT2
Synonyms:ANG2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 27

Organism-specific databases

VGNCiVGNC:25888 ANGPT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000009906319 – 496Angiopoietin-2Add BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi284 ↔ 313PROSITE-ProRule annotation
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi433 ↔ 435PROSITE-ProRule annotation
Disulfide bondi437 ↔ 450PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO77802
PRIDEiO77802

Expressioni

Developmental stagei

Found to be expressed throughout the ovarian cycle. Overexpressed during luteolysis, this could reflect the regression of capillaries that had developed pericyte contact in the midstage corpus luteum.

Gene expression databases

BgeeiENSBTAG00000011034
ExpressionAtlasiO77802 baseline and differential

Interactioni

Subunit structurei

Interacts with TEK/TIE2, competing for the same binding site as ANGPT1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014656

Structurei

3D structure databases

ProteinModelPortaliO77802
SMRiO77802
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini275 – 495Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST221

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili167 – 249Sequence analysisAdd BLAST83

Domaini

The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.By similarity

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00760000118809
HOGENOMiHOG000037128
HOVERGENiHBG001644
InParanoidiO77802
KOiK05466
OMAiYWKGSGY
OrthoDBiEOG091G03M1
TreeFamiTF336658

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 2 hits
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR028844 Ang-2
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PANTHERiPTHR19143:SF199 PTHR19143:SF199, 1 hit
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77802-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWQLVFLTLS CDLAVATAHS GSRKGMDIAA GKKQYQVQHG ACSYTFLLPE
60 70 80 90 100
TDHCRSPSSA YVPNAVQRDA PLDYDDSVQR LQVLENIMEN NTQWLMKLEN
110 120 130 140 150
YIQDNMKKEM VEIQQNAVQN QTAVMIEIGT NLLNQTAEQT RKLTDVEAQV
160 170 180 190 200
LNQTTRLELQ LLEHSLSTNK LEKQILDQTS EISKLQDKNS FLEKKVLDME
210 220 230 240 250
DKHIVQLRSI KEEKDQLQVL VSKQNSIIEE LEKQLVTATV NNSVLQKQQH
260 270 280 290 300
DLMETVNNLL TLMSTSNPSY SLLAKDEQII FRDCGEAFKS GLTTSGVYTL
310 320 330 340 350
TFPNSTEEIK AYCDMETGGG GWTVIQRRED GSVDFQRTWK EYKVGFGNPS
360 370 380 390 400
GEHWLGNEFV SQVTGQKRYV LKIHLRDWEG NEAYSLYDHF YLSNEELNYR
410 420 430 440 450
IHLKGLTGTA GKISSISQPG NDFSTKDADN DKCICKCSQM LTGGWWFDAC
460 470 480 490
GPSNLNGMYY PQRQNTNKFN GIKWYYWKGS GYSLKATTMM IRPADF
Length:496
Mass (Da):56,539
Last modified:November 13, 2007 - v3
Checksum:i3DC10D0246E89E95
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti393S → L in AAC78285 (PubMed:9776732).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142471 mRNA Translation: AAI42472.1
AF094699 mRNA Translation: AAC62490.1
AF032924 mRNA Translation: AAC78285.1
RefSeqiNP_001092325.1, NM_001098855.1
UniGeneiBt.137

Genome annotation databases

EnsembliENSBTAT00000014656; ENSBTAP00000014656; ENSBTAG00000011034
GeneIDi282141
KEGGibta:282141

Similar proteinsi

Entry informationi

Entry nameiANGP2_BOVIN
AccessioniPrimary (citable) accession number: O77802
Secondary accession number(s): A5PKF7, Q9TSK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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