SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O77649

- UDB20_MACFA

UniProt

O77649 - UDB20_MACFA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
UDP-glucuronosyltransferase 2B20
Gene
UGT2B20
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with androgens, such as testosterone, dihydrotestosterone (DHT) and 3-alpha-diol. It is also active on catecholoestrogens including 1,3,5,10-oestratriene-3,4-diol-17-one.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B20 (EC:2.4.1.17)
Short name:
UDPGT 2B20
Gene namesi
Name:UGT2B20
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei495 – 51521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 530507UDP-glucuronosyltransferase 2B20
PRO_0000036044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi316 – 3161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi483 – 4831N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiO77649.

Structurei

3D structure databases

ProteinModelPortaliO77649.
SMRiO77649. Positions 286-447.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004033.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77649-1 [UniParc]FASTAAdd to Basket

« Hide

MSLKWTSVFL LLQLSCYFSS GSCGKVLVWP TEYSHWINMK TILEELVRRR    50
HEVTVLTSSA STFVNDSKSS AIKFEVYPTS LTKNDMEDSL MKLLDIWTYS 100
ISNSTFLSYF SKLQELCWEY YYYSEKLCKD AVLNKKLMTK LKETKFDVIL 150
ADALNPCGEL LAELFNIPFV YSLRFTVGYT FEKNGGGFLF PPSYVPVVMS 200
ELSDQMTFTE RIKNMIHKLY FDFWFQIHDI KKWDQFYSEV LGRPTTLFET 250
MRKAEMWLIR TYWDFEFPRP FLPNVDFVGG LHCKPAKPLP KEMEEFVQSS 300
GENGVVVFSL GSMISNMSEE RANMIASALA QIPQKVLWKF DGKKPNTLGS 350
NTRLYKWLPQ NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ 400
HDNIVHMKVK GAALSVDIRT MSSRDLLNAL KSVINEPIYK ENAMKLSRIH 450
HDQPMKPLDR AVFWIEFVMR HKGAKHLRVA AHNLTWIQYH SLDVIAFLLA 500
CVAAVIFIIT KCCLFCFRKL AKTGKKKKWD 530
Length:530
Mass (Da):61,225
Last modified:November 1, 1998 - v1
Checksum:iA5EB47F8D517D8DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF072223 mRNA. Translation: AAD08808.1.
RefSeqiNP_001271878.1. NM_001284949.1.
UniGeneiMfa.4747.

Genome annotation databases

GeneIDi102128580.
KEGGimcf:102128580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF072223 mRNA. Translation: AAD08808.1 .
RefSeqi NP_001271878.1. NM_001284949.1.
UniGenei Mfa.4747.

3D structure databases

ProteinModelPortali O77649.
SMRi O77649. Positions 286-447.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEi O77649.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 102128580.
KEGGi mcf:102128580.

Organism-specific databases

CTDi 102128580.

Phylogenomic databases

HOVERGENi HBG004033.
KOi K00699.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of a simian UDP-glucuronosyltransferase enzyme UGT2B20, a novel C19 steroid-conjugating protein."
    Barbier O., Belanger A., Hum D.W.
    Biochem. J. 337:567-574(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: Liver and Prostate.

Entry informationi

Entry nameiUDB20_MACFA
AccessioniPrimary (citable) accession number: O77649
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi