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O77668

- OREX_PIG

UniProt

O77668 - OREX_PIG

Protein

Orexin

Gene

HCRT

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity By similarity.By similarity

    GO - Biological processi

    1. feeding behavior Source: InterPro
    2. neuropeptide signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Neuropeptide

    Enzyme and pathway databases

    ReactomeiREACT_213628. Orexin and neuropeptides FF and QRFP bind to their respective receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orexin
    Alternative name(s):
    Hypocretin
    Short name:
    Hcrt
    Cleaved into the following 2 chains:
    Alternative name(s):
    Hypocretin-1
    Short name:
    Hcrt1
    Alternative name(s):
    Hypocretin-2
    Short name:
    Hcrt2
    Gene namesi
    Name:HCRT
    Synonyms:ORX, OX, PPOX
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 12

    Subcellular locationi

    Rough endoplasmic reticulum By similarity. Cytoplasmic vesicle By similarity. Cell junctionsynapse By similarity
    Note: Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    3. perinuclear region of cytoplasm Source: Ensembl
    4. rough endoplasmic reticulum Source: UniProtKB-SubCell
    5. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333By similarityAdd
    BLAST
    Peptidei34 – 6633Orexin-APRO_0000020267Add
    BLAST
    Peptidei70 – 9728Orexin-BPRO_0000020268Add
    BLAST
    Propeptidei98 – 13134PRO_0000020269Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei34 – 341Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi39 ↔ 45By similarity
    Disulfide bondi40 ↔ 47By similarity
    Modified residuei66 – 661Leucine amideBy similarity
    Modified residuei97 – 971Methionine amideBy similarity

    Post-translational modificationi

    Specific enzymatic cleavages at paired basic residues yield the different active peptides.

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

    Structurei

    3D structure databases

    ProteinModelPortaliO77668.
    SMRiO77668. Positions 34-66, 72-97.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the orexin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG70925.
    GeneTreeiENSGT00390000014272.
    HOGENOMiHOG000230990.
    HOVERGENiHBG000256.
    KOiK05246.
    OMAiSECCRQP.
    OrthoDBiEOG7XSTHD.
    TreeFamiTF330756.

    Family and domain databases

    InterProiIPR001704. Orexin.
    [Graphical view]
    PANTHERiPTHR15173. PTHR15173. 1 hit.
    PfamiPF02072. Orexin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037824. Orexin. 1 hit.
    PRINTSiPR01091. OREXINPP.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O77668-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPPFAKVSW ATVTLLLLLL LLPPAVLSPG AAAQPLPDCC RQKTCSCRLY    50
    ELLHGAGNHA AGILTLGKRR PGPPGLQGRL QRLLQASGNH AAGILTMGRR 100
    AGAEPAPRLC PGRRCLAAAA SSVAPGGRSG I 131
    Length:131
    Mass (Da):13,457
    Last modified:November 1, 1998 - v1
    Checksum:i665A74448429AB1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF075241 mRNA. Translation: AAC26827.1.
    DQ985365 Genomic DNA. Translation: ABJ15704.1.
    EF434654 Genomic DNA. Translation: ABO15568.1.
    EF434655 mRNA. Translation: ABO15569.1.
    AF169352 Genomic DNA. Translation: AAF24216.1.
    RefSeqiNP_999321.1. NM_214156.2.
    UniGeneiSsc.15983.

    Genome annotation databases

    EnsembliENSSSCT00000018952; ENSSSCP00000018447; ENSSSCG00000017410.
    GeneIDi397305.
    KEGGissc:397305.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Qui dort dine - Issue 15 of October 2001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF075241 mRNA. Translation: AAC26827.1 .
    DQ985365 Genomic DNA. Translation: ABJ15704.1 .
    EF434654 Genomic DNA. Translation: ABO15568.1 .
    EF434655 mRNA. Translation: ABO15569.1 .
    AF169352 Genomic DNA. Translation: AAF24216.1 .
    RefSeqi NP_999321.1. NM_214156.2.
    UniGenei Ssc.15983.

    3D structure databases

    ProteinModelPortali O77668.
    SMRi O77668. Positions 34-66, 72-97.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000018952 ; ENSSSCP00000018447 ; ENSSSCG00000017410 .
    GeneIDi 397305.
    KEGGi ssc:397305.

    Organism-specific databases

    CTDi 3060.

    Phylogenomic databases

    eggNOGi NOG70925.
    GeneTreei ENSGT00390000014272.
    HOGENOMi HOG000230990.
    HOVERGENi HBG000256.
    KOi K05246.
    OMAi SECCRQP.
    OrthoDBi EOG7XSTHD.
    TreeFami TF330756.

    Enzyme and pathway databases

    Reactomei REACT_213628. Orexin and neuropeptides FF and QRFP bind to their respective receptors.

    Family and domain databases

    InterProi IPR001704. Orexin.
    [Graphical view ]
    PANTHERi PTHR15173. PTHR15173. 1 hit.
    Pfami PF02072. Orexin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037824. Orexin. 1 hit.
    PRINTSi PR01091. OREXINPP.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of porcine prepro-orexin cDNA and effects of an intramuscular injection of synthetic porcine orexin-B on feed intake in young pigs."
      Dyer C.J., Touchette K.J., Carroll J.A., Allee G.L., Matteri R.L.
      Domest. Anim. Endocrinol. 16:145-148(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF OREXIN-B.
      Tissue: Hypothalamus.
    2. Guo H.H., Wang L.X.
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "Linkage and physical mapping of the porcine prepro-orexin gene."
      Malek M., Marklund S., Dyer C., Matteri R.L., Rothschild M.F.
      Mamm. Genome 11:342-343(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-131.

    Entry informationi

    Entry nameiOREX_PIG
    AccessioniPrimary (citable) accession number: O77668
    Secondary accession number(s): Q000Y9, Q9TTA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3