Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Octopamine receptor 1

Gene
N/A
Organism
Lymnaea stagnalis (Great pond snail) (Helix stagnalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. Activation of this receptor by octopamine induces an increase in both inositol phosphates and cyclic AMP. The coupling to adenylyl cyclase seems to be less efficient than the coupling to phospholipase C. The rank order of potency for agonists is p-synephrine >= clonidine > p-octopamine = xylometazoline = phenylephrine = oxymetazoline > B-HT920 > serotonin = p-tyramine > epinephrine > norepinephrine > methoxamine = dopamine = histamine. For antagonists, the rank order is yohimbine > chlopromazine / spiperone > phentolamine > mianserine > rauwolscine > prazosin > alprenolol / propanolol > pindolol.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Octopamine receptor 1
Short name:
OA1
OrganismiLymnaea stagnalis (Great pond snail) (Helix stagnalis)
Taxonomic identifieri6523 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraPanpulmonataHygrophilaLymnaeoideaLymnaeidaeLymnaea

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence analysisAdd
BLAST
Transmembranei29 – 5325Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini54 – 6411CytoplasmicSequence analysisAdd
BLAST
Transmembranei65 – 8723Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini88 – 10215ExtracellularSequence analysisAdd
BLAST
Transmembranei103 – 12422Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini125 – 14723CytoplasmicSequence analysisAdd
BLAST
Transmembranei148 – 16720Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini168 – 23972ExtracellularSequence analysisAdd
BLAST
Transmembranei240 – 25920Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini260 – 520261CytoplasmicSequence analysisAdd
BLAST
Transmembranei521 – 54525Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini546 – 5516ExtracellularSequence analysis
Transmembranei552 – 57524Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini576 – 63863CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Octopamine receptor 1PRO_0000069956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi101 ↔ 230PROSITE-ProRule annotation
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence analysis
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence analysis
Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed in the central nervous system.

Structurei

3D structure databases

ProteinModelPortaliO77408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000995. Musac_Ach_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O77408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRDIFMKRL RLHLLFDEVA MVTHIVGDVL SSVLLCAVVL LVLVGNTLVV
60 70 80 90 100
AAVATSRKLR TVTNVFIVNL ACADLLLGVL VLPFSAVNEI KDVWIFGHVW
110 120 130 140 150
CQVWLAVDVW LCTASILNLC CISLDRYLAI TRPIRYPGLM SAKRAKTLVA
160 170 180 190 200
GVWLFSFVIC CPPLIGWNDG GDGIMDYNGT TATPIPVTTT QTPVTGRDDV
210 220 230 240 250
LCDNGFNYST NSNMNTTCTY SGDSSLSTTC ELTNSRGYRI YAALGSFFIP
260 270 280 290 300
MLVMVFFYLQ IYRAAVKTIS AYAKGELKTK YSVRENGSKT NSVTLRIHRG
310 320 330 340 350
GRGPSTGSSV YRHGSTYGGS AAGAATREGC GDKDAAGGRR FGRQEMDSHL
360 370 380 390 400
PVRKCRSSDA SLVTLTGLKC EIIDNGNAKH GPISELIKGR GKSFFWRKEK
410 420 430 440 450
KRSVGGERES FENSTRNGRS TRAKLCGGRC LAIETDICSS GECSPRTKRI
460 470 480 490 500
KEHARATQHN SLPVTPSLSS QNEETDAVFV RGTSNSEYKP RRSRLSAHKP
510 520 530 540 550
GHAMRLHMQK FNREKKAAKT LAIIVGAFIM CWMPFFTIYL VGAFCENCIS
560 570 580 590 600
PIVFSVAFWL GYCNSAMNPC VYALFSRDFR FAFRKLLTCS CKAWSKNRSF
610 620 630
RPQTSDVPAI QLHCATQDDA KSSSDIGPTA SGGNGGYT
Length:638
Mass (Da):70,001
Last modified:November 1, 1998 - v1
Checksum:i65FA928B5C01D34F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62771 mRNA. Translation: AAC61296.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62771 mRNA. Translation: AAC61296.1.

3D structure databases

ProteinModelPortaliO77408.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000995. Musac_Ach_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOAR1_LYMST
AccessioniPrimary (citable) accession number: O77408
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.