SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O77473

- GST1B_ANOGA

UniProt

O77473 - GST1B_ANOGA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glutathione S-transferase 1, isoform B
Gene
GstD1, GST1a, AGAP004164
Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 1, isoform B (EC:2.5.1.18)
Alternative name(s):
AgGst1-alpha
Aggst1-4
GST class-theta
Gene namesi
Name:GstD1
Synonyms:GST1a
ORF Names:AGAP004164
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
ProteomesiUP000007062: Chromosome 2R

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Glutathione S-transferase 1, isoform B
PRO_0000283093Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliO77473.
SMRiO77473. Positions 1-211.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8080GST N-terminal
Add
BLAST
Domaini89 – 210122GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 523Glutathione binding By similarity
Regioni64 – 663Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.

Phylogenomic databases

HOGENOMiHOG000125741.
KOiK00799.
OMAiILAYLCE.
OrthoDBiEOG7V1FRJ.
PhylomeDBiO77473.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform B1 Publication (identifier: O77473-1) [UniParc]FASTAAdd to Basket

Also known as: 1-4

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDFYYLPGSA PCRAVQMTAA AVGVELNLKL TDLMKGEHMK PEFLKLNPQH    50
CVPTLVDNGF ALWESRAIMC YLVEKYGKPC NNDSLYPTDP QKRAIVNQRL 100
YFDMGTLYQR FGDYYYPQIF EGAPANETNF AKIGEALAFL DTFLEGERFV 150
AGGNGYSLAD ISLYATLTTF EVAGYDFSAY VNVLRWYKSM PELIPASDTN 200
RSWAEAARPF FDKVKH 216
Length:216
Mass (Da):24,492
Last modified:October 5, 2010 - v2
Checksum:i0E764BDFB98038D1
GO
Isoform A1 Publication (identifier: O77462-1) [UniParc]FASTAAdd to Basket

Also known as: 1-3

The sequence of this isoform can be found in the external entry O77462.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:186
Mass (Da):21,255
GO
Isoform C1 Publication (identifier: Q93112-1) [UniParc]FASTAAdd to Basket

Also known as: 1-5

The sequence of this isoform can be found in the external entry Q93112.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:209
Mass (Da):23,783
GO
Isoform D1 Publication (identifier: Q93113-1) [UniParc]FASTAAdd to Basket

Also known as: 1-1, 1-6, 2-1

The sequence of this isoform can be found in the external entry Q93113.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:209
Mass (Da):23,445
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581N → S in AAC79994. 1 Publication
Sequence conflicti58 – 581N → S in AAC79998. 1 Publication
Sequence conflicti128 – 1281T → A in AAC79994. 1 Publication
Sequence conflicti128 – 1281T → A in AAC79998. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071160 Genomic DNA. Translation: AAC79994.1.
AF071162 mRNA. Translation: AAC79998.1.
AAAB01008880 Genomic DNA. Translation: EAA44711.1.
RefSeqiXP_313048.1. XM_313048.4.

Genome annotation databases

EnsemblMetazoaiAGAP004164-RC; AGAP004164-PC; AGAP004164. [O77473-1]
GeneIDi1273988.
KEGGiaga:AgaP_AGAP004164.
VectorBaseiAGAP004163. Anopheles gambiae.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071160 Genomic DNA. Translation: AAC79994.1 .
AF071162 mRNA. Translation: AAC79998.1 .
AAAB01008880 Genomic DNA. Translation: EAA44711.1 .
RefSeqi XP_313048.1. XM_313048.4.

3D structure databases

ProteinModelPortali O77473.
SMRi O77473. Positions 1-211.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai AGAP004164-RC ; AGAP004164-PC ; AGAP004164 . [O77473-1 ]
GeneIDi 1273988.
KEGGi aga:AgaP_AGAP004164.
VectorBasei AGAP004163. Anopheles gambiae.

Organism-specific databases

CTDi 1273988.

Phylogenomic databases

HOGENOMi HOG000125741.
KOi K00799.
OMAi ILAYLCE.
OrthoDBi EOG7V1FRJ.
PhylomeDBi O77473.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The role of alternative mRNA splicing in generating heterogeneity within the Anopheles gambiae class I glutathione S-transferase family."
    Ranson H., Collins F.H., Hemingway J.
    Proc. Natl. Acad. Sci. U.S.A. 95:14284-14289(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING.
    Strain: ZAN/U.
  2. "The genome sequence of the malaria mosquito Anopheles gambiae."
    Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
    , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
    Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PEST.

Entry informationi

Entry nameiGST1B_ANOGA
AccessioniPrimary (citable) accession number: O77473
Secondary accession number(s): Q7PH26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi