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Protein
Submitted name:

P-type ATPase, putative

Gene

PF3D7_0319000

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Source: GeneDB
  • ATP binding Source: UniProtKB-KW
  • magnesium ion binding Source: InterPro
  • phospholipid-translocating ATPase activity Source: GO_Central
  • transporter activity Source: GeneDB

GO - Biological processi

  • cation transport Source: GeneDB
  • Golgi vesicle budding Source: GO_Central
  • ion transmembrane transport Source: GOC
  • phospholipid translocation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-PFA-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Submitted name:
P-type ATPase, putativeImported (EC:3.6.3.1Imported)
Gene namesi
ORF Names:PF3D7_0319000Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0319000.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei70 – 9122HelicalSequence analysisAdd
BLAST
Transmembranei111 – 12818HelicalSequence analysisAdd
BLAST
Transmembranei538 – 56730HelicalSequence analysisAdd
BLAST
Transmembranei587 – 61125HelicalSequence analysisAdd
BLAST
Transmembranei1496 – 152126HelicalSequence analysisAdd
BLAST
Transmembranei1533 – 155018HelicalSequence analysisAdd
BLAST
Transmembranei1638 – 165922HelicalSequence analysisAdd
BLAST
Transmembranei1679 – 170022HelicalSequence analysisAdd
BLAST
Transmembranei1707 – 172721HelicalSequence analysisAdd
BLAST
Transmembranei1755 – 177622HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi membrane Source: GOC
  • integral component of plasma membrane Source: GeneDB
  • plasma membrane Source: GO_Central
  • trans-Golgi network Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliO77368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 10547PhoLip_ATPase_NInterPro annotationAdd
BLAST
Domaini1466 – 1781316PhoLip_ATPase_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOGENOMiHOG000283197.
InParanoidiO77368.
OMAiEMGNVTH.
PhylomeDBiO77368.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 3 hits.
3.40.50.1000. 3 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 7 hits.
PfamiPF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O77368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILEWISCT IKGKHNENKI YLISNFEFNK DDHEYYIKNA ENRIKEEDLN
60 70 80 90 100
IDIIYGKKHK NEIRTAKYKL YSFLPLIVFF QFLRLGNLYF LSISMLQLIP
110 120 130 140 150
EITDSKGMPT YLIPLVFIIV VAMIKEFFED WQRHKSDNEE NSKKTMVFVQ
160 170 180 190 200
GELKEKKWAD VKDGDVVKIF SYEYFPADLI VLNCSNKKGI VNIETKNVDG
210 220 230 240 250
ESNVKQKYCL PDISKYFSDD KTAGFCRIEL ISERPNDNIF DYKGYMILPP
260 270 280 290 300
LQYKNMKNGK LIHFYNTHYK MDDHKDEHDE KGTGKYINKN YKNDYNDKHI
310 320 330 340 350
SYNTNEQNNL SDMTKNDPKE YDYNPQNEIN NNNNNNNCDN NNNNCNNNNR
360 370 380 390 400
FFVDDIKKQG QNEETVDKKK SFFIINNQKK VYDTGSSNND QITHINNDVI
410 420 430 440 450
SEKKRASRRR TLYNKLTFNK SFFNNKNENK KLNKRNSTLS SINNNNDNNN
460 470 480 490 500
NNNNNNNNIH NREYDGEEQT LKKENFFFKE YKRDQKFVQI TIDNLVLRGT
510 520 530 540 550
SLVNTKWIYG LVINTGNRTK LMKNASTKSR QKWSRLEFVY GNHVIVLIIC
560 570 580 590 600
QVFISLIVAI AGVLWMRRKG YTLWYLNLDQ TSDSLKTFFI TIGSMVLLFG
610 620 630 640 650
SFIPVDLLLI WEVVRLLQGY LINWDNDMYS EKTGRHALSK AGQLLEEMGN
660 670 680 690 700
VTHIYSDKTG TLTQNVMQLQ NIGLGNKGTY GFYDFSNIKE NITKSRHWGS
710 720 730 740 750
QDPMDPVLEE YENEENVYSN VNDDNKNDHG TNESDDNNNN NNNNDDDDHH
760 770 780 790 800
DNNHNIHNDQ NNNAQYDNYD NYYLNNHQQQ NKVKNRPCID DETNFYRNNN
810 820 830 840 850
MNKERTRKSY TFLNPLNWSN TSINTKMKKK KSLFYNKNSL ANYESLLNNT
860 870 880 890 900
YTEDDFIRGE NEFVFFNRIL FVNKIYSIRH DVQDQIYFLL LVLSLCHSAM
910 920 930 940 950
IRNVDIDEMD NNEDDNNNNE KLKIYDKETD IVYTYITQTQ PQYDASSPDE
960 970 980 990 1000
LALISTSLYL GCEFVNRPNL TTIEIELTST FAQRFILGEK KFEKFLEKKE
1010 1020 1030 1040 1050
FYEKEFDTYF PDISACLGKE KKKDNNKINE MINNKGNTKD DYMNNFHMSI
1060 1070 1080 1090 1100
PIKNIFGSNK MQYKEEIKYE EKIIKKVVPI LSFEILDVFA FDNVRKRMSL
1110 1120 1130 1140 1150
IVKNEKKEIF MLVKGADTSV LKLASKNQEN IVDHVEHQLH AFATSGLRTL
1160 1170 1180 1190 1200
VLGYKYLTEN EFSDMYRNHI NARKKSETDK EEYLQEFYEE AENNLIIIGC
1210 1220 1230 1240 1250
TGIDDKLQDD VPQVIQDLRD AGMTICVLTG DKLETAINIG HSINILNKQT
1260 1270 1280 1290 1300
YNAIFTETDP TLLLEQLNIH EKNTNAANLL NVDHGTKWWN SVNWEHLNLD
1310 1320 1330 1340 1350
LRSETILNFM KSNFHGSLKK SIISSNMFNM KNNNSFPSLA RQDKVFNSFL
1360 1370 1380 1390 1400
ESSESFCHNN NEMDKTKGKE KVHYSQFSIT ITGEALDVIM KDKILKIKFY
1410 1420 1430 1440 1450
TLARSASTLI ACRVTPKQKS LLVKENSAFN PRGTSLAIGD GANDVGMILM
1460 1470 1480 1490 1500
ANVGVGIAGK EGLQAARSSD FTISEFKYLK KLLFVHGRES LRRNSFLVYF
1510 1520 1530 1540 1550
CIFRNVSFCL CSMILIFWTG YSAIDAWNPW TKQIINIAFT SLPVIFFVAL
1560 1570 1580 1590 1600
DKQLPHNILL NNPLLYETSP STLWPFYSNR KMEFYTNKVK GCYKSFYKFC
1610 1620 1630 1640 1650
FFPIRYIPYI QRYTEKIKSW IGKRSKPEKY RTYGTHYLFV YLLFAIWLAT
1660 1670 1680 1690 1700
VETVIMLHFS TGQAYSSSLK DNHHVDIDFN TFSQILYTHH VIAVNIVVVL
1710 1720 1730 1740 1750
MTNTWFFISH VVLWIELIAT FFFWFIISNT KFFLDIIGAD ELHGTFEKAH
1760 1770 1780 1790 1800
SSGNYYASLI ISLYISILPL IILMTYQFIK KPTMEQIVLE QLKLGKFEGL
1810 1820 1830 1840 1850
RKHEIKKLAY IDNQKSSNEF THKGFAFAVE AKEAFWGLVQ KAIYKIKMPL
1860
VKDETANIKH KRKS
Length:1,864
Mass (Da):218,020
Last modified:November 1, 1998 - v1
Checksum:i6A425F4410B1E667
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844502 Genomic DNA. Translation: CAB11124.1.
PIRiT18485.
RefSeqiXP_001351260.1. XM_001351224.1.

Genome annotation databases

EnsemblProtistsiPFC0840w:mRNA; PFC0840w:pep; PFC0840w.
GeneDBiPF3D7_0319000.1:pep.
GeneIDi814504.
KEGGipfa:PFC0840w.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844502 Genomic DNA. Translation: CAB11124.1.
PIRiT18485.
RefSeqiXP_001351260.1. XM_001351224.1.

3D structure databases

ProteinModelPortaliO77368.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPFC0840w:mRNA; PFC0840w:pep; PFC0840w.
GeneDBiPF3D7_0319000.1:pep.
GeneIDi814504.
KEGGipfa:PFC0840w.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0319000.

Phylogenomic databases

HOGENOMiHOG000283197.
InParanoidiO77368.
OMAiEMGNVTH.
PhylomeDBiO77368.

Enzyme and pathway databases

ReactomeiR-PFA-936837. Ion transport by P-type ATPases.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 3 hits.
3.40.50.1000. 3 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 7 hits.
PfamiPF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7Imported.
  3. "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."
    Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z.
    , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G.
    Nature 419:527-531(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7Imported.

Entry informationi

Entry nameiO77368_PLAF7
AccessioniPrimary (citable) accession number: O77368
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.