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Protein

Mitochondrial uncoupling protein 3

Gene

UCP3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 3
Short name:
UCP 3
Alternative name(s):
Solute carrier family 25 member 9
Gene namesi
Name:UCP3
Synonyms:SLC25A9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3222Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei77 – 9923Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei120 – 13617Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei183 – 19917Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei217 – 23620Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei271 – 29323Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Mitochondrial uncoupling protein 3PRO_0000090670Add
BLAST

Proteomic databases

PaxDbiO77792.
PRIDEiO77792.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006918.

Structurei

3D structure databases

ProteinModelPortaliO77792.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 10595Solcar 1Add
BLAST
Repeati114 – 20592Solcar 2Add
BLAST
Repeati214 – 29986Solcar 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni278 – 30023Purine nucleotide bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiO77792.
KOiK15103.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O77792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGLQPSERP PTTSVKFLAA GTAACFADLL TFPLDTAKVR LQIQGENQAA
60 70 80 90 100
LAARSAQYRG VLGTILTMVR TEGPRSLYSG LVAGLQRQMS FASIRIGLYD
110 120 130 140 150
SVKQFYTPKG SDHSSIITRI LAGCTTGAMA VTCAQPTDVV KIRFQASMHT
160 170 180 190 200
GLGGNRKYSG TMDAYRTIAR EEGVRGLWKG ILPNITRNAI VNCGEMVTYD
210 220 230 240 250
IIKEKLLDYH LLTDNFPCHF VSAFGAGFCA TLVASPVDVV KTRYMNSPPG
260 270 280 290 300
QYHSPFDCML KMVTQEGPTA FYKGFTPSFL RLGSWNVVMF VTYEQMKRAL
310
MKVQMLRDSP F
Length:311
Mass (Da):34,206
Last modified:November 1, 1998 - v1
Checksum:iB1A1D26E25650D04
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531A → T.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092048 mRNA. Translation: AAC61762.1.
AF127030 Genomic DNA. Translation: AAD33339.1.
RefSeqiNP_776635.1. NM_174210.1.
UniGeneiBt.136.

Genome annotation databases

GeneIDi281563.
KEGGibta:281563.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092048 mRNA. Translation: AAC61762.1.
AF127030 Genomic DNA. Translation: AAD33339.1.
RefSeqiNP_776635.1. NM_174210.1.
UniGeneiBt.136.

3D structure databases

ProteinModelPortaliO77792.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006918.

Proteomic databases

PaxDbiO77792.
PRIDEiO77792.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281563.
KEGGibta:281563.

Organism-specific databases

CTDi7352.

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiO77792.
KOiK15103.

Miscellaneous databases

NextBioi20805513.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-274, VARIANT THR-53.
    Tissue: Muscle.

Entry informationi

Entry nameiUCP3_BOVIN
AccessioniPrimary (citable) accession number: O77792
Secondary accession number(s): Q9TVA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: February 17, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.