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Protein

Keratin, type I cytoskeletal 15

Gene

KRT15

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 15
Alternative name(s):
Cytokeratin-15
Short name:
CK-15
Keratin-15
Short name:
K15
Gene namesi
Name:KRT15Imported
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636601 – 453Keratin, type I cytoskeletal 15Add BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineBy similarity1
Modified residuei42Omega-N-methylarginineBy similarity1
Modified residuei50Omega-N-methylarginineBy similarity1
Modified residuei299PhosphothreonineBy similarity1
Modified residuei321PhosphothreonineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PRIDEiO77727.

Expressioni

Tissue specificityi

Expressed in the basal cell layers of several stratified epithelia including esophagus, tongue, stomach, epidermis and hair follicle. In the hair follicle, expression is detected mainly in the basal layer of the outer root sheath (ORS), except just above the follicle bulb where it occurs throughout its thickness. Low expression levels are seen in the single layer of ORS cells around the base of the follicle which increases in the palisade-like cells of the bulb. Also expressed in the basal cells of the sebaceous glands, and expression in the epidermis occurs in a punctate pattern.1 Publication

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Structurei

3D structure databases

ProteinModelPortaliO77727.
SMRiO77727.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 102HeadSequence analysisAdd BLAST102
Regioni103 – 411RodSequence analysisAdd BLAST309
Regioni103 – 138Coil 1ASequence analysisAdd BLAST36
Regioni139 – 157Linker 1Sequence analysisAdd BLAST19
Regioni158 – 249Coil 1BSequence analysisAdd BLAST92
Regioni250 – 269Linker 12Sequence analysisAdd BLAST20
Regioni270 – 411Coil 2Sequence analysisAdd BLAST142
Regioni412 – 453TailSequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 101Gly-richSequence analysisAdd BLAST88
Compositional biasi426 – 431Poly-GlySequence analysis6

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG013015.

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
PRINTSiPR01248. TYPE1KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
PROSITEiView protein in PROSITE
PS00226. IF. 1 hit.

Sequencei

Sequence statusi: Complete.

O77727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTLLQTSS STFGGSSTRG GSLLAGGGGF GGGSLYGGGG SRTISASSAR
60 70 80 90 100
FVSSGSAGGY GGGFGGGAGS GYGGGFGGGF GGGFGSGFGD FGGGDGGLLS
110 120 130 140 150
GNEKITMQNL NDRLASYLEK VRALEEANAD LEVKIRDWYQ RQSPTSPERD
160 170 180 190 200
YSPYFKTTDE LRDKILAAAI DNSRVILEID NARLAADDFR LKYENEMALR
210 220 230 240 250
QSVEADINGL RRVLDELTLT KTDLEMQIES LNEELAYLKK NHEEEMKEFS
260 270 280 290 300
NQLAGQVNVE MDAAPGVDLT RVLSEMREQY EAMAEKNRRD AEAWFFSKTE
310 320 330 340 350
ELNKEVASNT EMIQTSKSEI TDLRRTIQGL EIELQSQLSM KAGLESTLAE
360 370 380 390 400
TDGRYAAQLQ QIQGLISSIE AQLSELRSEM EAQNQEYKML LDIKTRLEQE
410 420 430 440 450
IATYHSLLEG QDARMAGIGT GEASLGGGGG GKVRINVEES VDGKVVSSRK

REI
Length:453
Mass (Da):48,770
Last modified:November 1, 1998 - v1
Checksum:iE90D5239DA45015A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006277 Genomic DNA. Translation: CAA06944.1.

Similar proteinsi

Entry informationi

Entry nameiK1C15_SHEEP
AccessioniPrimary (citable) accession number: O77727
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 1, 1998
Last modified: August 30, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families