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Protein

Osteomodulin

Gene

OMD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Osteomodulin
Alternative name(s):
Keratan sulfate proteoglycan osteomodulin
Short name:
KSPG osteomodulin
Osteoadherin
Short name:
OSAD
Gene namesi
Name:OMD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000003275221 – 27Sequence analysis7
ChainiPRO_000003275328 – 422OsteomodulinAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22SulfotyrosineBy similarity1
Modified residuei25SulfotyrosineBy similarity1
Modified residuei31SulfotyrosineBy similarity1
Modified residuei39SulfotyrosineBy similarity1
Modified residuei51SulfotyrosineBy similarity1
Modified residuei77SulfotyrosineBy similarity1
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Glycosylationi242N-linked (GlcNAc...)Sequence analysis1
Glycosylationi278N-linked (GlcNAc...)Sequence analysis1
Glycosylationi316N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi321 ↔ 353By similarity
Modified residuei412SulfotyrosineBy similarity1
Modified residuei413SulfotyrosineBy similarity1

Post-translational modificationi

The N-terminus is blocked.
Some of the oligosaccharides are extended to keratan sulfate chains.
Sulfated on tyrosine residue(s).Curated

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan, Sulfation

Proteomic databases

PaxDbiO77742.
PRIDEiO77742.

Expressioni

Tissue specificityi

Bone specific.

Interactioni

Subunit structurei

Binds the alpha(V)beta(3)-integrin.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015704.

Structurei

3D structure databases

ProteinModelPortaliO77742.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 91LRRNTAdd BLAST39
Repeati92 – 113LRR 1Add BLAST22
Repeati116 – 129LRR 2Add BLAST14
Repeati142 – 164LRR 3Add BLAST23
Repeati165 – 184LRR 4Add BLAST20
Repeati187 – 207LRR 5Add BLAST21
Repeati213 – 233LRR 6Add BLAST21
Repeati234 – 255LRR 7Add BLAST22
Repeati258 – 280LRR 8Add BLAST23
Repeati281 – 294LRR 9Add BLAST14
Repeati301 – 322LRR 10Add BLAST22
Repeati331 – 353LRR 11Add BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 78Cys-richAdd BLAST17
Compositional biasi385 – 406Asp/Glu-rich (acidic)Add BLAST22

Sequence similaritiesi

Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiO77742.
KOiK08124.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR030705. Osteomodulin.
[Graphical view]
PANTHERiPTHR24373:SF155. PTHR24373:SF155. 1 hit.
PfamiPF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77742-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFSSLVCVL FFFLGVKVYC QYESYQWDED YDQEPDDVYQ TEFQFQQNIN
60 70 80 90 100
YEAPFHQHTL GCASECFCPP NFPSSMYCDN RKLKTIPNIP AHIQQVYLQF
110 120 130 140 150
NEIEAVTADS FINATHLKEI NLSHNKIKSQ KIDHGVFATL PNLLQLHLQH
160 170 180 190 200
NNLEDFPFPL PKSLERIFLG YNEISRLQTN AVNGLVNLTM LDLCFNKIDD
210 220 230 240 250
SVLQEKVLAK MEKLMQLNLC NNRLESMPPG LPSSLMYLSL ENNSISSIPE
260 270 280 290 300
NYFNKLPKLH ALRISHNKLQ DIPYNIFNLS NLIELNVGHN KLKQAFYIPR
310 320 330 340 350
NLEHLYLENN EIENVNVTVM CPSVDPLHYH HLTHIRIDQN KLKAPISSYI
360 370 380 390 400
FLCFPHIHTI YYGEQQSTNG QTIQLKTQVF RRFQDDGDSE DHDDHHEGPE
410 420
EEGTEENIDA HYYGSQEWQE TI
Length:422
Mass (Da):49,116
Last modified:November 1, 1998 - v1
Checksum:i3C349C3D6B59F5AD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191L → R AA sequence (PubMed:9566981).Curated1
Sequence conflicti194C → Y AA sequence (PubMed:9566981).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67279 mRNA. Translation: AAC39259.1.
RefSeqiNP_776372.1. NM_173947.2.
UniGeneiBt.114.

Genome annotation databases

GeneIDi280885.
KEGGibta:280885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67279 mRNA. Translation: AAC39259.1.
RefSeqiNP_776372.1. NM_173947.2.
UniGeneiBt.114.

3D structure databases

ProteinModelPortaliO77742.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015704.

Proteomic databases

PaxDbiO77742.
PRIDEiO77742.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280885.
KEGGibta:280885.

Organism-specific databases

CTDi4958.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiO77742.
KOiK08124.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR030705. Osteomodulin.
[Graphical view]
PANTHERiPTHR24373:SF155. PTHR24373:SF155. 1 hit.
PfamiPF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOMD_BOVIN
AccessioniPrimary (citable) accession number: O77742
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.