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O77695 (BGLR_CHLAE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length648 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays an important role in the degradation of dermatan and keratan sulfates By similarity.

Catalytic activity

A beta-D-glucuronoside + H2O = D-glucuronate + an alcohol.

Enzyme regulation

Inhibited by L-aspartic acid By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Lysosome.

Sequence similarities

Belongs to the glycosyl hydrolase 2 family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-glucuronidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide‹1 – 19›19 By similarity
Chain20 – 648629Beta-glucuronidase
PRO_0000012159

Sites

Active site4481Proton donor

Amino acid modifications

Glycosylation1701N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential
Glycosylation4171N-linked (GlcNAc...) Potential
Glycosylation6281N-linked (GlcNAc...) Potential

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
O77695 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: D4BB309C0D9F38D4

FASTA64874,632
        10         20         30         40         50         60 
GLAMAWAVLG PLLWGCALAL QGGMLYPRES QSRERKELDG LWSFRADFSD NRRRGFEEQW 

        70         80         90        100        110        120 
YRRPLRESGP TLDMPVPSSF NDISQDWRLR HFVGWVWYER EVILPERWTQ DLSTRVVLRI 

       130        140        150        160        170        180 
GSAHAYAIVW VNGVHTLEHE GGYLPFEADI SNLVQVGPLS SHVRITIAIN NTLTSTTLPP 

       190        200        210        220        230        240 
GTIQYLTDIS KYPKGYFIQN TYFDFFNYAG LQRSVLLYTT PTAYIDDITV TTGVEHDTGL 

       250        260        270        280        290        300 
VNYQISVKGS NLFELEVRLL DAENKLVANG TGIQGQLKVP GARLWWPYLM HERPAYLYSL 

       310        320        330        340        350        360 
EVRLTAQTSL GPVSDFYTLP VGIRTVAVTE SQFLINGKPF YFHGVNKHED ADIRGKGFDW 

       370        380        390        400        410        420 
PLLVKDFNLL RWLGANAFRT SHYPYAEEVL QMCDRYGIVV IDECPGVGLA LPQFFNNVSL 

       430        440        450        460        470        480 
QNHMRVMEEV VRRDKNHPAV VMWSVANEPA SHLESAGYYL KMVITHTKAL DPSRPVTFVT 

       490        500        510        520        530        540 
NSNYAADKGA PYVDVICLNS YYSWYHDYGH LELIQRQLTT QFENWYKTYQ KPIIQSEYGA 

       550        560        570        580        590        600 
ETIVGFHQDP PLMFTEEYQK SLLEQYHVVL DQKRRKYVVG ELIWNFADFM TEQSPTRVLG 

       610        620        630        640 
NKKGVFTRQR QPKSAAFLLR ERYWKIANET RYPHSIAKSQ CLENSPFT 

« Hide

References

[1]"Partial cDNA sequence of Cercopithecus aethiops (COS7 cell) beta-glucuronidase."
Vervoort R.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF084552 mRNA. Translation: AAC34593.1.

3D structure databases

ProteinModelPortalO77695.
SMRO77695. Positions 19-629.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH2. Glycoside Hydrolase Family 2.

Proteomic databases

PRIDEO77695.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG004843.

Family and domain databases

Gene3D2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 1 hit.
InterProIPR008979. Galactose-bd-like.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSPR00132. GLHYDRLASE2.
SUPFAMSSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGLR_CHLAE
AccessionPrimary (citable) accession number: O77695
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: October 16, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries