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Protein

Phosducin

Gene

PDC

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism.By similarity

GO - Biological processi

Keywordsi

Biological processSensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin
Short name:
PHD
Alternative name(s):
33 kDa phototransducing protein
Gene namesi
Name:PDC
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in PDC are the cause of photoreceptor dysplasia (PD); an autosomal recessive disease of miniature schnauzer dogs causing retinal degeneration.1 Publication

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001637491 – 245PhosducinAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73Phosphoserine; by PKABy similarity1

Post-translational modificationi

Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO77560.

Expressioni

Gene expression databases

BgeeiENSCAFG00000013751.

Interactioni

Subunit structurei

Interacts with CRX (By similarity). Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000035560.

Structurei

3D structure databases

ProteinModelPortaliO77560.
SMRiO77560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 245Thioredoxin foldBy similarityAdd BLAST135

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3171. Eukaryota.
ENOG4110DRD. LUCA.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000232010.
HOVERGENiHBG003456.
InParanoidiO77560.
KOiK08327.
OMAiCMQDMHQ.
OrthoDBiEOG091G0ISM.
TreeFamiTF315179.

Family and domain databases

CDDicd02987. Phd_like_Phd. 1 hit.
Gene3Di1.10.168.10. 2 hits.
InterProiView protein in InterPro
IPR001200. Phosducin.
IPR023196. Phosducin_N_dom_sf.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR036249. Thioredoxin-like_sf.
PfamiView protein in Pfam
PF02114. Phosducin. 1 hit.
PRINTSiPR00677. PHOSDUCIN.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

O77560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEAKNQSLE EDFEGQATHT GPKGVINDWR KFKLESEDSD SVPPSKKEIL
60 70 80 90 100
RQMSSPQNRD DKDSKERFSR KMSIQEYELI HRDKEDENCL RKYRRQCMQD
110 120 130 140 150
MHQKLSFGPR YGFVYELETG EQFLETIEKE QKITTIVVHI YEDGVKGCDA
160 170 180 190 200
LNSSFTCLAA EYPMVKFCKI KASNTGAGDR FSSDVLPTLL IYKGGELISN
210 220 230 240
FISVTEQFAE EFFAGDVESF LNEYGLLPER EIHALDQTNM EEDTE
Length:245
Mass (Da):28,306
Last modified:April 26, 2005 - v2
Checksum:iD201EF3A6E7DD232
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198I → L in AAC27249 (PubMed:9714819).Curated1
Sequence conflicti204V → G in AAC27249 (PubMed:9714819).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti82R → G in PD. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046874 mRNA. Translation: AAC27249.1.
Y17697 mRNA. Translation: CAA76818.1.
AJ417559, AJ417560, AJ417561 Genomic DNA. Translation: CAD10383.2.
RefSeqiNP_001003076.1. NM_001003076.1.
UniGeneiCfa.1202.

Genome annotation databases

EnsembliENSCAFT00000021818; ENSCAFP00000020267; ENSCAFG00000013751.
ENSCAFT00000039677; ENSCAFP00000035560; ENSCAFG00000013751.
GeneIDi403624.
KEGGicfa:403624.

Similar proteinsi

Entry informationi

Entry nameiPHOS_CANLF
AccessioniPrimary (citable) accession number: O77560
Secondary accession number(s): Q9TSE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 26, 2005
Last modified: November 22, 2017
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families