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Protein

Catalase-A

Gene

catA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.1 Publication

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54PROSITE-ProRule annotation1
Active sitei128PROSITE-ProRule annotation1
Metal bindingi338Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • catalase activity Source: dictyBase
  • heme binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • hydrogen peroxide catabolic process Source: dictyBase
  • response to hydrogen peroxide Source: GO_Central
  • response to methanol Source: dictyBase
  • response to oxidative stress Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-DDI-3299685. Detoxification of Reactive Oxygen Species.
R-DDI-6798695. Neutrophil degranulation.
R-DDI-74259. Purine catabolism.

Protein family/group databases

PeroxiBasei4096. DdKat01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-A (EC:1.11.1.6)
Gene namesi
Name:catA
Synonyms:cat
ORF Names:DDB_G0274595
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0274595. catA.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: GO_Central
  • peroxisome Source: dictyBase
  • phagocytic vesicle Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Disruption phenotypei

Cells are resistant to methanol, acriflavine and thiabendazole.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000849111 – 496Catalase-AAdd BLAST496

Proteomic databases

PaxDbiO77229.

Expressioni

Developmental stagei

Expressed throughout growth and development. Exclusively localized in the prestalk cells.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0185123.

Structurei

3D structure databases

ProteinModelPortaliO77229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi494 – 496Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiKOG0047. Eukaryota.
COG0753. LUCA.
InParanoidiO77229.
KOiK03781.
OMAiRYNHREG.
PhylomeDBiO77229.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O77229-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPVLTTSS GSPIDNNLNS MTAGVNGPIL IQDFTLIDKL AHFDRERIPE
60 70 80 90 100
RVVHAKGAGA HGYFEVPSSD VPKWCKAKFL NKVGKRTPIF TRFSTVGGEK
110 120 130 140 150
GSSDSERDPR GFAVKFYTEE GNFDMVGNNT PVFFIRDPSK FPDFIHTQKR
160 170 180 190 200
NPQTNCKDPN MFWDFLGQTP ESTHQVSILF SDRGTPKSYR HMHGFSSHTL
210 220 230 240 250
KFVNAQGKPY WVKLHFTSET GIQNYTAEEA AKMSMNDPDS ATRDLFETIA
260 270 280 290 300
KGGEPAWKVS IQLMEFEDAL KYRFNPFDVT KIWSHKDYPL IQIGRMVLNR
310 320 330 340 350
NPENYFAEVE QAAFSPSHMV PGIEPSPDKM LQGRLFSYPD THRHRLGVNY
360 370 380 390 400
QQIPVNCPFA VKGGVKNYQR DGFMAVNGNG GKGPNYQPNS FGGPEPHPEF
410 420 430 440 450
AQHKFDVSGF AARQPYNHPN DDFVQPGDLY RLMSEDAKSR FVSNLVGHMS
460 470 480 490
GVTIKEIQVR AVSNFYKADK DLGARLCKGL GIDVNDVIKF AARSNL
Length:496
Mass (Da):55,680
Last modified:December 4, 2007 - v2
Checksum:i254CA4D38E698C9F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67P → T in AAC36743 (PubMed:11004503).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090443 mRNA. Translation: AAC36743.1.
AAFI02000012 Genomic DNA. Translation: EAL70190.1.
RefSeqiXP_643894.1. XM_638802.1.

Genome annotation databases

EnsemblProtistsiEAL70190; EAL70190; DDB_G0274595.
GeneIDi8619320.
KEGGiddi:DDB_G0274595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090443 mRNA. Translation: AAC36743.1.
AAFI02000012 Genomic DNA. Translation: EAL70190.1.
RefSeqiXP_643894.1. XM_638802.1.

3D structure databases

ProteinModelPortaliO77229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0185123.

Protein family/group databases

PeroxiBasei4096. DdKat01.

Proteomic databases

PaxDbiO77229.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL70190; EAL70190; DDB_G0274595.
GeneIDi8619320.
KEGGiddi:DDB_G0274595.

Organism-specific databases

dictyBaseiDDB_G0274595. catA.

Phylogenomic databases

eggNOGiKOG0047. Eukaryota.
COG0753. LUCA.
InParanoidiO77229.
KOiK03781.
OMAiRYNHREG.
PhylomeDBiO77229.

Enzyme and pathway databases

ReactomeiR-DDI-3299685. Detoxification of Reactive Oxygen Species.
R-DDI-6798695. Neutrophil degranulation.
R-DDI-74259. Purine catabolism.

Miscellaneous databases

PROiO77229.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATA_DICDI
AccessioniPrimary (citable) accession number: O77229
Secondary accession number(s): Q556B6, Q86A71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 4, 2007
Last modified: November 30, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.