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Protein

CD59 glycoprotein

Gene

CD59

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CD59 glycoprotein
Alternative name(s):
MAC-inhibitory protein
Short name:
MAC-IP
Membrane attack complex inhibition factor
Short name:
MACIF
Protectin
CD_antigen: CD59
Gene namesi
Name:CD59
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000003612225 – 101CD59 glycoproteinAdd BLAST77
PropeptideiPRO_0000036123102 – 124Removed in mature formBy similarityAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 51By similarity
Disulfide bondi31 ↔ 38By similarity
Glycosylationi37N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi44 ↔ 64By similarity
Disulfide bondi70 ↔ 88By similarity
Disulfide bondi89 ↔ 94By similarity
Lipidationi101GPI-anchor amidated glycineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000016507.

Structurei

3D structure databases

ProteinModelPortaliO77541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 101UPAR/Ly6Add BLAST77

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J39P. Eukaryota.
ENOG410ZEQP. LUCA.
HOGENOMiHOG000232180.
HOVERGENiHBG005284.
InParanoidiO77541.
KOiK04008.

Family and domain databases

InterProiIPR027101. CD59_glyco.
IPR016054. LY6_UPA_recep-like.
[Graphical view]
PANTHERiPTHR10036:SF9. PTHR10036:SF9. 1 hit.
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
SMARTiSM00134. LU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRGVHLLL RLLFLLAVFY SSDSSLMCYH CLLPSPNCST VTNCTPNHDA
60 70 80 90 100
CLTAVSGPRV YRQCWRYEDC NFEFISNRLE ENSLKYNCCR KDLCNGPEDD
110 120
GTALTGRTVL LVAPLLAAAR NLCL
Length:124
Mass (Da):13,870
Last modified:November 1, 1998 - v1
Checksum:iCEA64C816772CABD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040387 mRNA. Translation: AAC23590.1.
RefSeqiNP_001076181.1. NM_001082712.1.
UniGeneiOcu.3675.

Genome annotation databases

GeneIDi100009459.
KEGGiocu:100009459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040387 mRNA. Translation: AAC23590.1.
RefSeqiNP_001076181.1. NM_001082712.1.
UniGeneiOcu.3675.

3D structure databases

ProteinModelPortaliO77541.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000016507.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009459.
KEGGiocu:100009459.

Organism-specific databases

CTDi966.

Phylogenomic databases

eggNOGiENOG410J39P. Eukaryota.
ENOG410ZEQP. LUCA.
HOGENOMiHOG000232180.
HOVERGENiHBG005284.
InParanoidiO77541.
KOiK04008.

Family and domain databases

InterProiIPR027101. CD59_glyco.
IPR016054. LY6_UPA_recep-like.
[Graphical view]
PANTHERiPTHR10036:SF9. PTHR10036:SF9. 1 hit.
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
SMARTiSM00134. LU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD59_RABIT
AccessioniPrimary (citable) accession number: O77541
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The mature form of this CD59 contains an additional serine residue before the conserved N-terminal leucine residue found in all other CD59 homologs sequenced to date.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.