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Protein

Orexin

Gene

HCRT

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-SSC-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-SSC-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin
Alternative name(s):
Hypocretin
Short name:
Hcrt
Cleaved into the following 2 chains:
Alternative name(s):
Hypocretin-1
Short name:
Hcrt1
Alternative name(s):
Hypocretin-2
Short name:
Hcrt2
Gene namesi
Name:HCRT
Synonyms:ORX, OX, PPOX
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33By similarityAdd BLAST33
PeptideiPRO_000002026734 – 66Orexin-AAdd BLAST33
PeptideiPRO_000002026870 – 97Orexin-BAdd BLAST28
PropeptideiPRO_000002026998 – 131Add BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi39 ↔ 45By similarity
Disulfide bondi40 ↔ 47By similarity
Modified residuei66Leucine amideBy similarity1
Modified residuei97Methionine amideBy similarity1

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiO77668
PeptideAtlasiO77668
PRIDEiO77668

Expressioni

Gene expression databases

BgeeiENSSSCG00000017410
GenevisibleiO77668 SS

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000018447

Structurei

3D structure databases

ProteinModelPortaliO77668
SMRiO77668
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the orexin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4FI Eukaryota
ENOG410Y5WS LUCA
GeneTreeiENSGT00390000014272
HOGENOMiHOG000230990
HOVERGENiHBG000256
InParanoidiO77668
KOiK05246
OMAiSECCRQP
OrthoDBiEOG091G0K5S
TreeFamiTF330756

Family and domain databases

InterProiView protein in InterPro
IPR001704 Orexin
PANTHERiPTHR15173 PTHR15173, 1 hit
PfamiView protein in Pfam
PF02072 Orexin, 1 hit
PIRSFiPIRSF037824 Orexin, 1 hit
PRINTSiPR01091 OREXINPP

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77668-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPPFAKVSW ATVTLLLLLL LLPPAVLSPG AAAQPLPDCC RQKTCSCRLY
60 70 80 90 100
ELLHGAGNHA AGILTLGKRR PGPPGLQGRL QRLLQASGNH AAGILTMGRR
110 120 130
AGAEPAPRLC PGRRCLAAAA SSVAPGGRSG I
Length:131
Mass (Da):13,457
Last modified:November 1, 1998 - v1
Checksum:i665A74448429AB1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075241 mRNA Translation: AAC26827.1
DQ985365 Genomic DNA Translation: ABJ15704.1
EF434654 Genomic DNA Translation: ABO15568.1
EF434655 mRNA Translation: ABO15569.1
AF169352 Genomic DNA Translation: AAF24216.1
RefSeqiNP_999321.1, NM_214156.2
XP_013836403.1, XM_013980949.1
XP_013836404.1, XM_013980950.1
XP_013836405.1, XM_013980951.1
UniGeneiSsc.15983

Genome annotation databases

EnsembliENSSSCT00000018952; ENSSSCP00000018447; ENSSSCG00000017410
GeneIDi397305
KEGGissc:397305

Similar proteinsi

Entry informationi

Entry nameiOREX_PIG
AccessioniPrimary (citable) accession number: O77668
Secondary accession number(s): Q000Y9, Q9TTA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 22, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome