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Protein

G2/mitotic-specific cyclin-B2

Gene

CCNB2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B2
Gene namesi
Name:CCNB2
Synonyms:CYCB2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398G2/mitotic-specific cyclin-B2PRO_0000080360Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81PhosphothreonineBy similarity
Modified residuei77 – 771PhosphoserineBy similarity
Modified residuei92 – 921PhosphoserineBy similarity
Modified residuei94 – 941PhosphothreonineBy similarity
Modified residuei99 – 991PhosphoserineBy similarity
Modified residuei392 – 3921PhosphoserineBy similarity
Modified residuei398 – 3981PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO77689.
PRIDEiO77689.

Expressioni

Developmental stagei

Accumulates steadily during G2 and is abruptly destroyed at mitosis.

Interactioni

Subunit structurei

Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006943.

Structurei

3D structure databases

ProteinModelPortaliO77689.
SMRiO77689. Positions 131-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
HOGENOMiHOG000167672.
HOVERGENiHBG061650.
InParanoidiO77689.
KOiK05868.
OrthoDBiEOG7ZGX3C.
TreeFamiTF101001.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O77689-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLRRPTVS TDLENNDTGV NSKPKSHVTI RRAVLEEIGN RVTTRAIQVA
60 70 80 90 100
KKAQNTKVPV PPTKTTNVNK HPKPTASVKP VQMDVLAPKG PSPTPQDISM
110 120 130 140 150
KEENLCQAFS DALLCKIEDI DTEDWENPQL CSDYVKDIYQ YLRQLEVLQS
160 170 180 190 200
INPHFLDGRD INGRMRAILV DWLVQVHSKF RLLQETLYMC VAVMDRYLQV
210 220 230 240 250
QPVSRKKLQL VGITALLLAS KYEEMFSPNI EDFVYITDNA YTSSQIREME
260 270 280 290 300
TLILKELKFE LGRPLPLHFL RRASKAGEVD VEQHTLAKYL MELTLVDYDM
310 320 330 340 350
VHYHPSKVAA AASCLSQKVL GQGKWNLKQQ YYTGYTESEV LEVMRHMAKN
360 370 380 390
VVRVNENMTK FTAIKNKYAS SKLLKISTIP QLNSKAIQEL ASPLLGRS
Length:398
Mass (Da):45,260
Last modified:July 5, 2005 - v2
Checksum:i74EFF696CA93DD0A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691N → S in AAX08665 (PubMed:16305752).Curated
Sequence conflicti69 – 691N → S in AAX08686 (PubMed:16305752).Curated
Sequence conflicti69 – 691N → S in AAX08779 (PubMed:16305752).Curated
Sequence conflicti69 – 691N → S in AAX08839 (PubMed:16305752).Curated
Sequence conflicti69 – 691N → S in AAI18383 (Ref. 3) Curated
Sequence conflicti181 – 1811R → K in AAC31953 (Ref. 1) Curated
Sequence conflicti210 – 2101L → A in AAC31953 (Ref. 1) Curated
Sequence conflicti217 – 2171L → V in AAC31953 (Ref. 1) Curated
Sequence conflicti355 – 3551N → S in AAX08779 (PubMed:16305752).Curated
Sequence conflicti355 – 3551N → S in AAX08839 (PubMed:16305752).Curated
Sequence conflicti355 – 3551N → S in AAI18383 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080219 mRNA. Translation: AAC31953.1.
BT020648 mRNA. Translation: AAX08665.1.
BT020669 mRNA. Translation: AAX08686.1.
BT020762 mRNA. Translation: AAX08779.1.
BT020822 mRNA. Translation: AAX08839.1.
BT021153 mRNA. Translation: AAX31335.1.
BC118382 mRNA. Translation: AAI18383.1.
RefSeqiNP_776689.2. NM_174264.3.
UniGeneiBt.41.

Genome annotation databases

GeneIDi281668.
KEGGibta:281668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080219 mRNA. Translation: AAC31953.1.
BT020648 mRNA. Translation: AAX08665.1.
BT020669 mRNA. Translation: AAX08686.1.
BT020762 mRNA. Translation: AAX08779.1.
BT020822 mRNA. Translation: AAX08839.1.
BT021153 mRNA. Translation: AAX31335.1.
BC118382 mRNA. Translation: AAI18383.1.
RefSeqiNP_776689.2. NM_174264.3.
UniGeneiBt.41.

3D structure databases

ProteinModelPortaliO77689.
SMRiO77689. Positions 131-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006943.

Proteomic databases

PaxDbiO77689.
PRIDEiO77689.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281668.
KEGGibta:281668.

Organism-specific databases

CTDi9133.

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
HOGENOMiHOG000167672.
HOVERGENiHBG061650.
InParanoidiO77689.
KOiK05868.
OrthoDBiEOG7ZGX3C.
TreeFamiTF101001.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bovine cyclin B2 complete cds."
    Lastro M.T., Ignotz G.G., Currie W.B.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal cerebellum.

Entry informationi

Entry nameiCCNB2_BOVIN
AccessioniPrimary (citable) accession number: O77689
Secondary accession number(s): Q17QG1
, Q5BIS1, Q5E9U8, Q5EAA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 5, 2005
Last modified: July 6, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.