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Protein

T-complex protein 1 subunit zeta

Gene

CCT6

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit zeta
Short name:
TCP-1-zeta
Alternative name(s):
CCT-zeta
Gene namesi
Name:CCT6
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 531530T-complex protein 1 subunit zetaPRO_0000128359Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei5 – 51N6-acetyllysineBy similarity
Modified residuei199 – 1991N6-acetyllysineBy similarity
Modified residuei205 – 2051PhosphoserineBy similarity
Modified residuei287 – 2871N6-acetyllysineBy similarity
Modified residuei365 – 3651N6-acetyllysineBy similarity
Modified residuei377 – 3771N6-acetyllysineBy similarity
Modified residuei388 – 3881N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiO77622.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
WRAP53Q9BUR42EBI-10714431,EBI-2563542From a different organism.

Protein-protein interaction databases

IntActiO77622. 1 interaction.
STRINGi9986.ENSOCUP00000015180.

Structurei

3D structure databases

ProteinModelPortaliO77622.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0359. Eukaryota.
ENOG410XQ3Q. LUCA.
GeneTreeiENSGT00550000074743.
HOGENOMiHOG000226733.
HOVERGENiHBG103725.
InParanoidiO77622.
KOiK09498.
OMAiEPMKPVD.
OrthoDBiEOG091G07CE.
TreeFamiTF106333.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVKTLNPK AEVARAQAAL AVNISAARGL QDVLRTNLGP KGTMKMLVSG
60 70 80 90 100
AGDIKLTKDG NVLLHEMQIQ HPTASLIAKV ATAQDDITGD GTTSNVLIIG
110 120 130 140 150
ELLKQADLYI SEGLHPRIIT EGFEAAKEKA LQVLEQIKVS REMDRETLID
160 170 180 190 200
VARTSLRTKV HAELADVLTE AVVDSILAIK KQDEPIDLFM VEIMEMKHKS
210 220 230 240 250
ETDTSLIRGL VLDHGARHPD MKKRVEDAYI LTCNVSLEYE KTEVNSGFFY
260 270 280 290 300
KSAEEREKLV KAERKFIEDR VKKIVELKKK VCGDSDKGFV VINQKGIDPF
310 320 330 340 350
SLDALAKEGI VALRRAKRRN MERLTLACGG VPLNSLDDLN PDCLGHAGLV
360 370 380 390 400
YEYTLGEEKF TFIEKCNNPR SVTLLVKGPN KHTLTQIKDA IRDGLRAVKN
410 420 430 440 450
AIDDGCVVPG AGAVEVAMAE ALIKYKSSVK GRAQLGVQAF ADALLIIPKV
460 470 480 490 500
LAQNSGFDLQ ETLVKIRTEH SESGQLVGVD LNTGEPMVAA EVGIWDNYCV
510 520 530
KKQLLHSCTV IATNILLVDE IMRAGMSSLK G
Length:531
Mass (Da):58,024
Last modified:January 23, 2007 - v3
Checksum:i2A5007DA986A5338
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068483 mRNA. Translation: AAC19379.1.
RefSeqiNP_001075508.1. NM_001082039.1.
UniGeneiOcu.2206.

Genome annotation databases

EnsembliENSOCUT00000017675; ENSOCUP00000015180; ENSOCUG00000017674.
GeneIDi100008688.
KEGGiocu:100008688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068483 mRNA. Translation: AAC19379.1.
RefSeqiNP_001075508.1. NM_001082039.1.
UniGeneiOcu.2206.

3D structure databases

ProteinModelPortaliO77622.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO77622. 1 interaction.
STRINGi9986.ENSOCUP00000015180.

Proteomic databases

PRIDEiO77622.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000017675; ENSOCUP00000015180; ENSOCUG00000017674.
GeneIDi100008688.
KEGGiocu:100008688.

Organism-specific databases

CTDi908.

Phylogenomic databases

eggNOGiKOG0359. Eukaryota.
ENOG410XQ3Q. LUCA.
GeneTreeiENSGT00550000074743.
HOGENOMiHOG000226733.
HOVERGENiHBG103725.
InParanoidiO77622.
KOiK09498.
OMAiEPMKPVD.
OrthoDBiEOG091G07CE.
TreeFamiTF106333.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCPZ_RABIT
AccessioniPrimary (citable) accession number: O77622
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.