O77077 (O77077_PLAFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acyl carrier protein RuleBase RU000722

Gene names

Name:

acpP EMBL AAC63959.1

Organism

Plasmodium falciparum EMBL AAC63959.1

Taxonomic identifier

5833 [NCBI]

Taxonomic lineage

Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Carrier of the growing fatty acid chain in fatty acid biosynthesis By similarity. RuleBase RU000722
Sequence similarities	Contains 1 acyl carrier domain. RuleBase RU000722

Ontologies

Keywords
Biological process	Fatty acid biosynthesis RuleBase RU000722 Lipid synthesis
Domain	Signal EMBL AAC63959.1 Transit peptide EMBL AAC63959.1
Ligand	Phosphopantetheine RuleBase RU000721 PDB 2FQ0 PDB 2FQ2 PDB 3GZM
Technical term	3D-structure PDB 2FQ0 PDB 2FQ2 PDB 3GZM PDB 3GZL
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential EMBL AAC63959.1
	Transit peptide	17 – 58	42	Potential EMBL AAC63959.1
	Chain	59 – 137	79	acyl carrier protein EMBL AAC63959.1		PRO_5000053808
Sites
	Binding site	95	1	Phosphopantetheine (covalent) PDB 3GZM

Sequences

	Sequence		Length	Mass (Da)
	O77077 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: E65D46C02B97CA3C	FASTA	137	15,809
	10 20 30 40 50 60 MKILLLCIIF LYYVNAFKNT QKDGVSLQIL KKKRSNQVNF LNRKNDYNLI KNKNPSSSLK 70 80 90 100 110 120 STFDDIKKII SKQLSVEEDK IQMNSNFTKD LGADSLDLVE LIMALEEKFN VTISDQDALK 130 INTVQDAIDY IEKNNKQ

References

[1]	"Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum." Waller R.F., Keeling P.J., Donald R.G., Striepen B., Handman E., Lang-Unnasch N., Cowman A.F., Besra G.S., Roos D.S., McFadden G.I. Proc. Natl. Acad. Sci. U.S.A. 95:12352-12357(1998) [PubMed: 9770490] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 3D7 EMBL AAC63959.1.
[2]	"Plasmodium falciparum acyl carrier protein crystal structures in disulfide-linked and reduced states and their prevalence during blood stage growth." Gallagher J.R., Prigge S.T. Proteins 78:575-588(2010) [PubMed: 19768685] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 57-137 IN COMPLEX WITH PHOSPHOPANTETHEINE.
[3]	"Solution structures of conformationally equilibrium forms of holo-acyl carrier protein (PfACP) from Plasmodium falciparum provides insight into the mechanism of activation of ACPs." Sharma A.K., Sharma S.K., Surolia A., Surolia N., Sarma S.P. Biochemistry 45:6904-6916(2006) [PubMed: 16734426] [Abstract] Cited for: STRUCTURE BY NMR OF 59-137.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF038928 mRNA. Translation: AAC63959.1.

PIR

C71616.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2FQ0	NMR	-	A	59-137	[»]
2FQ2	NMR	-	A	59-137	[»]
3GZL	X-ray	2.55	A	57-137	[»]
3GZM	X-ray	1.80	A/B	57-137	[»]

ProteinModelPortal

O77077.

SMR

O77077. Positions 59-137.

ModBase

Search...

Protein-protein interaction databases

STRING

O77077.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblProtists

PFB0385w:mRNA; PFB0385w:pep; PFB0385w.

Phylogenomic databases

eggNOG

KOG1748.

PhylomeDB

O77077.

Family and domain databases

HAMAP

MF_01217. Acyl_carrier.
[Tree]

InterPro

IPR003231. Acyl_carrier.
IPR009081. Acyl_carrier_prot-like.
IPR006163. Phsphopanteth-bd.
IPR006162. PPantetheine_attach_site.
[Graphical view]

Gene3D

G3DSA:1.10.1200.10. ACP_like. 1 hit.

Pfam

PF00550. PP-binding. 1 hit.
[Graphical view]

ProDom

PD000887. PD000887. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SUPFAM

SSF47336. ACP_like. 1 hit.

TIGRFAMs

TIGR00517. Acyl_carrier. 1 hit.

PROSITE

PS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

O77077_PLAFA

Accession

Primary (citable) accession number: O77077
Secondary accession number(s): O96172

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1998
Last sequence update:	November 1, 1998
Last modified:	December 14, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)