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Protein

Telomerase reverse transcriptase

Gene

TERT

Organism
Tetrahymena thermophila
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi618Magnesium; catalyticPROSITE-ProRule annotation1
Metal bindingi815Magnesium; catalyticPROSITE-ProRule annotation1
Metal bindingi816Magnesium; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed DNA polymerase, Transferase

Keywords - Ligandi

DNA-binding, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Telomerase reverse transcriptase (EC:2.7.7.49)
Alternative name(s):
Telomerase catalytic subunit
Telomerase subunit P133
Gene namesi
Name:TERT
OrganismiTetrahymena thermophila
Taxonomic identifieri5911 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000549291 – 1117Telomerase reverse transcriptaseAdd BLAST1117

Interactioni

Protein-protein interaction databases

DIPiDIP-60200N.

Structurei

Secondary structure

11117
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 26Combined sources10
Beta strandi32 – 35Combined sources4
Helixi36 – 42Combined sources7
Helixi54 – 62Combined sources9
Beta strandi64 – 69Combined sources6
Helixi73 – 75Combined sources3
Helixi89 – 99Combined sources11
Turni100 – 102Combined sources3
Helixi107 – 109Combined sources3
Beta strandi113 – 115Combined sources3
Beta strandi118 – 120Combined sources3
Turni129 – 132Combined sources4
Helixi134 – 143Combined sources10
Helixi145 – 154Combined sources10
Beta strandi156 – 162Combined sources7
Beta strandi165 – 172Combined sources8
Helixi174 – 181Combined sources8
Beta strandi188 – 190Combined sources3
Beta strandi229 – 231Combined sources3
Beta strandi243 – 245Combined sources3
Helixi281 – 291Combined sources11
Helixi301 – 320Combined sources20
Helixi323 – 330Combined sources8
Helixi337 – 348Combined sources12
Helixi356 – 366Combined sources11
Helixi367 – 369Combined sources3
Helixi373 – 387Combined sources15
Helixi390 – 392Combined sources3
Helixi395 – 410Combined sources16
Helixi419 – 423Combined sources5
Helixi428 – 430Combined sources3
Turni441 – 443Combined sources3
Helixi445 – 466Combined sources22
Helixi468 – 475Combined sources8
Beta strandi476 – 483Combined sources8
Beta strandi488 – 492Combined sources5
Helixi493 – 509Combined sources17
Turni510 – 516Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B2AX-ray2.22A/B/C2-191[»]
2R4GX-ray1.71A254-519[»]
5C9HX-ray3.00A/B217-516[»]
ProteinModelPortaliO77448.
SMRiO77448.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO77448.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini517 – 881Reverse transcriptasePROSITE-ProRule annotationAdd BLAST365

Sequence similaritiesi

Contains 1 reverse transcriptase domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR000477. RT_dom.
IPR021891. Telomerase_RBD.
IPR003545. Telomerase_RT.
[Graphical view]
PANTHERiPTHR12066:SF0. PTHR12066:SF0. 2 hits.
PfamiPF00078. RVT_1. 1 hit.
PF12009. Telomerase_RBD. 1 hit.
[Graphical view]
PRINTSiPR01365. TELOMERASERT.
SMARTiSM00975. Telomerase_RBD. 1 hit.
[Graphical view]
PROSITEiPS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O77448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKINNINNN KQMLTRKEDL LTVLKQISAL KYVSNLYEFL LATEKIVQTS
60 70 80 90 100
ELDTQFQEFL TTTIIASEQN LVENYKQKYN QPNFSQLTIK QVIDDSIILL
110 120 130 140 150
GNKQNYVQQI GTTTIGFYVE YENINLSRQT LYSSNFRNLL NIFGEEDFKY
160 170 180 190 200
FLIDFLVFTK VEQNGYLQVA GVCLNQYFSV QVKQKKWYKN NFNMNGKATS
210 220 230 240 250
NNNQNNANLS NEKKQENQYI YPEIQRSQIF YCNHMGREPG VFKSSFFNYS
260 270 280 290 300
EIKKGFQFKV IQEKLQGRQF INSDKIKPDH PQTIIKKTLL KEYQSKNFSC
310 320 330 340 350
QEERDLFLEF TEKIVQNFHN INFNYLLKKF CKLPENYQSL KSQVKQIVQS
360 370 380 390 400
ENKANQQSCE NLFNSLYDTE ISYKQITNFL RQIIQNCVPN QLLGKKNFKV
410 420 430 440 450
FLEKLYEFVQ MKRFENQKVL DYICFMDVFD VEWFVDLKNQ KFTQKRKYIS
460 470 480 490 500
DKRKILGDLI VFIINKIVIP VLRYNFYITE KHKEGSQIFY YRKPIWKLVS
510 520 530 540 550
KLTIVKLEEE NLEKVEEKLI PEDSFQKYPQ GKLRIIPKKG SFRPIMTFLR
560 570 580 590 600
KDKQKNIKLN LNQILMDSQL VFRNLKDMLG QKIGYSVFDN KQISEKFAQF
610 620 630 640 650
IEKWKNKGRP QLYYVTLDIK KCYDSIDQMK LLNFFNQSDL IQDTYFINKY
660 670 680 690 700
LLFQRNKRPL LQIQQTNNLN SAMEIEEEKI NKKPFKMDNI NFPYYFNLKE
710 720 730 740 750
RQIAYSLYDD DDQILQKGFK EIQSDDRPFI VINQDKPRCI TKDIIHNHLK
760 770 780 790 800
HISQYNVISF NKVKFRQKRG IPQGLNISGV LCSFYFGKLE EEYTQFLKNA
810 820 830 840 850
EQVNGSINLL MRLTDDYLFI SDSQQNALNL IVQLQNCANN NGFMFNDQKI
860 870 880 890 900
TTNFQFPQED YNLEHFKISV QNECQWIGKS IDMNTLEIKS IQKQTQQEIN
910 920 930 940 950
QTINVAISIK NLKSQLKNKL RSLFLNQLID YFNPNINSFE GLCRQLYHHS
960 970 980 990 1000
KATVMKFYPF MTKLFQIDLK KSKQYSVQYG KENTNENFLK DILYYTVEDV
1010 1020 1030 1040 1050
CKILCYLQFE DEINSNIKEI FKNLYSWIMW DIIVSYLKKK KQFKGYLNKL
1060 1070 1080 1090 1100
LQKIRKSRFF YLKEGCKSLQ LILSQQKYQL NKKELEAIEF IDLNNLIQDI
1110
KTLIPKISAK SNQQNTN
Length:1,117
Mass (Da):133,318
Last modified:November 1, 1998 - v1
Checksum:iE5AF15E86B0F0CD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062652 Genomic DNA. Translation: AAC39135.1.
AF061284 mRNA. Translation: AAC39140.1.
PIRiT14891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062652 Genomic DNA. Translation: AAC39135.1.
AF061284 mRNA. Translation: AAC39140.1.
PIRiT14891.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B2AX-ray2.22A/B/C2-191[»]
2R4GX-ray1.71A254-519[»]
5C9HX-ray3.00A/B217-516[»]
ProteinModelPortaliO77448.
SMRiO77448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60200N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO77448.

Family and domain databases

InterProiIPR000477. RT_dom.
IPR021891. Telomerase_RBD.
IPR003545. Telomerase_RT.
[Graphical view]
PANTHERiPTHR12066:SF0. PTHR12066:SF0. 2 hits.
PfamiPF00078. RVT_1. 1 hit.
PF12009. Telomerase_RBD. 1 hit.
[Graphical view]
PRINTSiPR01365. TELOMERASERT.
SMARTiSM00975. Telomerase_RBD. 1 hit.
[Graphical view]
PROSITEiPS50878. RT_POL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTERT_TETTH
AccessioniPrimary (citable) accession number: O77448
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.