Calcium/calmodulin-dependent protein kinase type II subunit delta

Names and origin

Protein names

Recommended name:
    Calcium/calmodulin-dependent protein kinase type II subunit delta
      Short name=CaM kinase II subunit delta
      Short name=CaMK-II subunit delta
    EC=2.7.11.17

Gene names

Name:

CAMK2D

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

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Protein attributes

Sequence length	533 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity By similarity.
Subunit structure	CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with RRAD By similarity.
Tissue specificity	Expressed in liver. Ref.1
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain.

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Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding Calmodulin-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	calcium- and calmodulin-dependent protein kinase complex Traceable author statement. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

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Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O77708-1) Also known as: Delta 1; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O77708-2) Also known as: Delta 2; The sequence of this isoform differs from the canonical sequence as follows: 329-362: Missing.

Isoform 3 (identifier: O77708-3) Also known as: Delta 3; The sequence of this isoform differs from the canonical sequence as follows: 328-328: K → KKRKSSSSVQMM 329-362: Missing.

Isoform 4 (identifier: O77708-4) Also known as: Delta 6; The sequence of this isoform differs from the canonical sequence as follows: 329-362: Missing. 512-512: K → N 513-533: Missing.

Isoform 5 (identifier: O77708-5) Also known as: Delta 11; The sequence of this isoform differs from the canonical sequence as follows: 316-316: Missing.

Isoform 6 (identifier: O77708-6) Also known as: Delta 12; The sequence of this isoform differs from the canonical sequence as follows: 316-316: Missing. 512-512: K → N 513-533: Missing.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

Removed By similarity

Chain

2 – 533

532

Calcium/calmodulin-dependent protein kinase type II subunit delta

PRO_0000277819

Regions

Domain

14 – 272

259

Protein kinase

Nucleotide binding

20 – 28

9

ATP By similarity

Sites

Active site

136

1

Proton acceptor By similarity

Binding site

43

1

ATP By similarity

Amino acid modifications

Modified residue

2

1

N-acetylalanine By similarity

Modified residue

3

1

Phosphoserine By similarity

Modified residue

231

1

Phosphotyrosine By similarity

Modified residue

287

1

Phosphothreonine By similarity

Modified residue

306

1

Phosphothreonine By similarity

Modified residue

307

1

Phosphothreonine By similarity

Modified residue

315

1

Phosphoserine By similarity

Modified residue

319

1

Phosphoserine By similarity

Modified residue

337

1

Phosphothreonine By similarity

Modified residue

364

1

Phosphoserine By similarity

Modified residue

365

1

Phosphothreonine By similarity

Modified residue

367

1

Phosphoserine By similarity

Modified residue

368

1

Phosphoserine By similarity

Modified residue

370

1

Phosphothreonine By similarity

Modified residue

438

1

Phosphoserine By similarity

Modified residue

475

1

Phosphoserine By similarity

Modified residue

504

1

Phosphoserine By similarity

Modified residue

506

1

Phosphoserine By similarity

Modified residue

524

1

Phosphoserine By similarity

Natural variations

Alternative sequence

316

1

Missing in isoform 5 and isoform 6.

VSP_023104

Alternative sequence

328

1

K → KKRKSSSSVQMM in isoform 3.

VSP_023105

Alternative sequence

329 – 362

34

Missing in isoform 2, isoform 3 and isoform 4.

VSP_023106

Alternative sequence

512

1

K → N in isoform 4 and isoform 6.

VSP_023107

Alternative sequence

513 – 533

21

Missing in isoform 4 and isoform 6.

VSP_023108

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 (Delta 1) [UniParc]. Last modified February 20, 2007. Version 2. Checksum: 4CE3B54D96652B9E Show »	FASTA	533	60,010
10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WISHRATVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVKIN NKANVVTSPK ENIPTPALEP QTTVIHNPDG 370 380 390 400 410 420 NKESTESSNT TIEDEDVKAR KQEIIKVTEQ LIEAINNGDF EAYTKICDPG LTAFEPEALG 430 440 450 460 470 480 NLVEGMDFHR FYFENALSKS NKPIHTIILN PHVHLVGEDA ACIAYIRLTQ YMDGSGMPKT 490 500 510 520 530 MQSEETRVWH RRDGKWQNVH FHRSGSPTVP IKPPCIPNGK ENYSGGTSLW QNI « Hide
Isoform 2 (Delta 2). Checksum: 9936A9944AF8274E Show »	FASTA	499	56,376
10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WISHRATVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVKES TESSNTTIED EDVKARKQEI IKVTEQLIEA 370 380 390 400 410 420 INNGDFEAYT KICDPGLTAF EPEALGNLVE GMDFHRFYFE NALSKSNKPI HTIILNPHVH 430 440 450 460 470 480 LVGEDAACIA YIRLTQYMDG SGMPKTMQSE ETRVWHRRDG KWQNVHFHRS GSPTVPIKPP 490 CIPNGKENYS GGTSLWQNI « Hide
Isoform 3 (Delta 3). Checksum: 4C8A5A75077878F2 Show »	FASTA	510	57,627
10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WISHRATVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVKKR KSSSSVQMME STESSNTTIE DEDVKARKQE 370 380 390 400 410 420 IIKVTEQLIE AINNGDFEAY TKICDPGLTA FEPEALGNLV EGMDFHRFYF ENALSKSNKP 430 440 450 460 470 480 IHTIILNPHV HLVGEDAACI AYIRLTQYMD GSGMPKTMQS EETRVWHRRD GKWQNVHFHR 490 500 510 SGSPTVPIKP PCIPNGKENY SGGTSLWQNI « Hide
Isoform 4 (Delta 6). Checksum: 2632DF1404509454 Show »	FASTA	478	54,105
10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WISHRATVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVKES TESSNTTIED EDVKARKQEI IKVTEQLIEA 370 380 390 400 410 420 INNGDFEAYT KICDPGLTAF EPEALGNLVE GMDFHRFYFE NALSKSNKPI HTIILNPHVH 430 440 450 460 470 LVGEDAACIA YIRLTQYMDG SGMPKTMQSE ETRVWHRRDG KWQNVHFHRS GSPTVPIN « Hide
Isoform 5 (Delta 11). Checksum: 089939E553E47BB4 Show »	FASTA	532	59,939
10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WISHRATVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAKSLL KKPDGVKINN KANVVTSPKE NIPTPALEPQ TTVIHNPDGN 370 380 390 400 410 420 KESTESSNTT IEDEDVKARK QEIIKVTEQL IEAINNGDFE AYTKICDPGL TAFEPEALGN 430 440 450 460 470 480 LVEGMDFHRF YFENALSKSN KPIHTIILNP HVHLVGEDAA CIAYIRLTQY MDGSGMPKTM 490 500 510 520 530 QSEETRVWHR RDGKWQNVHF HRSGSPTVPI KPPCIPNGKE NYSGGTSLWQ NI « Hide
Isoform 6 (Delta 12). Checksum: 92C49B9EF065394D Show »	FASTA	511	57,668
10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WISHRATVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAKSLL KKPDGVKINN KANVVTSPKE NIPTPALEPQ TTVIHNPDGN 370 380 390 400 410 420 KESTESSNTT IEDEDVKARK QEIIKVTEQL IEAINNGDFE AYTKICDPGL TAFEPEALGN 430 440 450 460 470 480 LVEGMDFHRF YFENALSKSN KPIHTIILNP HVHLVGEDAA CIAYIRLTQY MDGSGMPKTM 490 500 510 QSEETRVWHR RDGKWQNVHF HRSGSPTVPI N « Hide

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References

[1]	"New alternatively spliced variants of calmodulin-dependent protein kinase II from rabbit liver." Takeuchi M., Fujisawa H. Gene 221:107-115(1998) [PubMed: 9852955] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY. Tissue: Liver.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	D14906 mRNA. Translation: BAA28870.1.
RefSeq	NP_001093424.1.
UniGene	Ocu.2311
3D structure databases
HSSP	HSSP built from PDB template 2BDW based on UniProtKB Q9NG91.
SMR	O77708. Positions 11-309, 373-506.
ModBase	Search...
Genome annotation databases
GeneID	100101557.
Phylogenomic databases
HOVERGEN	O77708.
Enzyme and pathway databases
BRENDA	2.7.11.17. 255.
Family and domain databases
InterPro	IPR020636. Ca/CaM-dep_prot_kinase-like. IPR015742. Ca/CaM-dep_prot_kinase_2. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
PANTHER	PTHR22982. Ca/CaM-dep_prot_kinase-like. 1 hit. PTHR22982:SF64. CaMKII. 1 hit.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

KCC2D_RABIT

Accession

Primary (citable) accession number: O77708

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	February 9, 2010
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents