Reviewed, UniProtKB/Swiss-Prot O77485 (FUT2_PANTR)

Names and origin

Protein names

Recommended name:
    Galactoside 2-alpha-L-fucosyltransferase 2
    EC=2.4.1.69
Alternative name(s):
    GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
    Alpha(1,2)FT 2
    Fucosyltransferase 2

Gene names

Name:

FUT2

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity.
Sequence similarities	Belongs to the glycosyltransferase 11 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	galactoside 2-alpha-L-fucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Galactoside 2-alpha-L-fucosyltransferase 2		PRO_0000149110
Regions
	Topological domain	1 – 14	14	Cytoplasmic Potential
	Transmembrane	15 – 28	14	Signal-anchor for type II membrane protein Potential
	Topological domain	29 – 343	315	Lumenal Potential
Amino acid modifications
	Glycosylation	188	1	N-linked (GlcNAc...) Potential
	Glycosylation	282	1	N-linked (GlcNAc...) Potential
	Glycosylation	308	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O77485-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: B849D7E152852081	FASTA	343	38,999
	10 20 30 40 50 60 MLVVQMPFSF PVAHFILFVF TVSTIFHVQQ RLAKIQAMWE LPVQIPVLAS TSKALGPSQL 70 80 90 100 110 120 RGMWTINAIG RLGNQMGEYA TLYALAKMNG RPAFIPAQMH STLAPIFRIT LPVLHSATAS 130 140 150 160 170 180 RIPWQNYHLN DWMEEEYRHI PGEYVRFTGY PCSWTFYHHL RQEILQEFTL HDHVREEAQK 190 200 210 220 230 240 FLRGLQVNGS RPGTFVGVHV RRGDYVHVMP KVWKGVVADR RYLQQALDWF RARYSSPIFV 250 260 270 280 290 300 VTSNGMAWCR ENIDTSHGDV VFAGDGIEGS PAKDFALLTQ CNHTIMTIGT FGIWAAYLTG 310 320 330 340 GDTIYLANYT LPDSPFLKIF KPEAAFLPEW MGIAADLSPL LKH

References

[1]	"The old origin of a null allele se428 of the human ABO-secretor type alpha(1,2) fucosyltransferase gene (FUT2)." Koda Y., Tachida H., Soejima M., Takenaka O., Kimura H. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Evolution of alpha 2-fucosyltransferase genes in primates: relation between an intronic Alu-Y element and red cell expression of ABH antigens." Apoil P.-A., Roubinet F., Despiau S., Mollicone R., Oriol R., Blancher A. Mol. Biol. Evol. 17:337-351(2000) [PubMed: 10723735] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Isolate CH16.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB015634 Genomic DNA. Translation: BAA31127.1. AF080604 Genomic DNA. Translation: AAF14066.1. Different initiation.
RefSeq	NP_001009120.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O77485.
Protein family/group databases
CAZy	GT11. Glycosyltransferase Family 11.
Genome annotation databases
Ensembl	ENSPTRT00000047534; ENSPTRP00000046610; ENSPTRG00000011251; Pan troglodytes. [Genome view]
GeneID	468944.
KEGG	ptr:468944.
Phylogenomic databases
HOVERGEN	O77485.
OMA	INAIGRL.
Enzyme and pathway databases
BRENDA	2.4.1.69. 264977.
Family and domain databases
InterPro	IPR002516. Glyco_trans_11. [Graphical view]
PANTHER	PTHR11927. Glyco_trans_11. 1 hit.
Pfam	PF01531. Glyco_transf_11. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FUT2_PANTR

Accession

Primary (citable) accession number: O77485
Secondary accession number(s): Q9TUD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	November 1, 1998
Last modified:	November 3, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)