Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Orexin

Gene

HCRT

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (By similarity).By similarity

GO - Biological processi

  1. feeding behavior Source: InterPro
  2. neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_275833. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_339860. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin
Alternative name(s):
Hypocretin
Short name:
Hcrt
Cleaved into the following 2 chains:
Alternative name(s):
Hypocretin-1
Short name:
Hcrt1
Alternative name(s):
Hypocretin-2
Short name:
Hcrt2
Gene namesi
Name:HCRT
Synonyms:ORX, OX, PPOX
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Chromosome 12

Subcellular locationi

Rough endoplasmic reticulum By similarity. Cytoplasmic vesicle By similarity. Cell junctionsynapse By similarity
Note: Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
  3. perinuclear region of cytoplasm Source: Ensembl
  4. rough endoplasmic reticulum Source: UniProtKB-SubCell
  5. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333By similarityAdd
BLAST
Peptidei34 – 6633Orexin-APRO_0000020267Add
BLAST
Peptidei70 – 9728Orexin-BPRO_0000020268Add
BLAST
Propeptidei98 – 13134PRO_0000020269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341Pyrrolidone carboxylic acidBy similarity
Disulfide bondi39 ↔ 45By similarity
Disulfide bondi40 ↔ 47By similarity
Modified residuei66 – 661Leucine amideBy similarity
Modified residuei97 – 971Methionine amideBy similarity

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

Structurei

3D structure databases

SMRiO77668. Positions 34-66, 72-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the orexin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG70925.
GeneTreeiENSGT00390000014272.
HOGENOMiHOG000230990.
HOVERGENiHBG000256.
InParanoidiO77668.
KOiK05246.
OMAiKVSWATV.
OrthoDBiEOG7XSTHD.
TreeFamiTF330756.

Family and domain databases

InterProiIPR001704. Orexin.
[Graphical view]
PANTHERiPTHR15173:SF2. PTHR15173:SF2. 1 hit.
PfamiPF02072. Orexin. 1 hit.
[Graphical view]
PIRSFiPIRSF037824. Orexin. 1 hit.
PRINTSiPR01091. OREXINPP.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77668-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPPFAKVSW ATVTLLLLLL LLPPAVLSPG AAAQPLPDCC RQKTCSCRLY
60 70 80 90 100
ELLHGAGNHA AGILTLGKRR PGPPGLQGRL QRLLQASGNH AAGILTMGRR
110 120 130
AGAEPAPRLC PGRRCLAAAA SSVAPGGRSG I
Length:131
Mass (Da):13,457
Last modified:November 1, 1998 - v1
Checksum:i665A74448429AB1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075241 mRNA. Translation: AAC26827.1.
DQ985365 Genomic DNA. Translation: ABJ15704.1.
EF434654 Genomic DNA. Translation: ABO15568.1.
EF434655 mRNA. Translation: ABO15569.1.
AF169352 Genomic DNA. Translation: AAF24216.1.
RefSeqiNP_999321.1. NM_214156.2.
UniGeneiSsc.15983.

Genome annotation databases

EnsembliENSSSCT00000018952; ENSSSCP00000018447; ENSSSCG00000017410.
GeneIDi397305.
KEGGissc:397305.

Cross-referencesi

Web resourcesi

Protein Spotlight

Qui dort dine - Issue 15 of October 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075241 mRNA. Translation: AAC26827.1.
DQ985365 Genomic DNA. Translation: ABJ15704.1.
EF434654 Genomic DNA. Translation: ABO15568.1.
EF434655 mRNA. Translation: ABO15569.1.
AF169352 Genomic DNA. Translation: AAF24216.1.
RefSeqiNP_999321.1. NM_214156.2.
UniGeneiSsc.15983.

3D structure databases

SMRiO77668. Positions 34-66, 72-97.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000018952; ENSSSCP00000018447; ENSSSCG00000017410.
GeneIDi397305.
KEGGissc:397305.

Organism-specific databases

CTDi3060.

Phylogenomic databases

eggNOGiNOG70925.
GeneTreeiENSGT00390000014272.
HOGENOMiHOG000230990.
HOVERGENiHBG000256.
InParanoidiO77668.
KOiK05246.
OMAiKVSWATV.
OrthoDBiEOG7XSTHD.
TreeFamiTF330756.

Enzyme and pathway databases

ReactomeiREACT_275833. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_339860. G alpha (q) signalling events.

Family and domain databases

InterProiIPR001704. Orexin.
[Graphical view]
PANTHERiPTHR15173:SF2. PTHR15173:SF2. 1 hit.
PfamiPF02072. Orexin. 1 hit.
[Graphical view]
PIRSFiPIRSF037824. Orexin. 1 hit.
PRINTSiPR01091. OREXINPP.
ProtoNetiSearch...

Publicationsi

  1. "Cloning of porcine prepro-orexin cDNA and effects of an intramuscular injection of synthetic porcine orexin-B on feed intake in young pigs."
    Dyer C.J., Touchette K.J., Carroll J.A., Allee G.L., Matteri R.L.
    Domest. Anim. Endocrinol. 16:145-148(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF OREXIN-B.
    Tissue: Hypothalamus.
  2. Guo H.H., Wang L.X.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Linkage and physical mapping of the porcine prepro-orexin gene."
    Malek M., Marklund S., Dyer C., Matteri R.L., Rothschild M.F.
    Mamm. Genome 11:342-343(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-131.

Entry informationi

Entry nameiOREX_PIG
AccessioniPrimary (citable) accession number: O77668
Secondary accession number(s): Q000Y9, Q9TTA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: April 1, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.