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Protein

Male-specific histamine-binding salivary protein

Gene
N/A
Organism
Rhipicephalus appendiculatus (Brown ear tick)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Binds histamine with a high-affinity. The ability to outcompete histamine receptors indicates that its function is to suppress inflammation during blood feeding.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Male-specific histamine-binding salivary protein
Short name:
MS-HBP
OrganismiRhipicephalus appendiculatus (Brown ear tick)
Taxonomic identifieri34631 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusRhipicephalus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 200182Male-specific histamine-binding salivary proteinPRO_0000021401Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi65 ↔ 193By similarity
Disulfide bondi137 ↔ 169By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliO77422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002970. Tick_his-bd.
[Graphical view]
PfamiPF02098. His_binding. 1 hit.
[Graphical view]
PRINTSiPR01220. HISBINDING.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77422-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLLLVLGA ALCQNADANP TWANEAKLGS YQDAWKSLQQ DQNKRYYLAQ
60 70 80 90 100
ATQTTDGVWG EEFTCVSVTA EKIGKKKLNA TILYKNKHLT DLKESHETIT
110 120 130 140 150
VWKAYDYTTE NGIKYETQGT RTQTFEDVFV FSDYKNCDVI FVPKERGSDE
160 170 180 190 200
GDYELWVSED KIDKIPDCCK FTMAYFAQQQ EKTVRNVYTD SSCKPAPAQN
Length:200
Mass (Da):22,852
Last modified:November 1, 1998 - v1
Checksum:iC46A1C8C6BCAA008
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96082 mRNA. Translation: AAC63108.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96082 mRNA. Translation: AAC63108.1.

3D structure databases

ProteinModelPortaliO77422.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002970. Tick_his-bd.
[Graphical view]
PfamiPF02098. His_binding. 1 hit.
[Graphical view]
PRINTSiPR01220. HISBINDING.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Tick histamine-binding proteins: isolation, cloning, and three-dimensional structure."
    Paesen G.C., Adams P.L., Harlos K., Nuttall P.A., Stuart D.I.
    Mol. Cell 3:661-671(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Salivary gland.

Entry informationi

Entry nameiHBPM_RHIAP
AccessioniPrimary (citable) accession number: O77422
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: January 20, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.