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Protein

Female-specific histamine-binding protein 2

Gene
N/A
Organism
Rhipicephalus appendiculatus (Brown ear tick)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds histamine with a high-affinity. The ability to outcompete histamine receptors indicates that its function is to suppress inflammation during blood feeding.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Female-specific histamine-binding protein 2
Short name:
FS-HBP2
OrganismiRhipicephalus appendiculatus (Brown ear tick)
Taxonomic identifieri34631 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusRhipicephalus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000002140020 – 190Female-specific histamine-binding protein 2Add BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi67 ↔ 188
Disulfide bondi138 ↔ 167

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi27 – 30Combined sources4
Helixi31 – 33Combined sources3
Helixi36 – 45Combined sources10
Beta strandi48 – 54Combined sources7
Beta strandi56 – 58Combined sources3
Turni59 – 61Combined sources3
Beta strandi66 – 76Combined sources11
Turni77 – 80Combined sources4
Beta strandi81 – 90Combined sources10
Beta strandi93 – 106Combined sources14
Beta strandi116 – 121Combined sources6
Beta strandi126 – 135Combined sources10
Beta strandi138 – 143Combined sources6
Beta strandi147 – 149Combined sources3
Beta strandi152 – 158Combined sources7
Beta strandi160 – 164Combined sources5
Helixi165 – 174Combined sources10
Turni175 – 177Combined sources3
Helixi186 – 188Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QFTX-ray1.25A/B20-190[»]
1QFVX-ray1.36A/B20-190[»]
3G7XX-ray1.55A/B20-190[»]
3GAQX-ray2.25A/B20-190[»]
ProteinModelPortaliO77421.
SMRiO77421.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO77421.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002970. Tick_his-bd.
[Graphical view]
PfamiPF02098. His_binding. 1 hit.
[Graphical view]
PRINTSiPR01220. HISBINDING.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77421-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLILSLAL VLALSQVKGN QPDWADEAAN GAHQDAWKSL KADVENVYYM
60 70 80 90 100
VKATYKNDPV WGNDFTCVGV MANDVNEDEK SIQAEFLFMN NADTNMQFAT
110 120 130 140 150
EKVTAVKMYG YNRENAFRYE TEDGQVFTDV IAYSDDNCDV IYVPGTDGNE
160 170 180 190
EGYELWTTDY DNIPANCLNK FNEYAVGRET RDVFTSACLE
Length:190
Mass (Da):21,464
Last modified:November 1, 1998 - v1
Checksum:i6923A3E902552B6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96081 mRNA. Translation: AAC63107.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96081 mRNA. Translation: AAC63107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QFTX-ray1.25A/B20-190[»]
1QFVX-ray1.36A/B20-190[»]
3G7XX-ray1.55A/B20-190[»]
3GAQX-ray2.25A/B20-190[»]
ProteinModelPortaliO77421.
SMRiO77421.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO77421.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002970. Tick_his-bd.
[Graphical view]
PfamiPF02098. His_binding. 1 hit.
[Graphical view]
PRINTSiPR01220. HISBINDING.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHBP2_RHIAP
AccessioniPrimary (citable) accession number: O77421
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.