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Reviewed, UniProtKB/Swiss-Prot O77649 (UDB20_MACFA)

Last modified June 16, 2009. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    UDP-glucuronosyltransferase 2B20
      Short name=UDPGT 2B20
    EC=2.4.1.17
Gene names
Name: UGT2B20
OrganismMacaca fascicularis (Crab eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

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Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with androgens, such as testosterone, dihydrotestosterone (DHT) and 3-alpha-diol. It is also active on catecholoestrogens including 1,3,5,10-oestratriene-3,4-diol-17-one.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

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Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   DomainSignal
Transmembrane
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processmetabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

microsome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucuronosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 530507UDP-glucuronosyltransferase 2B20
PRO_0000036044

Regions

Transmembrane495 – 51521 Potential

Amino acid modifications

Glycosylation651N-linked (GlcNAc...) Potential
Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation3161N-linked (GlcNAc...) Potential
Glycosylation4831N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
O77649-1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: A5EB47F8D517D8DA

FASTA53061,225
        10         20         30         40         50         60 
MSLKWTSVFL LLQLSCYFSS GSCGKVLVWP TEYSHWINMK TILEELVRRR HEVTVLTSSA 

        70         80         90        100        110        120 
STFVNDSKSS AIKFEVYPTS LTKNDMEDSL MKLLDIWTYS ISNSTFLSYF SKLQELCWEY 

       130        140        150        160        170        180 
YYYSEKLCKD AVLNKKLMTK LKETKFDVIL ADALNPCGEL LAELFNIPFV YSLRFTVGYT 

       190        200        210        220        230        240 
FEKNGGGFLF PPSYVPVVMS ELSDQMTFTE RIKNMIHKLY FDFWFQIHDI KKWDQFYSEV 

       250        260        270        280        290        300 
LGRPTTLFET MRKAEMWLIR TYWDFEFPRP FLPNVDFVGG LHCKPAKPLP KEMEEFVQSS 

       310        320        330        340        350        360 
GENGVVVFSL GSMISNMSEE RANMIASALA QIPQKVLWKF DGKKPNTLGS NTRLYKWLPQ 

       370        380        390        400        410        420 
NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ HDNIVHMKVK GAALSVDIRT 

       430        440        450        460        470        480 
MSSRDLLNAL KSVINEPIYK ENAMKLSRIH HDQPMKPLDR AVFWIEFVMR HKGAKHLRVA 

       490        500        510        520        530 
AHNLTWIQYH SLDVIAFLLA CVAAVIFIIT KCCLFCFRKL AKTGKKKKWD

« Hide

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References

[1]"Cloning and characterization of a simian UDP-glucuronosyltransferase enzyme UGT2B20, a novel C19 steroid-conjugating protein."
Barbier O., Belanger A., Hum D.W.
Biochem. J. 337:567-574(1999) [PubMed: 9895303] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Tissue: Liver and Prostate.

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Cross-references

Sequence databases

AF072223 mRNA. Translation: AAD08808.1.

3D structure databases

SMRO77649. Positions 286-447.
ModBaseSearch...

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Phylogenomic databases

HOVERGENO77649.

Enzyme and pathway databases

BRENDA2.4.1.17. 3438.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. UDP_glucos_trans. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameUDB20_MACFA
AccessionPrimary (citable) accession number: O77649
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: June 16, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents