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Protein

Melanocyte-stimulating hormone receptor

Gene

MC1R

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Could be involved in spermatogenesis.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocyte-stimulating hormone receptor
Short name:
MSH-R
Alternative name(s):
Melanocortin receptor 1
Short name:
MC1-R
Gene namesi
Name:MC1R
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737ExtracellularSequence analysisAdd
BLAST
Transmembranei38 – 6326Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini64 – 729CytoplasmicSequence analysis
Transmembranei73 – 9321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini94 – 11825ExtracellularSequence analysisAdd
BLAST
Transmembranei119 – 14022Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini141 – 16323CytoplasmicSequence analysisAdd
BLAST
Transmembranei164 – 18320Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini184 – 1918ExtracellularSequence analysis
Transmembranei192 – 21120Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini212 – 24029CytoplasmicSequence analysisAdd
BLAST
Transmembranei241 – 26626Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini267 – 27913ExtracellularSequence analysisAdd
BLAST
Transmembranei280 – 30021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini301 – 31717CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Melanocyte-stimulating hormone receptorPRO_0000069798Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence analysis
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Lipidationi315 – 3151S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Interactioni

Subunit structurei

Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production.By similarity

Structurei

3D structure databases

ProteinModelPortaliO77616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiO77616.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
IPR000761. MSH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF2. PTHR22750:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00536. MELNOCYTESHR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O77616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWQGPQRRL LGSLNGTSPA TPHFELAANQ TGPRCLEVSI PNGLFLSLGL
60 70 80 90 100
VSVVENVLVV AAIAKNRNLH SPMYYFIGCL AVSDLLVSVT NVLETAVMLL
110 120 130 140 150
VEAGALAAQA AVVQQLDDII DVLICGSMVS SLCFLGAIAV DRYLSIFYAL
160 170 180 190 200
RYHSIVTLPR AWRAISAIWV ASVLSSTLFI AYYNHTAVLL CLVSFFVAML
210 220 230 240 250
VLMAVLYVHM LARARQHARG IARLRKRQHS VHQGFGLKGA ATLTILLGIF
260 270 280 290 300
FLCWGPFFLH LSLMVLCPQH PICGCVFQNF NLFLTLIICN SIIDPFIYAF
310
RSQELRKTLQ EVVLCSW
Length:317
Mass (Da):34,984
Last modified:May 1, 2000 - v2
Checksum:iF10FDD9552BEF922
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti306 – 31712Missing in Labrador and Golden retriever with yellow coat color. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064455 Genomic DNA. Translation: AAC33737.2.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064455 Genomic DNA. Translation: AAC33737.2.

3D structure databases

ProteinModelPortaliO77616.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiO77616.

Miscellaneous databases

NextBioi20862804.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
IPR000761. MSH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF2. PTHR22750:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00536. MELNOCYTESHR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of a premature stop codon in the melanocyte-stimulating hormone receptor gene (MC1R) in Labrador and Golden retrievers with yellow coat colour."
    Everts R.E., Rothuizen J., van Oost B.A.
    Anim. Genet. 31:194-199(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT 306-ARG--TRP-317 DEL.

Entry informationi

Entry nameiMSHR_CANLF
AccessioniPrimary (citable) accession number: O77616
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.