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Protein

D(1A) dopamine receptor

Gene

DRD1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
D(1A) dopamine receptor
Alternative name(s):
Dopamine D1 receptor
Gene namesi
Name:DRD1
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 6

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4926Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini50 – 6011CytoplasmicSequence analysisAdd
BLAST
Transmembranei61 – 8727Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini88 – 969ExtracellularSequence analysis
Transmembranei97 – 11923Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence analysisAdd
BLAST
Transmembranei139 – 16325Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini164 – 19229ExtracellularSequence analysisAdd
BLAST
Transmembranei193 – 21826Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 27254CytoplasmicSequence analysisAdd
BLAST
Transmembranei273 – 29927Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini300 – 31213ExtracellularSequence analysisAdd
BLAST
Transmembranei313 – 33725Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini338 – 446109CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446D(1A) dopamine receptorPRO_0000069374Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi96 ↔ 186PROSITE-ProRule annotation
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence analysis
Lipidationi347 – 3471S-palmitoyl cysteineBy similarity
Lipidationi351 – 3511S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiO77680.

Expressioni

Gene expression databases

ExpressionAtlasiO77680. baseline.

Interactioni

Subunit structurei

Interacts with DNAJC14 via its C-terminus. Interacts with DRD1IP.By similarity

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000006816.

Structurei

3D structure databases

ProteinModelPortaliO77680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiO77680.
KOiK04144.
OMAiSSLNRMY.
OrthoDBiEOG780RMN.
TreeFamiTF325181.

Family and domain databases

InterProiIPR001413. Dopamine_D1_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00565. DOPAMINED1AR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O77680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLNTSAMD GTGLVVERDF SVRILTACFL SLLILSTLLG NTLVCAAVIR
60 70 80 90 100
FRHLRSKVTN FFVISLAVSD LLVAVLVMPW KAVAEIAGFW PFGSFCNIWV
110 120 130 140 150
AFDIMCSTAS ILNLCVISVD RYWAISSPFR YERKMTPKAA FILISVAWTL
160 170 180 190 200
SVLISFIPVQ LSWHKAKPTS PSDGNATSLA ETIDNCDSSL SRTYAISSSV
210 220 230 240 250
ISFYIPVAIM IVTYTRIYRI AQKQIRRIAA LERAAVHAKN CQTTTGNGKP
260 270 280 290 300
VECSQPESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI LNCILPFCGS
310 320 330 340 350
GETQPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFRKA FSTLLGCYRL
360 370 380 390 400
CPATNNAIET VSINNNGAAM FSSHHEPRGS ISKECNLVYL IPHAVGSSED
410 420 430 440
LKKEEAAGIA RPLEKLSPAL SVILDYDTDV SLEKIQPITQ NGQHPT
Length:446
Mass (Da):49,292
Last modified:November 1, 1998 - v1
Checksum:iDFB6B9D765D600A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077862 Genomic DNA. Translation: AAC27328.1.
RefSeqiNP_001193904.1. NM_001206975.1.
XP_014996937.1. XM_015141451.1.
UniGeneiMmu.30055.

Genome annotation databases

EnsembliENSMMUT00000007253; ENSMMUP00000006816; ENSMMUG00000005147.
GeneIDi697796.
KEGGimcc:697796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077862 Genomic DNA. Translation: AAC27328.1.
RefSeqiNP_001193904.1. NM_001206975.1.
XP_014996937.1. XM_015141451.1.
UniGeneiMmu.30055.

3D structure databases

ProteinModelPortaliO77680.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000006816.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiO77680.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000007253; ENSMMUP00000006816; ENSMMUG00000005147.
GeneIDi697796.
KEGGimcc:697796.

Organism-specific databases

CTDi1812.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiO77680.
KOiK04144.
OMAiSSLNRMY.
OrthoDBiEOG780RMN.
TreeFamiTF325181.

Miscellaneous databases

NextBioi19972217.

Gene expression databases

ExpressionAtlasiO77680. baseline.

Family and domain databases

InterProiIPR001413. Dopamine_D1_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00565. DOPAMINED1AR.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and expression of the rhesus macaque D1 dopamine receptor gene."
    Machida C.A., Searles R.P., Nipper V., Brown J.A., Kozell L.B., Neve K.A.
    Mol. Pharmacol. 41:652-659(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDRD1_MACMU
AccessioniPrimary (citable) accession number: O77680
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.