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Protein

Inhibin alpha chain

Gene

INHA

Organism
Trichosurus vulpecula (Brush-tailed possum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin alpha chain
Gene namesi
Name:INHA
OrganismiTrichosurus vulpecula (Brush-tailed possum)
Taxonomic identifieri9337 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDiprotodontiaPhalangeridaeTrichosurus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
PropeptideiPRO_000003369922 – 64By similarityAdd BLAST43
PropeptideiPRO_000003370065 – 230Inhibin alpha N-terminal regionBy similarityAdd BLAST166
ChainiPRO_0000033701231 – 361Inhibin alpha chainAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi260 ↔ 323By similarity
Glycosylationi266N-linked (GlcNAc...)By similarity1
Disulfide bondi289 ↔ 358By similarity
Disulfide bondi293 ↔ 360By similarity
Disulfide bondi322InterchainBy similarity

Post-translational modificationi

Proteolytic processing yields a number of bioactive forms, consisting either solely of the mature alpha chain, of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, or of the entire proprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei64 – 65CleavageBy similarity2
Sitei230 – 231CleavageBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.

Structurei

3D structure databases

ProteinModelPortaliO77755.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG052131.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR017175. Inhibin_asu_subgr.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037328. Inhibin_alpha_subunit. 1 hit.
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLLLPLQL LLLMVMKGGH GCQGPELDRE LVLAKVRALV LDALGPPNAS
60 70 80 90 100
KDGGKPVAQR LTRRHAHTGG STRRSMENED EDLSQVILFP TTGPGCEDEP
110 120 130 140 150
EARAAEGLFT YTFRPSLHTR SRQVTAAQLW FHTGLDKVGA EVHNDSGPMV
160 170 180 190 200
TLLAMSSGGP MAVPILLGPA PPHWAVLHLA APAFTLLTRP LLVLLLRCPN
210 220 230 240 250
CPCPAQLDAT PFLVAHTRAR PPSVGERARR SPLPPPWPWS PAALRLLQRP
260 270 280 290 300
SEDPAAHADC HRAALNISFQ ELGWDQWIVH PPSFIFHYCH GGCGLVPSPV
310 320 330 340 350
LSPGAALTPS QPLPLGPGSR PCCAAMPSTM RPLRVRTTSD GGYSFKYEIV
360
PNLLTQHCAC I
Length:361
Mass (Da):38,945
Last modified:November 1, 1998 - v1
Checksum:iD661CDF93CDAA87D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033340 mRNA. Translation: AAC63945.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033340 mRNA. Translation: AAC63945.1.

3D structure databases

ProteinModelPortaliO77755.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG052131.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR017175. Inhibin_asu_subgr.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037328. Inhibin_alpha_subunit. 1 hit.
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINHA_TRIVU
AccessioniPrimary (citable) accession number: O77755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: January 7, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.