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Protein

Amino acid transporter

Gene

Eaat1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • glutamate:sodium symporter activity Source: FlyBase
  • L-aspartate transmembrane transporter activity Source: FlyBase
  • L-glutamate transmembrane transporter activity Source: FlyBase

GO - Biological processi

  • aspartate transport Source: FlyBase
  • chemical synaptic transmission Source: FlyBase
  • determination of adult lifespan Source: FlyBase
  • larval locomotory behavior Source: FlyBase
  • L-glutamate transport Source: FlyBase
  • regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction Source: FlyBase

Keywordsi

Biological processSymportUniRule annotation, Transport

Enzyme and pathway databases

ReactomeiR-DME-210500. Glutamate Neurotransmitter Release Cycle.
R-DME-352230. Amino acid transport across the plasma membrane.
R-DME-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.

Names & Taxonomyi

Protein namesi
Recommended name:
Amino acid transporterUniRule annotation
Gene namesi
Name:Eaat1Imported
Synonyms:AF001784Imported, dEAATImported, dEAAT1Imported, dEaat1Imported, Dglt-1Imported, Dglut-1Imported, Dmel\CG3747Imported, EAATImported, EAAT1Imported, eaat1Imported
ORF Names:CG3747Imported, Dmel_CG3747Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0026439. Eaat1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 38HelicalUniRule annotationAdd BLAST19
Transmembranei59 – 83HelicalUniRule annotationAdd BLAST25
Transmembranei95 – 117HelicalUniRule annotationAdd BLAST23
Transmembranei234 – 255HelicalUniRule annotationAdd BLAST22
Transmembranei267 – 293HelicalUniRule annotationAdd BLAST27
Transmembranei372 – 395HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0026439.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0079400.

Family & Domainsi

Sequence similaritiesi

Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
GeneTreeiENSGT00760000119117.
OMAiEKAWWIS.
OrthoDBiEOG091G0UCE.

Family and domain databases

Gene3Di1.10.3860.10. 1 hit.
InterProiView protein in InterPro
IPR036458. Na-dicarbo_symporter_sf.
IPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
PfamiView protein in Pfam
PF00375. SDF. 1 hit.
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiView protein in PROSITE
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O77062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRPKQDGGK FKAFMQENVL TMATVIGVFV GGLIGFIIKN STGEWSKREI
60 70 80 90 100
MYISFPGEIF LRMLKCLIVP LLVSSITSAI GGLDLSMSSK IATRAITYYF
110 120 130 140 150
VTTISAVILG ICLVTTLRPG QGAKIVETQT ESIDKASKVL TPDTLMDLVR
160 170 180 190 200
NMFTDNIIQS TMFQHRTEIY ENTSISPAQP MENWEFKSAQ REGSNVLGLV
210 220 230 240 250
MFSVILGTTI GRMREKGQLL QDFFTTLSEA MMTITSWVIW ISPLGVAFLI
260 270 280 290 300
AAKIIEMESI AATIQSLGWY FITVMIGLFL HGFGTIAVIF FLGTRRLPYR
310 320 330 340 350
YIAKLSQVLA TAFGTGSSSA TMPLTIKCLD NMGIDPRVTR FVIPVGATIN
360 370 380 390 400
MDGTALYEAV AALFIAQYRE MSYSFGTIVA VSITATAASI GAAGIPQAGL
410 420 430 440 450
VTMVMVLDTV GLEPKDVSLI IAVDWLLDRF RTTINVMCDA LGTILVNHLS
460 470
KNDLASVDRL NAEPHELLEL GPNGHEMKE
Length:479
Mass (Da):52,359
Last modified:November 1, 1998 - v1
Checksum:i25B5772972750AB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001784 mRNA. Translation: AAD09142.1.
AF165999 mRNA. Translation: AAD47829.1.
AE014134 Genomic DNA. Translation: AAF52764.1.
AE014134 Genomic DNA. Translation: AAN10691.1.
AE014134 Genomic DNA. Translation: AAN10692.1.
BT044100 mRNA. Translation: ACH92165.1.
AE014134 Genomic DNA. Translation: ADV37001.1.
AB027469 Genomic DNA. Translation: BAA77814.1.
D86739 mRNA. Translation: BAA78032.2.
RefSeqiNP_001188751.1. NM_001201822.2.
NP_477428.1. NM_058080.4.
NP_723454.1. NM_164853.3.
NP_723455.1. NM_164854.3.
UniGeneiDm.3101.

Genome annotation databases

EnsemblMetazoaiFBtr0079800; FBpp0079400; FBgn0026439.
FBtr0079801; FBpp0079401; FBgn0026439.
FBtr0079802; FBpp0079402; FBgn0026439.
FBtr0303876; FBpp0292879; FBgn0026439.
GeneIDi34251.
KEGGidme:Dmel_CG3747.
UCSCiCG3747-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiO77062_DROME
AccessioniPrimary (citable) accession number: O77062
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 22, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported