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Protein

Melanocyte-stimulating hormone receptor

Gene

MC1R

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Could be involved in spermatogenesis.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocyte-stimulating hormone receptor
Short name:
MSH-R
Alternative name(s):
Melanocortin receptor 1
Short name:
MC1-R
Gene namesi
Name:MC1R
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularSequence analysisAdd BLAST37
Transmembranei38 – 63Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini64 – 72CytoplasmicSequence analysis9
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 118ExtracellularSequence analysisAdd BLAST25
Transmembranei119 – 140Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini141 – 163CytoplasmicSequence analysisAdd BLAST23
Transmembranei164 – 183Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini184 – 191ExtracellularSequence analysis8
Transmembranei192 – 211Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini212 – 240CytoplasmicSequence analysisAdd BLAST29
Transmembranei241 – 266Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini267 – 279ExtracellularSequence analysisAdd BLAST13
Transmembranei280 – 300Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini301 – 317CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697981 – 317Melanocyte-stimulating hormone receptorAdd BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi315S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Interactioni

Subunit structurei

Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production.By similarity

Structurei

3D structure databases

ProteinModelPortaliO77616
SMRiO77616
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000246927
HOVERGENiHBG108148
InParanoidiO77616

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001671 Melcrt_ACTH_rcpt
IPR000761 MSH_rcpt
PANTHERiPTHR22750:SF2 PTHR22750:SF2, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00534 MCRFAMILY
PR00536 MELNOCYTESHR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O77616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWQGPQRRL LGSLNGTSPA TPHFELAANQ TGPRCLEVSI PNGLFLSLGL
60 70 80 90 100
VSVVENVLVV AAIAKNRNLH SPMYYFIGCL AVSDLLVSVT NVLETAVMLL
110 120 130 140 150
VEAGALAAQA AVVQQLDDII DVLICGSMVS SLCFLGAIAV DRYLSIFYAL
160 170 180 190 200
RYHSIVTLPR AWRAISAIWV ASVLSSTLFI AYYNHTAVLL CLVSFFVAML
210 220 230 240 250
VLMAVLYVHM LARARQHARG IARLRKRQHS VHQGFGLKGA ATLTILLGIF
260 270 280 290 300
FLCWGPFFLH LSLMVLCPQH PICGCVFQNF NLFLTLIICN SIIDPFIYAF
310
RSQELRKTLQ EVVLCSW
Length:317
Mass (Da):34,984
Last modified:May 1, 2000 - v2
Checksum:iF10FDD9552BEF922
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti306 – 317Missing in Labrador and Golden retriever with yellow coat color. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064455 Genomic DNA Translation: AAC33737.2

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMSHR_CANLF
AccessioniPrimary (citable) accession number: O77616
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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