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Protein

Serine/threonine-protein phosphatase

Gene

PpN58A

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: FlyBase

GO - Biological processi

  • protein dephosphorylation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation

Keywords - Ligandi

ManganeseSAAS annotation, Metal-bindingSAAS annotation

Enzyme and pathway databases

SignaLinkiO77294.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation)
Gene namesi
Name:PpN58AImported
Synonyms:PPN 58AImported
ORF Names:CG3245Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0025573. PpN58A.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO77294.
PRIDEiO77294.

Expressioni

Gene expression databases

BgeeiO77294.
ExpressionAtlasiO77294. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0071650.

Structurei

3D structure databases

ProteinModelPortaliO77294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 1396SER_THR_PHOSPHATASEInterPro annotation

Sequence similaritiesi

Belongs to the PPP phosphatase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IN82. Eukaryota.
ENOG410Y2WA. LUCA.
HOGENOMiHOG000252499.
OrthoDBiEOG73FQMZ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O77294-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKKLLSNGS NKNKTLKFDE GINLDQIIAK LKLIGEIGSV IQISVREIEA
60 70 80 90 100
VCSRAREVLL KQPTLLEIPA PINLLGDIHG QYLNLLRYFE SNGYPPDSVY
110 120 130 140 150
LLLGDYVDRG KQSIETLTLL LALKARYPTK FYLLRGNHEC SSINHFYGFY
160 170 180 190 200
DECKRRYTVK LWRTFVDCYN CLPLAAIIEE NIFCCHGGLS PHLFSMQQIR
210 220 230 240 250
EIRRPIEIPE SGLICDILWS DPDLRIMGWG PNERGVSHTF GSDVVSAFLH
260 270 280 290 300
RFKLNLICRG HQVVEDGYEF FAKRQLITIF SAPNYCGEFD NAGAMMCINQ
310 320
DLLCTFRVQR PILSEQRRLS DISV
Length:324
Mass (Da):37,107
Last modified:November 1, 1998 - v1
Checksum:i196D1CC5F13DCA97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17355 Genomic DNA. Translation: CAA76756.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17355 Genomic DNA. Translation: CAA76756.1.

3D structure databases

ProteinModelPortaliO77294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0071650.

Proteomic databases

PaxDbiO77294.
PRIDEiO77294.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0025573. PpN58A.

Phylogenomic databases

eggNOGiENOG410IN82. Eukaryota.
ENOG410Y2WA. LUCA.
HOGENOMiHOG000252499.
OrthoDBiEOG73FQMZ.

Enzyme and pathway databases

SignaLinkiO77294.

Gene expression databases

BgeeiO77294.
ExpressionAtlasiO77294. differential.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of a novel testis specific protein serine/threonine phosphatase, PPN 58A, from Drosophila melanogaster."
    Armstrong C.G., Dombradi V., Mann D.J., Cohen P.T.
    Biochim. Biophys. Acta 1399:234-238(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Canton SImported.

Entry informationi

Entry nameiO77294_DROME
AccessioniPrimary (citable) accession number: O77294
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.