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Protein

Interleukin-4

Gene

IL4

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processB-cell activation

Enzyme and pathway databases

ReactomeiR-CFA-6785807. Interleukin-4 and 13 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-4
Short name:
IL-4
Alternative name(s):
B-cell stimulatory factor 1
Short name:
BSF-1
Lymphocyte stimulatory factor 1
Gene namesi
Name:IL4
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000001552625 – 132Interleukin-4Add BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi48 ↔ 84By similarity
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi70 ↔ 104By similarity
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO77762.

Expressioni

Gene expression databases

BgeeiENSCAFG00000000880.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000001253.

Structurei

3D structure databases

ProteinModelPortaliO77762.
SMRiO77762.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3886. Eukaryota.
ENOG410XQ0R. LUCA.
GeneTreeiENSGT00390000013108.
HOGENOMiHOG000254781.
HOVERGENiHBG000290.
InParanoidiO77762.
KOiK05430.
OMAiLACTSNF.
OrthoDBiEOG091G0WDE.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR002354. IL-4.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
PfamiView protein in Pfam
PF00727. IL4. 1 hit.
PIRSFiPIRSF001941. Interleukin_4. 1 hit.
PRINTSiPR00431. INTERLEUKIN4.
SMARTiView protein in SMART
SM00190. IL4_13. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00838. INTERLEUKIN_4_13. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTSQLIPT LVCLLALTST FVHGHNFNIT IKEIIKMLNI LTARNDSCME
60 70 80 90 100
LTVKDVFTAP KNTSDKEIFC RAATVLRQIY THNCSNRYLR GLYRNLSSMA
110 120 130
NKTCSMNEIK KSTLKDFLER LKVIMQKKYY RH
Length:132
Mass (Da):15,267
Last modified:November 1, 1998 - v1
Checksum:i6F75D8FBB6818945
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054833 mRNA. Translation: AAD11563.1.
AF083270 mRNA. Translation: AAD09005.1.
AF104245 mRNA. Translation: AAC83931.1.
AF187322 mRNA. Translation: AAF01043.1.
AF239917 mRNA. Translation: AAF60177.1.
EF095771 mRNA. Translation: ABL01502.1.
RefSeqiNP_001003159.1. NM_001003159.1.
UniGeneiCfa.39.

Genome annotation databases

EnsembliENSCAFT00000001367; ENSCAFP00000001253; ENSCAFG00000000880.
GeneIDi403785.
KEGGicfa:403785.

Similar proteinsi

Entry informationi

Entry nameiIL4_CANLF
AccessioniPrimary (citable) accession number: O77762
Secondary accession number(s): A1E293
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: October 25, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families