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Protein

Female-specific histamine-binding protein 1

Gene
N/A
Organism
Rhipicephalus appendiculatus (Brown ear tick)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Binds histamine with a high-affinity. The ability to outcompete histamine receptors indicates that its function is to suppress inflammation during blood feeding.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Female-specific histamine-binding protein 1
Short name:
FS-HBP1
OrganismiRhipicephalus appendiculatus (Brown ear tick)
Taxonomic identifieri34631 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusRhipicephalus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 190172Female-specific histamine-binding protein 1PRO_0000021399Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi66 ↔ 187By similarity
Disulfide bondi137 ↔ 166By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliO77420.
SMRiO77420. Positions 19-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002970. Tick_his-bd.
[Graphical view]
PfamiPF02098. His_binding. 1 hit.
[Graphical view]
PRINTSiPR01220. HISBINDING.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77420-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLLSLAFV LALSQVKADK PVWADEAANG EHQDAWKHLQ KLVEENYDLI
60 70 80 90 100
KATYKNDPVW GNDFTCVGTA AQNLNEDEKN VEAWFMFMNN ADTVYQHTFE
110 120 130 140 150
KATPDKMYGY NKENAITYQT EDGQVLTDVL AFSDDNCYVI YALGPDGSGA
160 170 180 190
GYELWATDYT DVPASCLEKF NEYAAGLPVR DVYTSDCLPE
Length:190
Mass (Da):21,370
Last modified:November 1, 1998 - v1
Checksum:i855BE151A90053B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96080 mRNA. Translation: AAC63106.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96080 mRNA. Translation: AAC63106.1.

3D structure databases

ProteinModelPortaliO77420.
SMRiO77420. Positions 19-188.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002970. Tick_his-bd.
[Graphical view]
PfamiPF02098. His_binding. 1 hit.
[Graphical view]
PRINTSiPR01220. HISBINDING.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Tick histamine-binding proteins: isolation, cloning, and three-dimensional structure."
    Paesen G.C., Adams P.L., Harlos K., Nuttall P.A., Stuart D.I.
    Mol. Cell 3:661-671(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Salivary gland.

Entry informationi

Entry nameiHBP1_RHIAP
AccessioniPrimary (citable) accession number: O77420
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: January 20, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.