O77093 (O77093_CRIFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Tryparedoxin II EMBL AAC61984.1

Gene names

Name:

txnII EMBL AAC61984.1

Organism

Crithidia fasciculata EMBL AAC61984.1

Taxonomic identifier

5656 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Crithidia

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 1OC9 PDB 1FG4 PDB 1O6J PDB 1O81 PDB 1I5G PDB 1OC8
Gene Ontology (GO)
Molecular function	antioxidant activity Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O77093 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 3DBAC208A32A1F67	FASTA	165	18,786
	10 20 30 40 50 60 MYHTLLYDFR DSVPHMSGLK KFFPYSTNVL KGAAADIALP SLAGKTVFFY FSASWCPPCR 70 80 90 100 110 120 AFTPQLIDFY KAHAEKKNFE VMLISWDESA EDFKDYYAKM PWLALPFEDR KGMEFLTTGF 130 140 150 160 DVKSIPTLVG VEADSGNIIT TQARTMVVKD PEAKDFPWPN VEAKK

References

[1]	Montemartini M., Kalisz H.M., Kiess M., Nogoceke E., Singh M., Steinert P., Flohe L. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: HS6 EMBL AAC61984.1.
[2]	"Structures of tryparedoxins revealing interaction with trypanothione." Hofmann B., Budde H., Bruns K., Guerrero S.A., Kalisz H.M., Menge U., Montemartini M., Nogoceke E., Steinert P., Wissing J.B., Flohe L., Hecht H.J. Biol. Chem. 382:459-471(2001) [PubMed: 11347894] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 17-160.
[3]	"Tryparedoxins from Crithidia fasciculata and Trypanosoma brucei: photoreduction of the redox disulfide using synchrotron radiation and evidence for a conformational switch implicated in function." Alphey M.S., Gabrielsen M., Micossi E., Leonard G.A., McSweeney S.M., Ravelli R.B., Tetaud E., Fairlamb A.H., Bond C.S., Hunter W.N. J. Biol. Chem. 278:25919-25925(2003) [PubMed: 12707277] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 14-165.
[4]	"De novo phasing of two crystal forms of tryparedoxin II using the anomalous scattering from S atoms: a combination of small signal and medium resolution reveals this to be a general tool for solving protein crystal structures." Micossi E., Hunter W.N., Leonard G.A. Acta Crystallogr. D Biol. Crystallogr. 58:21-28(2002) [PubMed: 11752776] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 14-165.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF055986 Genomic DNA. Translation: AAC61984.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1FG4	X-ray	1.90	A/B	17-165	[»]
1I5G	X-ray	1.40	A	17-160	[»]
1O6J	X-ray	2.35	A/B	16-165	[»]
1O81	X-ray	1.50	A/B	14-165	[»]
1OC8	X-ray	1.50	A/B	14-165	[»]
1OC9	X-ray	2.35	A/B	14-165	[»]

ProteinModelPortal

O77093.

SMR

O77093. Positions 14-165.

ModBase

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Protocols and materials databases

StructuralBiologyKnowledgebase

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Family and domain databases

InterPro

IPR000866. AhpC/TSA.
IPR012336. Thioredoxin-like_fold.
[Graphical view]

Gene3D

G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.

Pfam

PF00578. AhpC-TSA. 1 hit.
[Graphical view]

SUPFAM

SSF52833. Thiordxn-like_fd. 1 hit.

PROSITE

PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

ProtoNet

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Entry information

Entry name

O77093_CRIFA

Accession

Primary (citable) accession number: O77093

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1998
Last sequence update:	November 1, 1998
Last modified:	October 19, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)