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Protein

Crustacean hyperglycemic hormones

Gene

CHH

Organism
Macrobrachium lanchesteri (Freshwater prawn) (Palaemon lanchesteri)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Hormone found in the sinus gland of isopods and decapods which controls the blood sugar level. Has a secretagogue action over the amylase released from the midgut gland. May act as a stress hormone and may be involved in the control of molting and reproduction (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone, Neuropeptide

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Crustacean hyperglycemic hormones
Cleaved into the following 2 chains:
Gene namesi
Name:CHH
OrganismiMacrobrachium lanchesteri (Freshwater prawn) (Palaemon lanchesteri)
Taxonomic identifieri82204 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataCarideaPalaemonoideaPalaemonidaeMacrobrachium

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Peptidei27 – 5832CHH precursor-related peptidePRO_0000019043Add
BLAST
Peptidei62 – 13372Crustacean hyperglycemic hormonePRO_0000019044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi68 ↔ 104By similarity
Disulfide bondi84 ↔ 100By similarity
Disulfide bondi87 ↔ 113By similarity
Modified residuei133 – 1331Valine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Produced by the medulla terminalis X-organ in the eyestalks and transported to the sinus gland where they are stored and released.

Structurei

3D structure databases

ProteinModelPortaliO77220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.10.2010.10. 1 hit.
InterProiIPR001166. Arthropod_neurhormone.
IPR031098. Arthropod_neuro/LMWP.
IPR000346. Crust_neurhormone_CHH.
IPR018251. Crust_neurhormone_CS.
[Graphical view]
PfamiPF01147. Crust_neurohorm. 1 hit.
[Graphical view]
PRINTSiPR00548. HYPRGLYCEMC1.
PR00550. HYPRGLYCEMIC.
SUPFAMiSSF81778. SSF81778. 1 hit.
PROSITEiPS01250. CHH_MIH_GIH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O77220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRSSVMGPT MFLVVLLLIA SHQTSAWSLD GLARIEKLLS TSSSASAASP
60 70 80 90 100
TRGQALNLKK RAILDQSCKG IFDRELFKKL DRVCDDCYNL YRKPYVAIDC
110 120 130
REGCYQNLVF RQCIQDLQLM DQLDEYANAV QIVGK
Length:135
Mass (Da):15,198
Last modified:November 1, 1998 - v1
Checksum:i72BE61304FFA03DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF088854 Genomic DNA. Translation: AAC36310.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF088854 Genomic DNA. Translation: AAC36310.1.

3D structure databases

ProteinModelPortaliO77220.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.2010.10. 1 hit.
InterProiIPR001166. Arthropod_neurhormone.
IPR031098. Arthropod_neuro/LMWP.
IPR000346. Crust_neurhormone_CHH.
IPR018251. Crust_neurhormone_CS.
[Graphical view]
PfamiPF01147. Crust_neurohorm. 1 hit.
[Graphical view]
PRINTSiPR00548. HYPRGLYCEMC1.
PR00550. HYPRGLYCEMIC.
SUPFAMiSSF81778. SSF81778. 1 hit.
PROSITEiPS01250. CHH_MIH_GIH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of crustacean hyperglycemic hormone (CHH) mRNA transcripts and genomic sequences in Macrobrachium lanchesteri (de Man)."
    Ju B., Khoo H.-W.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCHH_MACLE
AccessioniPrimary (citable) accession number: O77220
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: June 24, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.