Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Eyegone

Gene

eyg

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • RNA polymerase II regulatory region sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • antennal development Source: FlyBase
  • compound eye development Source: FlyBase
  • compound eye morphogenesis Source: FlyBase
  • eye-antennal disc development Source: FlyBase
  • eye development Source: FlyBase
  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • notum development Source: FlyBase
  • salivary gland morphogenesis Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DME-210746. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.

Names & Taxonomyi

Protein namesi
Submitted name:
EyegoneImported
Gene namesi
Name:eygImported
ORF Names:CG10488Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0000625. eyg.

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

  • nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiO77238.
PRIDEiO77238.

Expressioni

Gene expression databases

BgeeiO77238.
ExpressionAtlasiO77238. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0075711.

Structurei

3D structure databases

ProteinModelPortaliO77238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 103103PairedInterPro annotationAdd
BLAST
Domaini230 – 29061Homeobox DNA-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 paired domain.UniRule annotation

Keywords - Domaini

HomeoboxUniRule annotation, Paired boxUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
OrthoDBiEOG7SR4MC.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O77238-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQHRLLEFS RFGGLRGYDI AQHMLTQQGA VSKLLGSLRP PGLIGGSKPK
60 70 80 90 100
VATPTVVSKI EQYKRENPTI FAWEIRERLI SEGVCTNATA PSVSSINRIL
110 120 130 140 150
RNRAAERVAT EFARTAAYGL YPPPPHPYGS FTWHPAGNVP GGQGVPPPPP
160 170 180 190 200
PSALWSVAAP TLANLPPSAA SAVPVSTCGS LSSAHLMAGG AGGTPTNRAI
210 220 230 240 250
SPGSGSHDTL ESADENRHID SDYLDDDDEP KFRRNRTTFS PEQLEELEKE
260 270 280 290 300
FDKSHYPCVS TRERLSSRTS LSEARVQVWF SNRRAKWRRH QRMNLLKRQR
310 320 330 340 350
SSPANPLHSQ QSNDAPASSP TPSNHSSAST SAPVAPVPPP QQPLPLCGDH
360 370 380 390 400
SPQGPPPSVL LHPLHGPPGG HHHHHPLHLP THPAALQLLS HYHQQQQQQQ
410 420 430 440 450
QQQHQQQQQQ HHQQQQQLSP SGCNPAANHL SMGGERSAFR SLVSSPSAPA
460 470 480 490 500
FLGLARQYAV AASLTVAEEQ RSRLHYSAGG LGSGGEGTGP NTNTTQSGGS
510 520
TMTVDNSSSD SDEEINVHDD SRW
Length:523
Mass (Da):56,495
Last modified:November 1, 1998 - v1
Checksum:i9A33F12E86D9F67E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091739 mRNA. Translation: AAC78330.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091739 mRNA. Translation: AAC78330.1.

3D structure databases

ProteinModelPortaliO77238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0075711.

Proteomic databases

PaxDbiO77238.
PRIDEiO77238.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0000625. eyg.

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
OrthoDBiEOG7SR4MC.

Enzyme and pathway databases

ReactomeiR-DME-210746. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.

Gene expression databases

BgeeiO77238.
ExpressionAtlasiO77238. differential.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Lune/eye gone, a Pax-like protein, uses a partial paired domain and a homeodomain for DNA recognition."
    Jun S., Wallen R.V., Goriely A., Kalionis B., Desplan C.
    Proc. Natl. Acad. Sci. U.S.A. 95:13720-13725(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO77238_DROME
AccessioniPrimary (citable) accession number: O77238
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.