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O77462

- GST1A_ANOGA

UniProt

O77462 - GST1A_ANOGA

Protein

Glutathione S-transferase 1, isoform A

Gene

GstD1

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 3 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei9 – 91GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB

    GO - Biological processi

    1. glutathione metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase 1, isoform A (EC:2.5.1.18)
    Alternative name(s):
    AgGst1-alpha
    Aggst1-3
    GST class-theta
    Gene namesi
    Name:GstD11 Publication
    Synonyms:GST1aImported
    ORF Names:AGAP004164
    OrganismiAnopheles gambiae (African malaria mosquito)
    Taxonomic identifieri7165 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
    ProteomesiUP000007062: Chromosome 2R

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 186186Glutathione S-transferase 1, isoform APRO_0000283092Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO77462.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8181GST N-terminalAdd
    BLAST
    Domaini92 – 18695GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni50 – 523Glutathione bindingBy similarity
    Regioni65 – 673Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Theta family.Sequence Analysis
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    HOGENOMiHOG000125741.
    InParanoidiO77462.
    KOiK00799.
    OrthoDBiEOG7V1FRJ.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform A1 Publication (identifier: O77462-1) [UniParc]FASTAAdd to Basket

    Also known as: 1-31 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDFYYLPGSA PCRAVQMTAA AVGVELNLKL TDLMKGEHMK PEFLKLNPQH    50
    CIPTLVDEDG FVLWESRAIQ IYLVEKYCAH DPALAERLYP GDPRRRAVVH 100
    QRLFFDVAIL YQRFAEYYYP QIFGKKVAGD PDRLRSMEQA LEFLNTFLEG 150
    ERFVAGGDDP TIADFSILAC ILDCNVRRCR VRSAAI 186
    Length:186
    Mass (Da):21,255
    Last modified:April 18, 2012 - v3
    Checksum:i82B9860A3DD57A81
    GO
    Isoform B1 Publication (identifier: O77473-1) [UniParc]FASTAAdd to Basket

    Also known as: 1-41 Publication

    The sequence of this isoform can be found in the external entry O77473.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:216
    Mass (Da):24,492
    GO
    Isoform C1 Publication (identifier: Q93112-1) [UniParc]FASTAAdd to Basket

    Also known as: 1-51 Publication

    The sequence of this isoform can be found in the external entry Q93112.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:209
    Mass (Da):23,783
    GO
    Isoform D1 Publication (identifier: Q93113-1) [UniParc]FASTAAdd to Basket

    Also known as: 1-1, 1-61 Publication

    , 2-1

    The sequence of this isoform can be found in the external entry Q93113.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:209
    Mass (Da):23,445
    GO

    Sequence cautioni

    The sequence AAC79992.1 differs from that shown. Reason: Frameshift at position 172.
    The sequence AAC79999.1 differs from that shown. Reason: Frameshift at position 172.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti170 – 1712Missing in AAC79992. (PubMed:9826692)Curated
    Sequence conflicti170 – 1712Missing in AAC79999. (PubMed:9826692)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071160 Genomic DNA. Translation: AAC79992.1. Frameshift.
    AF071163 mRNA. Translation: AAC79999.1. Frameshift.
    AAAB01008880 Genomic DNA. Translation: EAL40658.2.
    RefSeqiXP_562680.2. XM_562680.2.

    Genome annotation databases

    EnsemblMetazoaiAGAP004164-RD; AGAP004164-PD; AGAP004164. [O77462-1]
    GeneIDi1273988.
    KEGGiaga:AgaP_AGAP004164.
    VectorBaseiAGAP004164. Anopheles gambiae.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071160 Genomic DNA. Translation: AAC79992.1 . Frameshift.
    AF071163 mRNA. Translation: AAC79999.1 . Frameshift.
    AAAB01008880 Genomic DNA. Translation: EAL40658.2 .
    RefSeqi XP_562680.2. XM_562680.2.

    3D structure databases

    ProteinModelPortali O77462.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai AGAP004164-RD ; AGAP004164-PD ; AGAP004164 . [O77462-1 ]
    GeneIDi 1273988.
    KEGGi aga:AgaP_AGAP004164.
    VectorBasei AGAP004164. Anopheles gambiae.

    Organism-specific databases

    CTDi 1273988.

    Phylogenomic databases

    eggNOGi COG0625.
    HOGENOMi HOG000125741.
    InParanoidi O77462.
    KOi K00799.
    OrthoDBi EOG7V1FRJ.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The role of alternative mRNA splicing in generating heterogeneity within the Anopheles gambiae class I glutathione S-transferase family."
      Ranson H., Collins F.H., Hemingway J.
      Proc. Natl. Acad. Sci. U.S.A. 95:14284-14289(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING.
      Strain: ZAN/UImported.
    2. "The genome sequence of the malaria mosquito Anopheles gambiae."
      Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
      , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
      Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PEST.

    Entry informationi

    Entry nameiGST1A_ANOGA
    AccessioniPrimary (citable) accession number: O77462
    Secondary accession number(s): Q5TTE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 91 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3