Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G2/mitotic-specific cyclin-B2

Gene

CCNB2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition.By similarity

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B2
Gene namesi
Name:CCNB2
Synonyms:CYCB2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000803601 – 398G2/mitotic-specific cyclin-B2Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphothreonineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei92PhosphoserineBy similarity1
Modified residuei94PhosphothreonineBy similarity1
Modified residuei99PhosphoserineBy similarity1
Modified residuei392PhosphoserineBy similarity1
Modified residuei398PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO77689.
PRIDEiO77689.

Expressioni

Developmental stagei

Accumulates steadily during G2 and is abruptly destroyed at mitosis.

Interactioni

Subunit structurei

Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006943.

Structurei

3D structure databases

ProteinModelPortaliO77689.
SMRiO77689.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
HOGENOMiHOG000167672.
HOVERGENiHBG061650.
InParanoidiO77689.
KOiK21770.
TreeFamiTF101001.

Family and domain databases

CDDicd00043. CYCLIN. 2 hits.
Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR013763. Cyclin-like.
IPR036915. Cyclin-like_sf.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
PfamiView protein in Pfam
PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiView protein in PROSITE
PS00292. CYCLINS. 1 hit.

Sequencei

Sequence statusi: Complete.

O77689-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLRRPTVS TDLENNDTGV NSKPKSHVTI RRAVLEEIGN RVTTRAIQVA
60 70 80 90 100
KKAQNTKVPV PPTKTTNVNK HPKPTASVKP VQMDVLAPKG PSPTPQDISM
110 120 130 140 150
KEENLCQAFS DALLCKIEDI DTEDWENPQL CSDYVKDIYQ YLRQLEVLQS
160 170 180 190 200
INPHFLDGRD INGRMRAILV DWLVQVHSKF RLLQETLYMC VAVMDRYLQV
210 220 230 240 250
QPVSRKKLQL VGITALLLAS KYEEMFSPNI EDFVYITDNA YTSSQIREME
260 270 280 290 300
TLILKELKFE LGRPLPLHFL RRASKAGEVD VEQHTLAKYL MELTLVDYDM
310 320 330 340 350
VHYHPSKVAA AASCLSQKVL GQGKWNLKQQ YYTGYTESEV LEVMRHMAKN
360 370 380 390
VVRVNENMTK FTAIKNKYAS SKLLKISTIP QLNSKAIQEL ASPLLGRS
Length:398
Mass (Da):45,260
Last modified:July 5, 2005 - v2
Checksum:i74EFF696CA93DD0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69N → S in AAX08665 (PubMed:16305752).Curated1
Sequence conflicti69N → S in AAX08686 (PubMed:16305752).Curated1
Sequence conflicti69N → S in AAX08779 (PubMed:16305752).Curated1
Sequence conflicti69N → S in AAX08839 (PubMed:16305752).Curated1
Sequence conflicti69N → S in AAI18383 (Ref. 3) Curated1
Sequence conflicti181R → K in AAC31953 (Ref. 1) Curated1
Sequence conflicti210L → A in AAC31953 (Ref. 1) Curated1
Sequence conflicti217L → V in AAC31953 (Ref. 1) Curated1
Sequence conflicti355N → S in AAX08779 (PubMed:16305752).Curated1
Sequence conflicti355N → S in AAX08839 (PubMed:16305752).Curated1
Sequence conflicti355N → S in AAI18383 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080219 mRNA. Translation: AAC31953.1.
BT020648 mRNA. Translation: AAX08665.1.
BT020669 mRNA. Translation: AAX08686.1.
BT020762 mRNA. Translation: AAX08779.1.
BT020822 mRNA. Translation: AAX08839.1.
BT021153 mRNA. Translation: AAX31335.1.
BC118382 mRNA. Translation: AAI18383.1.
RefSeqiNP_776689.2. NM_174264.3.
UniGeneiBt.41.

Genome annotation databases

GeneIDi281668.
KEGGibta:281668.

Similar proteinsi

Entry informationi

Entry nameiCCNB2_BOVIN
AccessioniPrimary (citable) accession number: O77689
Secondary accession number(s): Q17QG1
, Q5BIS1, Q5E9U8, Q5EAA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 5, 2005
Last modified: October 25, 2017
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families