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Protein

ADM

Gene

ADM

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

AM and PAMP are potent hypotensive and vasodilatator agents.

GO - Molecular functioni

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
ADM
Cleaved into the following 2 chains:
Adrenomedullin
Short name:
AM
Alternative name(s):
ProAM N-terminal 20 peptide
Short name:
PAMP
Short name:
ProAM-N20
Gene namesi
Name:ADM
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
PeptideiPRO_000000095722 – 41Proadrenomedullin N-20 terminal peptideBy similarityAdd BLAST20
PropeptideiPRO_000000095845 – 92By similarityAdd BLAST48
PeptideiPRO_000000095995 – 146AdrenomedullinBy similarityAdd BLAST52
PropeptideiPRO_0000000960153 – 188PreproAM C-terminal fragmentBy similarityAdd BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41Arginine amideBy similarity1
Disulfide bondi110 ↔ 115By similarity
Modified residuei146Tyrosine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiO77559

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000011183

Structurei

3D structure databases

SMRiO77559
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adrenomedullin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IK4C Eukaryota
ENOG41120TV LUCA
HOGENOMiHOG000033821
HOVERGENiHBG004181
InParanoidiO77559
KOiK12333
TreeFamiTF333447

Family and domain databases

InterProiView protein in InterPro
IPR001710 Adrenomedullin
IPR021116 Calcitonin/adrenomedullin
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSiPR00801 ADRENOMEDULN

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77559-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVPVALLY LGSLAFLGAD TARLDVASEF RKKWNKWAVS RGKRELRVSS
60 70 80 90 100
SYPTGLAEVK AGPAQTLIRT QDVKGASRNP QTSGPDAARI RVKRYRQSMN
110 120 130 140 150
NFQGPRSFGC RFGTCTVQKL AHQIYQFTDN DKDGVAPRSK ISPQGYGRRR
160 170 180
RRSLPEPGLR RTLLFPEPRP GGAPAPRAHQ VLANLLKM
Length:188
Mass (Da):20,929
Last modified:May 1, 1999 - v2
Checksum:i809D6A64F98F5578
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130N → K in AAD09957 (PubMed:9788655).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045773 mRNA Translation: AAD05423.1
U96127 mRNA Translation: AAD09957.1
AB191461 mRNA Translation: BAD52304.1
RefSeqiNP_001003183.1, NM_001003183.1
UniGeneiCfa.3681

Genome annotation databases

GeneIDi403817
KEGGicfa:403817

Similar proteinsi

Entry informationi

Entry nameiADML_CANLF
AccessioniPrimary (citable) accession number: O77559
Secondary accession number(s): Q9TVC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: May 10, 2017
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health