Reviewed, UniProtKB/Swiss-Prot O77486 (FUT2_GORGO)

Names and origin

Protein names

Recommended name:
    Galactoside 2-alpha-L-fucosyltransferase 2
    EC=2.4.1.69
Alternative name(s):
    GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
    Alpha(1,2)FT 2
    Fucosyltransferase 2

Gene names

Name:

FUT2

Organism

Gorilla gorilla gorilla (Lowland gorilla)

Taxonomic identifier

9595 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Gorilla

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity.
Sequence similarities	Belongs to the glycosyltransferase 11 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	galactoside 2-alpha-L-fucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Galactoside 2-alpha-L-fucosyltransferase 2		PRO_0000149107
Regions
	Topological domain	1 – 14	14	Cytoplasmic Potential
	Transmembrane	15 – 28	14	Signal-anchor for type II membrane protein Potential
	Topological domain	29 – 343	315	Lumenal Potential
Amino acid modifications
	Glycosylation	188	1	N-linked (GlcNAc...) Potential
	Glycosylation	282	1	N-linked (GlcNAc...) Potential
	Glycosylation	308	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	191	1	Q → R in AAF14068. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O77486-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 894E28BD74AE8FBC	FASTA	343	38,973
	10 20 30 40 50 60 MLVVQMPFSF PMAHFILFVF TVSTIFHVQQ RLAKIQAMWE LPVQIPVLAS TSKALGPSQL 70 80 90 100 110 120 RGMWTINAIG RLGNQMGEYA TLYALAKMNG RPAFIPAQMH STLAPIFRIT LPVLHSATAS 130 140 150 160 170 180 RIPWQNYHLN DWMEEEYRHI PGEYVRFTGY PCSWTFYHHL RQEILQEFTL HDHVREEAQK 190 200 210 220 230 240 FLRGLQVNGS QPGTFVGVHV RRGDYVHVMP KVWKGVVADR RYLQQALDWF RARYSSPIFV 250 260 270 280 290 300 VTSNGMAWCR ENIDTSHGDV VFAGDGIEGS PAKDFALLTQ CNHTIMTIGT FGIWAAYLTG 310 320 330 340 GDTIYLANYT LPDSPFLKIF KPEAAFLPEW TGIAADLSPL LKH

References

[1]	"The old origin of a null allele se428 of the human ABO-secretor type alpha(1,2) fucosyltransferase gene (FUT2)." Koda Y., Tachida H., Soejima M., Takenaka O., Kimura H. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Evolution of alpha 2-fucosyltransferase genes in primates: relation between an intronic Alu-Y element and red cell expression of ABH antigens." Apoil P.-A., Roubinet F., Despiau S., Mollicone R., Oriol R., Blancher A. Mol. Biol. Evol. 17:337-351(2000) [PubMed: 10723735] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Isolate Alexis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB015635 Genomic DNA. Translation: BAA31128.1. AF080606 Genomic DNA. Translation: AAF14068.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT11. Glycosyltransferase Family 11.
Phylogenomic databases
HOVERGEN	O77486.
Enzyme and pathway databases
BRENDA	2.4.1.69. 299462.
Family and domain databases
InterPro	IPR002516. Glyco_trans_11. [Graphical view]
PANTHER	PTHR11927. Glyco_trans_11. 1 hit.
Pfam	PF01531. Glyco_transf_11. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FUT2_GORGO

Accession

Primary (citable) accession number: O77486
Secondary accession number(s): Q9TUD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	November 1, 1998
Last modified:	October 13, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)