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Protein

Amino acid transporter

Gene

Eaat1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • glutamate:sodium symporter activity Source: FlyBase
  • L-aspartate transmembrane transporter activity Source: FlyBase
  • L-glutamate transmembrane transporter activity Source: FlyBase

GO - Biological processi

  • aspartate transport Source: FlyBase
  • chemical synaptic transmission Source: FlyBase
  • determination of adult lifespan Source: FlyBase
  • larval locomotory behavior Source: FlyBase
  • L-glutamate transport Source: FlyBase
  • regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

SymportUniRule annotation, Transport

Enzyme and pathway databases

ReactomeiR-DME-210455. Astrocytic Glutamate-Glutamine Uptake And Metabolism.
R-DME-210500. Glutamate Neurotransmitter Release Cycle.
R-DME-352230. Amino acid transport across the plasma membrane.
R-DME-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.

Names & Taxonomyi

Protein namesi
Recommended name:
Amino acid transporterUniRule annotation
Gene namesi
Name:Eaat1Imported
Synonyms:Dglt-1Imported
ORF Names:CG3747Imported, Dmel_CG3747Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0026439. Eaat1.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 38HelicalUniRule annotationAdd BLAST19
Transmembranei59 – 83HelicalUniRule annotationAdd BLAST25
Transmembranei95 – 117HelicalUniRule annotationAdd BLAST23
Transmembranei234 – 255HelicalUniRule annotationAdd BLAST22
Transmembranei267 – 293HelicalUniRule annotationAdd BLAST27
Transmembranei372 – 395HelicalUniRule annotationAdd BLAST24

GO - Cellular componenti

  • integral component of membrane Source: FlyBase
  • neuron projection Source: FlyBase
  • plasma membrane Source: FlyBase
  • terminal bouton Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0026439.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0079400.

Family & Domainsi

Sequence similaritiesi

Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
GeneTreeiENSGT00760000119117.
OMAiHRTEIFE.
OrthoDBiEOG091G0UCE.

Family and domain databases

Gene3Di1.10.3860.10. 1 hit.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O77062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRPKQDGGK FKAFMQENVL TMATVIGVFV GGLIGFIIKN STGEWSKREI
60 70 80 90 100
MYISFPGEIF LRMLKCLIVP LLVSSITSAI GGLDLSMSSK IATRAITYYF
110 120 130 140 150
VTTISAVILG ICLVTTLRPG QGAKIVETQT ESIDKASKVL TPDTLMDLVR
160 170 180 190 200
NMFTDNIIQS TMFQHRTEIY ENTSISPAQP MENWEFKSAQ REGSNVLGLV
210 220 230 240 250
MFSVILGTTI GRMREKGQLL QDFFTTLSEA MMTITSWVIW ISPLGVAFLI
260 270 280 290 300
AAKIIEMESI AATIQSLGWY FITVMIGLFL HGFGTIAVIF FLGTRRLPYR
310 320 330 340 350
YIAKLSQVLA TAFGTGSSSA TMPLTIKCLD NMGIDPRVTR FVIPVGATIN
360 370 380 390 400
MDGTALYEAV AALFIAQYRE MSYSFGTIVA VSITATAASI GAAGIPQAGL
410 420 430 440 450
VTMVMVLDTV GLEPKDVSLI IAVDWLLDRF RTTINVMCDA LGTILVNHLS
460 470
KNDLASVDRL NAEPHELLEL GPNGHEMKE
Length:479
Mass (Da):52,359
Last modified:November 1, 1998 - v1
Checksum:i25B5772972750AB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001784 mRNA. Translation: AAD09142.1.
AF165999 mRNA. Translation: AAD47829.1.
AE014134 Genomic DNA. Translation: AAF52764.1.
AE014134 Genomic DNA. Translation: AAN10691.1.
AE014134 Genomic DNA. Translation: AAN10692.1.
BT044100 mRNA. Translation: ACH92165.1.
AE014134 Genomic DNA. Translation: ADV37001.1.
AB027469 Genomic DNA. Translation: BAA77814.1.
D86739 mRNA. Translation: BAA78032.2.
RefSeqiNP_001188751.1. NM_001201822.2.
NP_477428.1. NM_058080.4.
NP_723454.1. NM_164853.3.
NP_723455.1. NM_164854.3.
UniGeneiDm.3101.

Genome annotation databases

EnsemblMetazoaiFBtr0079800; FBpp0079400; FBgn0026439.
FBtr0079801; FBpp0079401; FBgn0026439.
FBtr0079802; FBpp0079402; FBgn0026439.
FBtr0303876; FBpp0292879; FBgn0026439.
GeneIDi34251.
KEGGidme:Dmel_CG3747.
UCSCiCG3747-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001784 mRNA. Translation: AAD09142.1.
AF165999 mRNA. Translation: AAD47829.1.
AE014134 Genomic DNA. Translation: AAF52764.1.
AE014134 Genomic DNA. Translation: AAN10691.1.
AE014134 Genomic DNA. Translation: AAN10692.1.
BT044100 mRNA. Translation: ACH92165.1.
AE014134 Genomic DNA. Translation: ADV37001.1.
AB027469 Genomic DNA. Translation: BAA77814.1.
D86739 mRNA. Translation: BAA78032.2.
RefSeqiNP_001188751.1. NM_001201822.2.
NP_477428.1. NM_058080.4.
NP_723454.1. NM_164853.3.
NP_723455.1. NM_164854.3.
UniGeneiDm.3101.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0079400.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079800; FBpp0079400; FBgn0026439.
FBtr0079801; FBpp0079401; FBgn0026439.
FBtr0079802; FBpp0079402; FBgn0026439.
FBtr0303876; FBpp0292879; FBgn0026439.
GeneIDi34251.
KEGGidme:Dmel_CG3747.
UCSCiCG3747-RA. d. melanogaster.

Organism-specific databases

CTDi34251.
FlyBaseiFBgn0026439. Eaat1.

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
GeneTreeiENSGT00760000119117.
OMAiHRTEIFE.
OrthoDBiEOG091G0UCE.

Enzyme and pathway databases

ReactomeiR-DME-210455. Astrocytic Glutamate-Glutamine Uptake And Metabolism.
R-DME-210500. Glutamate Neurotransmitter Release Cycle.
R-DME-352230. Amino acid transport across the plasma membrane.
R-DME-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.

Miscellaneous databases

GenomeRNAii34251.

Gene expression databases

BgeeiFBgn0026439.

Family and domain databases

Gene3Di1.10.3860.10. 1 hit.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO77062_DROME
AccessioniPrimary (citable) accession number: O77062
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.