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O77667

- DHI2_BOVIN

UniProt

O77667 - DHI2_BOVIN

Protein

Corticosteroid 11-beta-dehydrogenase isozyme 2

Gene

HSD11B2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Affinity towards corticosterone is higher than cortisol or dexamethasone.

    Catalytic activityi

    An 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH.

    Enzyme regulationi

    Inhibited by glycyrrhetinic acid, carbenoloxone and 11-alpha-OH-progesterone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei219 – 2191SubstrateBy similarity
    Active sitei232 – 2321Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi82 – 11130NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC:1.1.1.-)
    Alternative name(s):
    11-beta-hydroxysteroid dehydrogenase type 2
    Short name:
    11-DH2
    Short name:
    11-beta-HSD2
    NAD-dependent 11-beta-hydroxysteroid dehydrogenase
    Gene namesi
    Name:HSD11B2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404Corticosteroid 11-beta-dehydrogenase isozyme 2PRO_0000054626Add
    BLAST

    Proteomic databases

    PRIDEiO77667.

    Expressioni

    Tissue specificityi

    Highly expressed in kidney, adrenal and colon; detected at lower levels on lung and liver.

    Interactioni

    Subunit structurei

    Interacts with ligand-free cytoplasmic NR3C2.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000007470.

    Structurei

    3D structure databases

    ProteinModelPortaliO77667.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1028.
    HOVERGENiHBG005482.
    InParanoidiO77667.
    KOiK00071.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O77667-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESWPWPSGG AWLLVPARAL LQLLRADLRL GRPLLAALAL LAALDWLCQR    50
    LLPPLAALAV LAATGWIVLS RLARPQRLPV ATRAVLITGC DSGFGNATAK 100
    KLDTMGFTVL ATVLDLNSPG ALELRACCSS RLKLLQMDLT KPGDISRVLE 150
    FTKVHTPSTG LWGLVNNAGQ NIFVADAELC PVATFRTCME VNFFGALEMT 200
    KGLLPLLRRS SGRIVTVSSP AGDMPFPCLA AYGTSKAALA LLMGNFSCEL 250
    LPWGVKVSII QPACFKTESV KDVHQWEERK QQLLATLPQE LLQAYGEDYI 300
    EHLNGQFLHS LSQALPDLSP VVDAITDALL AAQPLRRYYP GHGLGLIYFI 350
    HYYLPEGLRQ RFLQSFFISP YVPRALQAGQ PGLTSARDIA QDQGPRPDPS 400
    PTAQ 404
    Length:404
    Mass (Da):43,987
    Last modified:November 1, 1998 - v1
    Checksum:iE04C2852CFD4D064
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF074706 mRNA. Translation: AAC26137.1.
    RefSeqiNP_777067.1. NM_174642.2.
    UniGeneiBt.49451.

    Genome annotation databases

    GeneIDi282434.
    KEGGibta:282434.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF074706 mRNA. Translation: AAC26137.1 .
    RefSeqi NP_777067.1. NM_174642.2.
    UniGenei Bt.49451.

    3D structure databases

    ProteinModelPortali O77667.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000007470.

    Proteomic databases

    PRIDEi O77667.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 282434.
    KEGGi bta:282434.

    Organism-specific databases

    CTDi 3291.

    Phylogenomic databases

    eggNOGi COG1028.
    HOVERGENi HBG005482.
    InParanoidi O77667.
    KOi K00071.

    Miscellaneous databases

    NextBioi 20806210.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of the bovine 11beta-hydroxysteroid dehydrogenase type-2."
      Romero D.G., Zhou M.-Y., Gomez-Sanchez C.E.
      J. Steroid Biochem. Mol. Biol. 72:231-237(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Tissue: Kidney.

    Entry informationi

    Entry nameiDHI2_BOVIN
    AccessioniPrimary (citable) accession number: O77667
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3