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O77668 (OREX_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orexin
Alternative name(s):
Hypocretin
Short name=Hcrt

Cleaved into the following 2 chains:

  1. Orexin-A
    Alternative name(s):
    Hypocretin-1
    Short name=Hcrt1
  2. Orexin-B
    Alternative name(s):
    Hypocretin-2
    Short name=Hcrt2
Gene names
Name:HCRT
Synonyms:ORX, OX, PPOX
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity By similarity.

Subcellular location

Rough endoplasmic reticulum By similarity. Cytoplasmic vesicle By similarity. Cell junctionsynapse By similarity. Note: Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses By similarity.

Post-translational modification

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Sequence similarities

Belongs to the orexin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 By similarity
Peptide34 – 6633Orexin-A
PRO_0000020267
Peptide70 – 9728Orexin-B
PRO_0000020268
Propeptide98 – 13134
PRO_0000020269

Amino acid modifications

Modified residue341Pyrrolidone carboxylic acid By similarity
Modified residue661Leucine amide By similarity
Modified residue971Methionine amide By similarity
Disulfide bond39 ↔ 45 By similarity
Disulfide bond40 ↔ 47 By similarity

Sequences

Sequence LengthMass (Da)Tools
O77668 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 665A74448429AB1F

FASTA13113,457
        10         20         30         40         50         60 
MNPPFAKVSW ATVTLLLLLL LLPPAVLSPG AAAQPLPDCC RQKTCSCRLY ELLHGAGNHA 

        70         80         90        100        110        120 
AGILTLGKRR PGPPGLQGRL QRLLQASGNH AAGILTMGRR AGAEPAPRLC PGRRCLAAAA 

       130 
SSVAPGGRSG I 

« Hide

References

[1]"Cloning of porcine prepro-orexin cDNA and effects of an intramuscular injection of synthetic porcine orexin-B on feed intake in young pigs."
Dyer C.J., Touchette K.J., Carroll J.A., Allee G.L., Matteri R.L.
Domest. Anim. Endocrinol. 16:145-148(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF OREXIN-B.
Tissue: Hypothalamus.
[2]Guo H.H., Wang L.X.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]"Linkage and physical mapping of the porcine prepro-orexin gene."
Malek M., Marklund S., Dyer C., Matteri R.L., Rothschild M.F.
Mamm. Genome 11:342-343(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-131.

Web resources

Protein Spotlight

Qui dort dine - Issue 15 of October 2001

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF075241 mRNA. Translation: AAC26827.1.
DQ985365 Genomic DNA. Translation: ABJ15704.1.
EF434654 Genomic DNA. Translation: ABO15568.1.
EF434655 mRNA. Translation: ABO15569.1.
AF169352 Genomic DNA. Translation: AAF24216.1.
RefSeqNP_999321.1. NM_214156.2.
UniGeneSsc.15983.

3D structure databases

ProteinModelPortalO77668.
SMRO77668. Positions 34-66, 72-97.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000018952; ENSSSCP00000018447; ENSSSCG00000017410.
GeneID397305.
KEGGssc:397305.

Organism-specific databases

CTD3060.

Phylogenomic databases

eggNOGNOG70925.
GeneTreeENSGT00390000014272.
HOGENOMHOG000230990.
HOVERGENHBG000256.
KOK05246.
OMASECCRQP.
OrthoDBEOG7XSTHD.
TreeFamTF330756.

Family and domain databases

InterProIPR001704. Orexin.
[Graphical view]
PANTHERPTHR15173. PTHR15173. 1 hit.
PfamPF02072. Orexin. 1 hit.
[Graphical view]
PIRSFPIRSF037824. Orexin. 1 hit.
PRINTSPR01091. OREXINPP.
ProtoNetSearch...

Entry information

Entry nameOREX_PIG
AccessionPrimary (citable) accession number: O77668
Secondary accession number(s): Q000Y9, Q9TTA6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries