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Protein

CD59 glycoprotein

Gene

CD59

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
CD59 glycoprotein
Alternative name(s):
MAC-inhibitory protein
Short name:
MAC-IP
Membrane attack complex inhibition factor
Short name:
MACIF
Protectin
CD_antigen: CD59
Gene namesi
Name:CD59
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000003612225 – 101CD59 glycoproteinAdd BLAST77
PropeptideiPRO_0000036123102 – 124Removed in mature formBy similarityAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 51By similarity
Disulfide bondi31 ↔ 38By similarity
Glycosylationi37N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi44 ↔ 64By similarity
Disulfide bondi70 ↔ 88By similarity
Disulfide bondi89 ↔ 94By similarity
Lipidationi101GPI-anchor amidated glycineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000016507.

Structurei

3D structure databases

ProteinModelPortaliO77541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 101UPAR/Ly6Add BLAST77

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J39P. Eukaryota.
ENOG410ZEQP. LUCA.
HOGENOMiHOG000232180.
HOVERGENiHBG005284.
InParanoidiO77541.
KOiK04008.

Family and domain databases

InterProiView protein in InterPro
IPR027101. CD59_glyco.
IPR016054. LY6_UPA_recep-like.
PANTHERiPTHR10036:SF13. PTHR10036:SF13. 1 hit.
PfamiView protein in Pfam
PF00021. UPAR_LY6. 1 hit.
SMARTiView protein in SMART
SM00134. LU. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRGVHLLL RLLFLLAVFY SSDSSLMCYH CLLPSPNCST VTNCTPNHDA
60 70 80 90 100
CLTAVSGPRV YRQCWRYEDC NFEFISNRLE ENSLKYNCCR KDLCNGPEDD
110 120
GTALTGRTVL LVAPLLAAAR NLCL
Length:124
Mass (Da):13,870
Last modified:November 1, 1998 - v1
Checksum:iCEA64C816772CABD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040387 mRNA. Translation: AAC23590.1.
RefSeqiNP_001076181.1. NM_001082712.1.
UniGeneiOcu.3675.

Genome annotation databases

GeneIDi100009459.
KEGGiocu:100009459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040387 mRNA. Translation: AAC23590.1.
RefSeqiNP_001076181.1. NM_001082712.1.
UniGeneiOcu.3675.

3D structure databases

ProteinModelPortaliO77541.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000016507.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009459.
KEGGiocu:100009459.

Organism-specific databases

CTDi966.

Phylogenomic databases

eggNOGiENOG410J39P. Eukaryota.
ENOG410ZEQP. LUCA.
HOGENOMiHOG000232180.
HOVERGENiHBG005284.
InParanoidiO77541.
KOiK04008.

Family and domain databases

InterProiView protein in InterPro
IPR027101. CD59_glyco.
IPR016054. LY6_UPA_recep-like.
PANTHERiPTHR10036:SF13. PTHR10036:SF13. 1 hit.
PfamiView protein in Pfam
PF00021. UPAR_LY6. 1 hit.
SMARTiView protein in SMART
SM00134. LU. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCD59_RABIT
AccessioniPrimary (citable) accession number: O77541
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: February 15, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The mature form of this CD59 contains an additional serine residue before the conserved N-terminal leucine residue found in all other CD59 homologs sequenced to date.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.