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Protein

Crustacean hyperglycemic hormones

Gene

CHH

Organism
Macrobrachium lanchesteri (Freshwater prawn) (Palaemon lanchesteri)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hormone found in the sinus gland of isopods and decapods which controls the blood sugar level. Has a secretagogue action over the amylase released from the midgut gland. May act as a stress hormone and may be involved in the control of molting and reproduction (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Neuropeptide
Biological processCarbohydrate metabolism, Glucose metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Crustacean hyperglycemic hormones
Cleaved into the following 2 chains:
Gene namesi
Name:CHH
OrganismiMacrobrachium lanchesteri (Freshwater prawn) (Palaemon lanchesteri)
Taxonomic identifieri82204 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataCarideaPalaemonoideaPalaemonidaeMacrobrachium

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PeptideiPRO_000001904327 – 58CHH precursor-related peptideAdd BLAST32
PeptideiPRO_000001904462 – 133Crustacean hyperglycemic hormoneAdd BLAST72

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 104By similarity
Disulfide bondi84 ↔ 100By similarity
Disulfide bondi87 ↔ 113By similarity
Modified residuei133Valine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Produced by the medulla terminalis X-organ in the eyestalks and transported to the sinus gland where they are stored and released.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO77220
SMRiO77220
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.10.2010.10, 1 hit
InterProiView protein in InterPro
IPR018251 Crust_neurhormone_CS
IPR031098 Crust_neurohorm
IPR035957 Crust_neurohorm_sf
IPR001166 Hyperglycemic
IPR000346 Hyperglycemic1
PANTHERiPTHR35981 PTHR35981, 1 hit
PfamiView protein in Pfam
PF01147 Crust_neurohorm, 1 hit
PRINTSiPR00548 HYPRGLYCEMC1
PR00550 HYPRGLYCEMIC
SUPFAMiSSF81778 SSF81778, 1 hit
PROSITEiView protein in PROSITE
PS01250 CHH_MIH_GIH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRSSVMGPT MFLVVLLLIA SHQTSAWSLD GLARIEKLLS TSSSASAASP
60 70 80 90 100
TRGQALNLKK RAILDQSCKG IFDRELFKKL DRVCDDCYNL YRKPYVAIDC
110 120 130
REGCYQNLVF RQCIQDLQLM DQLDEYANAV QIVGK
Length:135
Mass (Da):15,198
Last modified:November 1, 1998 - v1
Checksum:i72BE61304FFA03DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF088854 Genomic DNA Translation: AAC36310.1

Similar proteinsi

Entry informationi

Entry nameiCHH_MACLE
AccessioniPrimary (citable) accession number: O77220
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

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