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Protein

Glutathione S-transferase 1, isoform A

Gene

GstD1

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 1, isoform A (EC:2.5.1.18)
Alternative name(s):
AgGst1-alpha
Aggst1-3
GST class-theta
Gene namesi
Name:GstD11 Publication
Synonyms:GST1aImported
ORF Names:AGAP004164
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componentsi: Chromosome 2R, Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002830921 – 186Glutathione S-transferase 1, isoform AAdd BLAST186

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO77462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 81GST N-terminalAdd BLAST81
Domaini92 – 186GST C-terminalAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 52Glutathione bindingBy similarity3
Regioni65 – 67Glutathione bindingBy similarity3

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Sequence analysis
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

HOGENOMiHOG000125741.
OrthoDBiEOG091G0MS3.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A1 Publication (identifier: O77462-1) [UniParc]FASTAAdd to basket
Also known as: 1-31 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFYYLPGSA PCRAVQMTAA AVGVELNLKL TDLMKGEHMK PEFLKLNPQH
60 70 80 90 100
CIPTLVDEDG FVLWESRAIQ IYLVEKYCAH DPALAERLYP GDPRRRAVVH
110 120 130 140 150
QRLFFDVAIL YQRFAEYYYP QIFGKKVAGD PDRLRSMEQA LEFLNTFLEG
160 170 180
ERFVAGGDDP TIADFSILAC ILDCNVRRCR VRSAAI
Length:186
Mass (Da):21,255
Last modified:April 18, 2012 - v3
Checksum:i82B9860A3DD57A81
GO
Isoform B1 Publication (identifier: O77473-1) [UniParc]FASTAAdd to basket
Also known as: 1-41 Publication
The sequence of this isoform can be found in the external entry O77473.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:216
Mass (Da):24,492
GO
Isoform C1 Publication (identifier: Q93112-1) [UniParc]FASTAAdd to basket
Also known as: 1-51 Publication
The sequence of this isoform can be found in the external entry Q93112.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:209
Mass (Da):23,783
GO
Isoform D1 Publication (identifier: Q93113-1) [UniParc]FASTAAdd to basket
Also known as: 1-1, 1-61 Publication, 2-1
The sequence of this isoform can be found in the external entry Q93113.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:209
Mass (Da):23,445
GO

Sequence cautioni

The sequence AAC79992 differs from that shown. Reason: Frameshift at position 172.Curated
The sequence AAC79999 differs from that shown. Reason: Frameshift at position 172.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170 – 171Missing in AAC79992 (PubMed:9826692).Curated2
Sequence conflicti170 – 171Missing in AAC79999 (PubMed:9826692).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071160 Genomic DNA. Translation: AAC79992.1. Frameshift.
AF071163 mRNA. Translation: AAC79999.1. Frameshift.
AAAB01008880 Genomic DNA. Translation: EAL40658.2.
RefSeqiXP_562680.2. XM_562680.2.

Genome annotation databases

EnsemblMetazoaiAGAP004164-RD; AGAP004164-PD; AGAP004164. [O77462-1]
GeneIDi1273988.
VectorBaseiAGAP004164-RD; AGAP004164-PD; AGAP004164.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071160 Genomic DNA. Translation: AAC79992.1. Frameshift.
AF071163 mRNA. Translation: AAC79999.1. Frameshift.
AAAB01008880 Genomic DNA. Translation: EAL40658.2.
RefSeqiXP_562680.2. XM_562680.2.

3D structure databases

ProteinModelPortaliO77462.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP004164-RD; AGAP004164-PD; AGAP004164. [O77462-1]
GeneIDi1273988.
VectorBaseiAGAP004164-RD; AGAP004164-PD; AGAP004164.

Organism-specific databases

CTDi1273988.

Phylogenomic databases

HOGENOMiHOG000125741.
OrthoDBiEOG091G0MS3.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGST1A_ANOGA
AccessioniPrimary (citable) accession number: O77462
Secondary accession number(s): Q5TTE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 18, 2012
Last modified: November 30, 2016
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.