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Protein

UDP-glucuronosyltransferase 2B20

Gene

UGT2B20

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with androgens, such as testosterone, dihydrotestosterone (DHT) and 3-alpha-diol. It is also active on catecholoestrogens including 1,3,5,10-oestratriene-3,4-diol-17-one.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B20 (EC:2.4.1.17)
Short name:
UDPGT 2B20
Gene namesi
Name:UGT2B20
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei495 – 51521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 530507UDP-glucuronosyltransferase 2B20PRO_0000036044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi483 – 4831N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiO77649.

Structurei

3D structure databases

ProteinModelPortaliO77649.
SMRiO77649. Positions 286-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004033.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKWTSVFL LLQLSCYFSS GSCGKVLVWP TEYSHWINMK TILEELVRRR
60 70 80 90 100
HEVTVLTSSA STFVNDSKSS AIKFEVYPTS LTKNDMEDSL MKLLDIWTYS
110 120 130 140 150
ISNSTFLSYF SKLQELCWEY YYYSEKLCKD AVLNKKLMTK LKETKFDVIL
160 170 180 190 200
ADALNPCGEL LAELFNIPFV YSLRFTVGYT FEKNGGGFLF PPSYVPVVMS
210 220 230 240 250
ELSDQMTFTE RIKNMIHKLY FDFWFQIHDI KKWDQFYSEV LGRPTTLFET
260 270 280 290 300
MRKAEMWLIR TYWDFEFPRP FLPNVDFVGG LHCKPAKPLP KEMEEFVQSS
310 320 330 340 350
GENGVVVFSL GSMISNMSEE RANMIASALA QIPQKVLWKF DGKKPNTLGS
360 370 380 390 400
NTRLYKWLPQ NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ
410 420 430 440 450
HDNIVHMKVK GAALSVDIRT MSSRDLLNAL KSVINEPIYK ENAMKLSRIH
460 470 480 490 500
HDQPMKPLDR AVFWIEFVMR HKGAKHLRVA AHNLTWIQYH SLDVIAFLLA
510 520 530
CVAAVIFIIT KCCLFCFRKL AKTGKKKKWD
Length:530
Mass (Da):61,225
Last modified:November 1, 1998 - v1
Checksum:iA5EB47F8D517D8DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072223 mRNA. Translation: AAD08808.1.
RefSeqiNP_001271878.1. NM_001284949.1.
UniGeneiMfa.4747.

Genome annotation databases

GeneIDi102128580.
KEGGimcf:102128580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072223 mRNA. Translation: AAD08808.1.
RefSeqiNP_001271878.1. NM_001284949.1.
UniGeneiMfa.4747.

3D structure databases

ProteinModelPortaliO77649.
SMRiO77649. Positions 286-447.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEiO77649.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102128580.
KEGGimcf:102128580.

Organism-specific databases

CTDi102128580.

Phylogenomic databases

HOVERGENiHBG004033.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of a simian UDP-glucuronosyltransferase enzyme UGT2B20, a novel C19 steroid-conjugating protein."
    Barbier O., Belanger A., Hum D.W.
    Biochem. J. 337:567-574(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: Liver and Prostate.

Entry informationi

Entry nameiUDB20_MACFA
AccessioniPrimary (citable) accession number: O77649
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: January 7, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.