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Protein

Orexin

Gene

HCRT

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-SSC-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-SSC-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin
Alternative name(s):
Hypocretin
Short name:
Hcrt
Cleaved into the following 2 chains:
Alternative name(s):
Hypocretin-1
Short name:
Hcrt1
Alternative name(s):
Hypocretin-2
Short name:
Hcrt2
Gene namesi
Name:HCRT
Synonyms:ORX, OX, PPOX
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 12

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33By similarityAdd BLAST33
PeptideiPRO_000002026734 – 66Orexin-AAdd BLAST33
PeptideiPRO_000002026870 – 97Orexin-BAdd BLAST28
PropeptideiPRO_000002026998 – 131Add BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi39 ↔ 45By similarity
Disulfide bondi40 ↔ 47By similarity
Modified residuei66Leucine amideBy similarity1
Modified residuei97Methionine amideBy similarity1

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiO77668.
PeptideAtlasiO77668.
PRIDEiO77668.

Expressioni

Gene expression databases

GenevisibleiO77668. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000018447.

Structurei

3D structure databases

ProteinModelPortaliO77668.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the orexin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4FI. Eukaryota.
ENOG410Y5WS. LUCA.
GeneTreeiENSGT00390000014272.
HOGENOMiHOG000230990.
HOVERGENiHBG000256.
InParanoidiO77668.
KOiK05246.
OMAiKVSWATV.
OrthoDBiEOG09020F54.
TreeFamiTF330756.

Family and domain databases

InterProiView protein in InterPro
IPR001704. Orexin.
PfamiView protein in Pfam
PF02072. Orexin. 1 hit.
PIRSFiPIRSF037824. Orexin. 1 hit.
PRINTSiPR01091. OREXINPP.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77668-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPPFAKVSW ATVTLLLLLL LLPPAVLSPG AAAQPLPDCC RQKTCSCRLY
60 70 80 90 100
ELLHGAGNHA AGILTLGKRR PGPPGLQGRL QRLLQASGNH AAGILTMGRR
110 120 130
AGAEPAPRLC PGRRCLAAAA SSVAPGGRSG I
Length:131
Mass (Da):13,457
Last modified:November 1, 1998 - v1
Checksum:i665A74448429AB1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075241 mRNA. Translation: AAC26827.1.
DQ985365 Genomic DNA. Translation: ABJ15704.1.
EF434654 Genomic DNA. Translation: ABO15568.1.
EF434655 mRNA. Translation: ABO15569.1.
AF169352 Genomic DNA. Translation: AAF24216.1.
RefSeqiNP_999321.1. NM_214156.2.
XP_013836403.1. XM_013980949.1.
XP_013836404.1. XM_013980950.1.
XP_013836405.1. XM_013980951.1.
UniGeneiSsc.15983.

Genome annotation databases

EnsembliENSSSCT00000018952; ENSSSCP00000018447; ENSSSCG00000017410.
GeneIDi397305.
KEGGissc:397305.

Cross-referencesi

Web resourcesi

Protein Spotlight

Qui dort dine - Issue 15 of October 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075241 mRNA. Translation: AAC26827.1.
DQ985365 Genomic DNA. Translation: ABJ15704.1.
EF434654 Genomic DNA. Translation: ABO15568.1.
EF434655 mRNA. Translation: ABO15569.1.
AF169352 Genomic DNA. Translation: AAF24216.1.
RefSeqiNP_999321.1. NM_214156.2.
XP_013836403.1. XM_013980949.1.
XP_013836404.1. XM_013980950.1.
XP_013836405.1. XM_013980951.1.
UniGeneiSsc.15983.

3D structure databases

ProteinModelPortaliO77668.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000018447.

Proteomic databases

PaxDbiO77668.
PeptideAtlasiO77668.
PRIDEiO77668.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000018952; ENSSSCP00000018447; ENSSSCG00000017410.
GeneIDi397305.
KEGGissc:397305.

Organism-specific databases

CTDi3060.

Phylogenomic databases

eggNOGiENOG410J4FI. Eukaryota.
ENOG410Y5WS. LUCA.
GeneTreeiENSGT00390000014272.
HOGENOMiHOG000230990.
HOVERGENiHBG000256.
InParanoidiO77668.
KOiK05246.
OMAiKVSWATV.
OrthoDBiEOG09020F54.
TreeFamiTF330756.

Enzyme and pathway databases

ReactomeiR-SSC-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-SSC-416476. G alpha (q) signalling events.

Gene expression databases

GenevisibleiO77668. SS.

Family and domain databases

InterProiView protein in InterPro
IPR001704. Orexin.
PfamiView protein in Pfam
PF02072. Orexin. 1 hit.
PIRSFiPIRSF037824. Orexin. 1 hit.
PRINTSiPR01091. OREXINPP.
ProtoNetiSearch...

Entry informationi

Entry nameiOREX_PIG
AccessioniPrimary (citable) accession number: O77668
Secondary accession number(s): Q000Y9, Q9TTA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: February 15, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.