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Protein

Alpha-2B adrenergic receptor

Gene

ADRA2B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei79Implicated in ligand bindingBy similarity1
Sitei163Implicated in catechol agonist bindingBy similarity1
Sitei167Implicated in catechol agonist bindingBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2B adrenergic receptor
Alternative name(s):
Alpha-2B adrenoreceptor
Short name:
Alpha-2B adrenoceptor
Short name:
Alpha-2BAR
Gene namesi
Name:ADRA2B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei‹1 – 25Helical; Name=1By similarityAdd BLAST›25
Topological domaini26 – 36CytoplasmicBy similarityAdd BLAST11
Transmembranei37 – 62Helical; Name=2By similarityAdd BLAST26
Topological domaini63 – 72ExtracellularBy similarity10
Transmembranei73 – 95Helical; Name=3By similarityAdd BLAST23
Topological domaini96 – 117CytoplasmicBy similarityAdd BLAST22
Transmembranei118 – 140Helical; Name=4By similarityAdd BLAST23
Topological domaini141 – 156ExtracellularBy similarityAdd BLAST16
Transmembranei157 – 180Helical; Name=5By similarityAdd BLAST24
Topological domaini181 – 356CytoplasmicBy similarityAdd BLAST176
Transmembranei357 – 380Helical; Name=6By similarityAdd BLAST24
Topological domaini381 – ›392ExtracellularBy similarityAdd BLAST›12

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000069086‹1 – ›392Alpha-2B adrenergic receptorAdd BLAST›392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi72 ↔ 151PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO77700.
PRIDEiO77700.

Expressioni

Gene expression databases

BgeeiENSBTAG00000009510.

Interactioni

Subunit structurei

Interacts with RAB26. Interacts with PPP1R9B.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012514.

Chemistry databases

BindingDBiO77700.

Structurei

3D structure databases

ProteinModelPortaliO77700.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi283 – 292Poly-Glu10

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiO77700.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000207. ADRA2B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00559. ADRENRGCA2BR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

O77700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AIAAVITFLI LFTIFGNALV ILAVLTSRSL RAPQNLFLVS LAAADILVAT
60 70 80 90 100
LIIPFSLANE LLGYWYFWRT WCEVYLALDV LFCTSSIVHL CAISLDRYWA
110 120 130 140 150
VSRALEYNSK RTPRRIKFII LIVWLIAAVI SLPPLIYKGD QGPQPLARPQ
160 170 180 190 200
CKLNQEAWYI LASSIGSFFA PCLIMILVYL RIYLIAKRSH CRGPRAKGGP
210 220 230 240 250
GERESKQPHP VPGEVSDSAK LPTLASQLAT PGEANGCSQP RPGEKGDGET
260 270 280 290 300
PEAPGTPALP PSWPAIPKSG QGQKEGVCGS SPEEEAEEEE EEGCEPQALP
310 320 330 340 350
ASPASACSPP LQQPQGSRVL ATLRGQVLLG RGTGTAGAQW WRRRTQLSRE
360 370 380 390
KRFTFVLAVV IGVFVLCWFP FFFSYSLGAI CPQHCKVPHG LF
Length:392
Mass (Da):42,840
Last modified:August 14, 2001 - v2
Checksum:i471596A7446475E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei3921

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15944 Genomic DNA. Translation: CAA75897.2.
UniGeneiBt.112377.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15944 Genomic DNA. Translation: CAA75897.2.
UniGeneiBt.112377.

3D structure databases

ProteinModelPortaliO77700.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012514.

Chemistry databases

BindingDBiO77700.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO77700.
PRIDEiO77700.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiO77700.

Gene expression databases

BgeeiENSBTAG00000009510.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000207. ADRA2B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00559. ADRENRGCA2BR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADA2B_BOVIN
AccessioniPrimary (citable) accession number: O77700
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 14, 2001
Last modified: October 5, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.