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O77742 (OMD_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Osteomodulin
Alternative name(s):
Keratan sulfate proteoglycan osteomodulin
Short name=KSPG osteomodulin
Osteoadherin
Short name=OSAD
Gene names
Name:OMD
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin.

Subunit structure

Binds the alpha(V)beta(3)-integrin.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Tissue specificity

Bone specific.

Post-translational modification

The N-terminus is blocked.

Some of the oligosaccharides are extended to keratan sulfate chains.

Sulfated on tyrosine residue(s) Probable.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.

Contains 11 LRR (leucine-rich) repeats.

Contains 1 LRRNT domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Propeptide21 – 277 Potential
PRO_0000032752
Chain28 – 422395Osteomodulin
PRO_0000032753

Regions

Domain53 – 9139LRRNT
Repeat92 – 11322LRR 1
Repeat116 – 12914LRR 2
Repeat142 – 16423LRR 3
Repeat165 – 18420LRR 4
Repeat187 – 20721LRR 5
Repeat213 – 23321LRR 6
Repeat234 – 25522LRR 7
Repeat258 – 28023LRR 8
Repeat281 – 29414LRR 9
Repeat301 – 32222LRR 10
Repeat331 – 35323LRR 11
Compositional bias62 – 7817Cys-rich
Compositional bias385 – 40622Asp/Glu-rich (acidic)

Amino acid modifications

Modified residue221Sulfotyrosine By similarity
Modified residue251Sulfotyrosine By similarity
Modified residue311Sulfotyrosine By similarity
Modified residue391Sulfotyrosine By similarity
Modified residue511Sulfotyrosine By similarity
Modified residue771Sulfotyrosine By similarity
Modified residue4121Sulfotyrosine By similarity
Modified residue4131Sulfotyrosine By similarity
Glycosylation1131N-linked (GlcNAc...) Potential
Glycosylation1211N-linked (GlcNAc...) Potential
Glycosylation1871N-linked (GlcNAc...) Potential
Glycosylation2421N-linked (GlcNAc...) Potential
Glycosylation2781N-linked (GlcNAc...) Potential
Glycosylation3161N-linked (GlcNAc...) Potential
Disulfide bond321 ↔ 353 By similarity

Experimental info

Sequence conflict1911L → R AA sequence Ref.2
Sequence conflict1941C → Y AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
O77742 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 3C349C3D6B59F5AD

FASTA42249,116
        10         20         30         40         50         60 
MGFSSLVCVL FFFLGVKVYC QYESYQWDED YDQEPDDVYQ TEFQFQQNIN YEAPFHQHTL 

        70         80         90        100        110        120 
GCASECFCPP NFPSSMYCDN RKLKTIPNIP AHIQQVYLQF NEIEAVTADS FINATHLKEI 

       130        140        150        160        170        180 
NLSHNKIKSQ KIDHGVFATL PNLLQLHLQH NNLEDFPFPL PKSLERIFLG YNEISRLQTN 

       190        200        210        220        230        240 
AVNGLVNLTM LDLCFNKIDD SVLQEKVLAK MEKLMQLNLC NNRLESMPPG LPSSLMYLSL 

       250        260        270        280        290        300 
ENNSISSIPE NYFNKLPKLH ALRISHNKLQ DIPYNIFNLS NLIELNVGHN KLKQAFYIPR 

       310        320        330        340        350        360 
NLEHLYLENN EIENVNVTVM CPSVDPLHYH HLTHIRIDQN KLKAPISSYI FLCFPHIHTI 

       370        380        390        400        410        420 
YYGEQQSTNG QTIQLKTQVF RRFQDDGDSE DHDDHHEGPE EEGTEENIDA HYYGSQEWQE 


TI 

« Hide

References

[1]"Osteoadherin, a cell binding keratan sulfate proteoglycan in bone, belongs to the family of leucine-rich repeat proteins of the extracellular matrix."
Sommarin Y., Wendel M., Shen Z., Hellman U., Heinegaard D.
J. Biol. Chem. 273:16723-16729(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 28-35; 119-126; 132-139; 191-198; 201-207; 264-268; 294-300 AND 377-381.
Tissue: Osteoblast.
[2]"Bone matrix proteins: isolation and characterization of a novel cell-binding keratan sulfate proteoglycan (osteoadherin) from bovine bone."
Wendel M., Sommarin Y., Heinegaard D.
J. Cell Biol. 141:839-847(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 119-126 AND 191-198, CHARACTERIZATION.
Tissue: Bone.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U67279 mRNA. Translation: AAC39259.1.
RefSeqNP_776372.1. NM_173947.2.
UniGeneBt.114.

3D structure databases

ProteinModelPortalO77742.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000015704.

Proteomic databases

PRIDEO77742.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID280885.
KEGGbta:280885.

Organism-specific databases

CTD4958.

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000234447.
HOVERGENHBG108061.
InParanoidO77742.
KOK08124.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF01462. LRRNT. 1 hit.
[Graphical view]
SMARTSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805020.

Entry information

Entry nameOMD_BOVIN
AccessionPrimary (citable) accession number: O77742
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: November 1, 1998
Last modified: January 22, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families