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Protein

Phosducin

Gene

PDC

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin
Short name:
PHD
Alternative name(s):
33 kDa phototransducing protein
Gene namesi
Name:PDC
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 7

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Nucleus By similarity
  • Cell projectionciliumphotoreceptor outer segment By similarity
  • Photoreceptor inner segment By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in PDC are the cause of photoreceptor dysplasia (PD); an autosomal recessive disease of miniature schnauzer dogs causing retinal degeneration.

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001637491 – 245PhosducinAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73Phosphoserine; by PKABy similarity1

Post-translational modificationi

Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO77560.

Interactioni

Subunit structurei

Interacts with CRX (By similarity). Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000035560.

Structurei

3D structure databases

ProteinModelPortaliO77560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 245Thioredoxin foldBy similarityAdd BLAST135

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3171. Eukaryota.
ENOG4110DRD. LUCA.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000232010.
HOVERGENiHBG003456.
InParanoidiO77560.
KOiK08327.
OMAiCMQDMHQ.
OrthoDBiEOG091G0ISM.
TreeFamiTF315179.

Family and domain databases

Gene3Di1.10.168.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR001200. Phosducin.
IPR023196. Phosducin_N_dom.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
PRINTSiPR00677. PHOSDUCIN.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

O77560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEAKNQSLE EDFEGQATHT GPKGVINDWR KFKLESEDSD SVPPSKKEIL
60 70 80 90 100
RQMSSPQNRD DKDSKERFSR KMSIQEYELI HRDKEDENCL RKYRRQCMQD
110 120 130 140 150
MHQKLSFGPR YGFVYELETG EQFLETIEKE QKITTIVVHI YEDGVKGCDA
160 170 180 190 200
LNSSFTCLAA EYPMVKFCKI KASNTGAGDR FSSDVLPTLL IYKGGELISN
210 220 230 240
FISVTEQFAE EFFAGDVESF LNEYGLLPER EIHALDQTNM EEDTE
Length:245
Mass (Da):28,306
Last modified:April 26, 2005 - v2
Checksum:iD201EF3A6E7DD232
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198I → L in AAC27249 (PubMed:9714819).Curated1
Sequence conflicti204V → G in AAC27249 (PubMed:9714819).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti82R → G in PD. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046874 mRNA. Translation: AAC27249.1.
Y17697 mRNA. Translation: CAA76818.1.
AJ417559, AJ417560, AJ417561 Genomic DNA. Translation: CAD10383.2.
RefSeqiNP_001003076.1. NM_001003076.1.
UniGeneiCfa.1202.

Genome annotation databases

EnsembliENSCAFT00000021818; ENSCAFP00000020267; ENSCAFG00000013751.
ENSCAFT00000039677; ENSCAFP00000035560; ENSCAFG00000013751.
GeneIDi403624.
KEGGicfa:403624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046874 mRNA. Translation: AAC27249.1.
Y17697 mRNA. Translation: CAA76818.1.
AJ417559, AJ417560, AJ417561 Genomic DNA. Translation: CAD10383.2.
RefSeqiNP_001003076.1. NM_001003076.1.
UniGeneiCfa.1202.

3D structure databases

ProteinModelPortaliO77560.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000035560.

Proteomic databases

PaxDbiO77560.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000021818; ENSCAFP00000020267; ENSCAFG00000013751.
ENSCAFT00000039677; ENSCAFP00000035560; ENSCAFG00000013751.
GeneIDi403624.
KEGGicfa:403624.

Organism-specific databases

CTDi5132.

Phylogenomic databases

eggNOGiKOG3171. Eukaryota.
ENOG4110DRD. LUCA.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000232010.
HOVERGENiHBG003456.
InParanoidiO77560.
KOiK08327.
OMAiCMQDMHQ.
OrthoDBiEOG091G0ISM.
TreeFamiTF315179.

Family and domain databases

Gene3Di1.10.168.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR001200. Phosducin.
IPR023196. Phosducin_N_dom.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
PRINTSiPR00677. PHOSDUCIN.
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHOS_CANLF
AccessioniPrimary (citable) accession number: O77560
Secondary accession number(s): Q9TSE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 26, 2005
Last modified: October 5, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.