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Protein
Submitted name:

Nuclear receptor 1

Gene

NR1

Organism
Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi41 – 118Nuclear receptorPROSITE-ProRule annotationAdd BLAST78

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear receptor 1Imported
Gene namesi
Name:NR1Imported
Synonyms:Ci-THRImported, nr1Imported, THRBImported
OrganismiCiona intestinalis (Transparent sea squirt) (Ascidia intestinalis)Imported
Taxonomic identifieri7719 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaEnterogonaPhlebobranchiaCionidaeCiona

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliO77154
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 118Nuclear receptorInterPro annotationAdd BLAST78
Domaini156 – 380NR LBDInterPro annotationAdd BLAST225

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOVERGENiHBG053190
KOiK08362

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

O77154-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERNQIIPNS IDCFPRHAMG RGNKDKRKNM KGYIPSYLDG NEECVVCGDK
60 70 80 90 100
ATGYHYRCIT CEGCKGFFRR TVQKDLQKTY QCKQRGKCQV NKVSRNQCQM
110 120 130 140 150
CRYEKCIATG MATDLVLNED KRIAKRKLIE RNRQLRRHKD ISHVMGTWKV
160 170 180 190 200
GRGSDDDNHV ISAVVQAHND VINDDDFEET SRSPTHGEQF SSALTNAVTR
210 220 230 240 250
VVEFAKRLPF FTGKASTDDQ VAMLKGCCME VIVLNCVASY DRARCTLKLF
260 270 280 290 300
SKVIITREKL RRTRFDHFAD DLFRTAEEMS ILQLTETEIA MLKAIIVFAA
310 320 330 340 350
DRPRIQHIDE IRNIQNSLLQ SLRYYVMDKA QHEYAVWSML LIKMADIRRI
360 370 380 390 400
SNGFAASLMD MKLNNPEELV VLFAKDRSGT SDDHTPLQDA RMDTTKTSAS
410 420 430 440 450
QKLCQKGGNK ENRMDNSKQV STSVKKESDS WPPTYKRDEP FMSNRALLLQ
460 470 480 490 500
HYGVWSCFPK PSYDLPNPSV PKPSGFQPLQ LPHAALSGHV GKTLGRNNFI
510 520 530 540 550
LPTALHPSLN TVKHLDMFRV MPVDSGEFIP SINPPAYIAN SKTNVSPQTR
560 570 580
WLLKERFTQE KGTHISDKNV HANQNATEEA INLSLKL
Length:587
Mass (Da):66,875
Last modified:November 1, 1998 - v1
Checksum:iAE5F76E67FA1E172
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077403 mRNA Translation: AAC42665.1
RefSeqiNP_001027658.1, NM_001032486.1
UniGeneiCin.23009

Genome annotation databases

GeneIDi445665
KEGGicin:445665

Similar proteinsi

Entry informationi

Entry nameiO77154_CIOIN
AccessioniPrimary (citable) accession number: O77154
Secondary accession number(s): A0A1W2VN56
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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