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O77440 (O77440_HYDVU) Unreviewed, UniProtKB/TrEMBL

Last modified March 6, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase PIRNR PIRNR000604
EC=2.7.10.2 PIRNR PIRNR000604
Gene names
Name:HTK98 EMBL AAC28629.1
OrganismHydra vulgaris (Hydra) (Hydra attenuata) EMBL AAC28629.1
Taxonomic identifier6087 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Cnidaria › Hydrozoa › Hydroida › Anthomedusae › Hydridae › Hydra

Protein attributes

Sequence length624 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. PIRNR PIRNR000604 SAAS SAAS008266

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. PIRNR PIRNR000604

Contains 1 protein kinase domain. SAAS SAAS008266

Sequences

Sequence LengthMass (Da)Tools
O77440 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 626DDD0C1B13162B

FASTA62471,487
        10         20         30         40         50         60 
MADPSLLRWF HGRITRDIAE NCLQTTTSMD DGTYLLRESA SEIGSYVLSV CKDKKVIHYA 

        70         80         90        100        110        120 
IQRQPSGMVG IADGPQFPGP VELVNHHKTS LGGLMTKLTY PCERPAGVKA TAYKGISHDD 

       130        140        150        160        170        180 
LDEAIRTVLR TEGVVNEEAV RKFKVKMEYV VGNILHRQQP WFHGVIPRTE AERRLKSLSE 

       190        200        210        220        230        240 
TGMFLIRERG SPRGSYVIGL FYQGGVYHYL FESNNQGQLS IKSGRSFDNL MAVVNFYSQK 

       250        260        270        280        290        300 
SEGLFCTLKR ACEVSWFEFQ PKTEIYKNIL LHPEIQAELK KTLLLYEDEL KKYRRVSRVE 

       310        320        330        340        350        360 
RPPVPNRPVS RVSNQIDVKD TWVYEKIYDS KDIVKKEGFK NPFETQERET ELDPKRLRLE 

       370        380        390        400        410        420 
HELGHGNFGS VVKGVYLLKN NKSVAVAVKT LKEEDIPGQK SEIVKEAEIM SKLDHPNIVR 

       430        440        450        460        470        480 
LIGVTQSPGF MLVMELAPQG PLHKFLKKNR NMNVLDILVL MLQVDEGMNY LESQHFVHRD 

       490        500        510        520        530        540 
LAARNVLVVS ENFVKISDFG MSRAMGVGNE YYRAERAGKW PLKWYAPECI YYHKFSSKGD 

       550        560        570        580        590        600 
VWSYGITMWE AVSYGGKPYQ GMRGPVIVEK LESGYRLPKP DNCSDAVYTL MLKCWETNPD 

       610        620 
DRPSFMEIGI ILAQYIQNER VKKK

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References

[1]"The syk family of protein-tyrosine kinases appeared early in metazoan evolution."
Steele R.E., Sakaguchi M.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: UCI EMBL AAC28629.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF060949 mRNA. Translation: AAC28629.1.

3D structure databases

HSSPHSSP built from PDB template 1JPA based on UniProtKB P54763.
ProteinModelPortalO77440.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.505.10. 2 hits.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR012234. Tyr_kinase_non-rcpt_SYK/ZAP70.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 2 hits.
[Graphical view]
PIRSFPIRSF000604. TyrPK_SYK. 1 hit.
PRINTSPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTSM00252. SH2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameO77440_HYDVU
AccessionPrimary (citable) accession number: O77440
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: March 6, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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