Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Short-chain dehydrogenase/reductase 3

Gene

DHRS3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.By similarity

Catalytic activityi

All-trans-retinol + NADP+ = all-trans-retinal + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei175 – 1751SubstrateBy similarity
Active sitei188 – 1881Proton acceptorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Short-chain dehydrogenase/reductase 3 (EC:1.1.1.300)
Alternative name(s):
Retinal short-chain dehydrogenase/reductase 1
Short name:
retSDR1
Gene namesi
Name:DHRS3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence analysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence analysisAdd
BLAST
Transmembranei195 – 21521HelicalSequence analysisAdd
BLAST
Transmembranei253 – 27321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Short-chain dehydrogenase/reductase 3PRO_0000054643Add
BLAST

Proteomic databases

PaxDbiO77769.
PRIDEiO77769.

Expressioni

Tissue specificityi

In the retina, expressed in cone but not rod outer segments.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000033930.

Structurei

3D structure databases

ProteinModelPortaliO77769.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1201. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG051352.
InParanoidiO77769.
KOiK11146.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR032969. DHRS3.
IPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PTHR24322:SF483. PTHR24322:SF483. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

O77769-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWKRLGALV VFPLQMIYLV VKAAVGLVLP AKLRDLSREN VLITGGGRGI
60 70 80 90 100
GRQLAREFAE RGARKIVLWG RTEKCLKETT EEIRQMGTEC HYFICDVGNR
110 120 130 140 150
EEVYQTAKAV REKVGDITIL VNNAAVVHGK SLMDSDDDAL PKSQHINTLG
160 170 180 190 200
QFWTTKAFLP RMLELQNGHI VCLNSVLALS AIPGAIDYCT SKASAFAFME
210 220 230 240 250
SLTLGLLDCP GVSATTVLPF HTSTEMFQGM RVRFPNLFPP LKPETVARRT
260 270 280 290 300
VEAVQLNQAL LLLPWTMHAL IILKSILPQA ALEEIHKFSG TYTCINTFKG

RT
Length:302
Mass (Da):33,496
Last modified:November 1, 1998 - v1
Checksum:i855FD2488ACB243E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561R → L in AAI04576 (Ref. 2) Curated
Sequence conflicti141 – 1411P → L in AAI04576 (Ref. 2) Curated
Sequence conflicti295 – 2951I → M in AAI04576 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061742 mRNA. Translation: AAC63264.1.
BC104575 mRNA. Translation: AAI04576.1.
RefSeqiNP_776605.2. NM_174180.3.
UniGeneiBt.5530.

Genome annotation databases

GeneIDi281482.
KEGGibta:281482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061742 mRNA. Translation: AAC63264.1.
BC104575 mRNA. Translation: AAI04576.1.
RefSeqiNP_776605.2. NM_174180.3.
UniGeneiBt.5530.

3D structure databases

ProteinModelPortaliO77769.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000033930.

Proteomic databases

PaxDbiO77769.
PRIDEiO77769.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281482.
KEGGibta:281482.

Organism-specific databases

CTDi9249.

Phylogenomic databases

eggNOGiKOG1201. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG051352.
InParanoidiO77769.
KOiK11146.

Miscellaneous databases

NextBioi20805457.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR032969. DHRS3.
IPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PTHR24322:SF483. PTHR24322:SF483. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal."
    Haeseleer F., Huang J., Lebioda L., Saari J.C., Palczewski K.
    J. Biol. Chem. 273:21790-21799(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Retina.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon.

Entry informationi

Entry nameiDHRS3_BOVIN
AccessioniPrimary (citable) accession number: O77769
Secondary accession number(s): Q3MHX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.