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O77742

- OMD_BOVIN

UniProt

O77742 - OMD_BOVIN

Protein

Osteomodulin

Gene

OMD

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin.

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Osteomodulin
    Alternative name(s):
    Keratan sulfate proteoglycan osteomodulin
    Short name:
    KSPG osteomodulin
    Osteoadherin
    Short name:
    OSAD
    Gene namesi
    Name:OMD
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Propeptidei21 – 277Sequence AnalysisPRO_0000032752
    Chaini28 – 422395OsteomodulinPRO_0000032753Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei22 – 221SulfotyrosineBy similarity
    Modified residuei25 – 251SulfotyrosineBy similarity
    Modified residuei31 – 311SulfotyrosineBy similarity
    Modified residuei39 – 391SulfotyrosineBy similarity
    Modified residuei51 – 511SulfotyrosineBy similarity
    Modified residuei77 – 771SulfotyrosineBy similarity
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi321 ↔ 353By similarity
    Modified residuei412 – 4121SulfotyrosineBy similarity
    Modified residuei413 – 4131SulfotyrosineBy similarity

    Post-translational modificationi

    The N-terminus is blocked.
    Some of the oligosaccharides are extended to keratan sulfate chains.
    Sulfated on tyrosine residue(s).Curated

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Proteoglycan, Sulfation

    Proteomic databases

    PRIDEiO77742.

    Expressioni

    Tissue specificityi

    Bone specific.

    Interactioni

    Subunit structurei

    Binds the alpha(V)beta(3)-integrin.

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000015704.

    Structurei

    3D structure databases

    ProteinModelPortaliO77742.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 9139LRRNTAdd
    BLAST
    Repeati92 – 11322LRR 1Add
    BLAST
    Repeati116 – 12914LRR 2Add
    BLAST
    Repeati142 – 16423LRR 3Add
    BLAST
    Repeati165 – 18420LRR 4Add
    BLAST
    Repeati187 – 20721LRR 5Add
    BLAST
    Repeati213 – 23321LRR 6Add
    BLAST
    Repeati234 – 25522LRR 7Add
    BLAST
    Repeati258 – 28023LRR 8Add
    BLAST
    Repeati281 – 29414LRR 9Add
    BLAST
    Repeati301 – 32222LRR 10Add
    BLAST
    Repeati331 – 35323LRR 11Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi62 – 7817Cys-richAdd
    BLAST
    Compositional biasi385 – 40622Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Contains 11 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000234447.
    HOVERGENiHBG108061.
    InParanoidiO77742.
    KOiK08124.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF13855. LRR_8. 2 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view]
    SMARTiSM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O77742-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGFSSLVCVL FFFLGVKVYC QYESYQWDED YDQEPDDVYQ TEFQFQQNIN    50
    YEAPFHQHTL GCASECFCPP NFPSSMYCDN RKLKTIPNIP AHIQQVYLQF 100
    NEIEAVTADS FINATHLKEI NLSHNKIKSQ KIDHGVFATL PNLLQLHLQH 150
    NNLEDFPFPL PKSLERIFLG YNEISRLQTN AVNGLVNLTM LDLCFNKIDD 200
    SVLQEKVLAK MEKLMQLNLC NNRLESMPPG LPSSLMYLSL ENNSISSIPE 250
    NYFNKLPKLH ALRISHNKLQ DIPYNIFNLS NLIELNVGHN KLKQAFYIPR 300
    NLEHLYLENN EIENVNVTVM CPSVDPLHYH HLTHIRIDQN KLKAPISSYI 350
    FLCFPHIHTI YYGEQQSTNG QTIQLKTQVF RRFQDDGDSE DHDDHHEGPE 400
    EEGTEENIDA HYYGSQEWQE TI 422
    Length:422
    Mass (Da):49,116
    Last modified:November 1, 1998 - v1
    Checksum:i3C349C3D6B59F5AD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti191 – 1911L → R AA sequence (PubMed:9566981)Curated
    Sequence conflicti194 – 1941C → Y AA sequence (PubMed:9566981)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67279 mRNA. Translation: AAC39259.1.
    RefSeqiNP_776372.1. NM_173947.2.
    UniGeneiBt.114.

    Genome annotation databases

    GeneIDi280885.
    KEGGibta:280885.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67279 mRNA. Translation: AAC39259.1 .
    RefSeqi NP_776372.1. NM_173947.2.
    UniGenei Bt.114.

    3D structure databases

    ProteinModelPortali O77742.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000015704.

    Proteomic databases

    PRIDEi O77742.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 280885.
    KEGGi bta:280885.

    Organism-specific databases

    CTDi 4958.

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000234447.
    HOVERGENi HBG108061.
    InParanoidi O77742.
    KOi K08124.

    Miscellaneous databases

    NextBioi 20805020.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF13855. LRR_8. 2 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view ]
    SMARTi SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Osteoadherin, a cell binding keratan sulfate proteoglycan in bone, belongs to the family of leucine-rich repeat proteins of the extracellular matrix."
      Sommarin Y., Wendel M., Shen Z., Hellman U., Heinegaard D.
      J. Biol. Chem. 273:16723-16729(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 28-35; 119-126; 132-139; 191-198; 201-207; 264-268; 294-300 AND 377-381.
      Tissue: Osteoblast.
    2. "Bone matrix proteins: isolation and characterization of a novel cell-binding keratan sulfate proteoglycan (osteoadherin) from bovine bone."
      Wendel M., Sommarin Y., Heinegaard D.
      J. Cell Biol. 141:839-847(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 119-126 AND 191-198, CHARACTERIZATION.
      Tissue: Bone.

    Entry informationi

    Entry nameiOMD_BOVIN
    AccessioniPrimary (citable) accession number: O77742
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3