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Protein

Carboxylic ester hydrolase

Gene

ChE2

Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotationImported

Protein family/group databases

ESTHERibrafl-ACHE2. AChE.
MEROPSiS09.980.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylic ester hydrolaseUniRule annotation (EC:3.1.1.-UniRule annotation)
Gene namesi
Name:ChE2Imported
OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)Imported
Taxonomic identifieri7739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525UniRule annotationAdd
BLAST
Chaini26 – 602577Carboxylic ester hydrolaseUniRule annotationPRO_5005142283Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7739.JGI273173.

Structurei

3D structure databases

ProteinModelPortaliO76999.
SMRiO76999. Positions 32-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 549520COesteraseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG4389. Eukaryota.
COG2272. LUCA.
HOVERGENiHBG008839.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76999-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAMREYWFF VLLVNLTAHT WTAEAQTTNG PIVTTLQGRL QGKVLDVGGR
60 70 80 90 100
TVNAFLGIPY GAPPVGPRRF KPPIAAEPWN GIYNASSYPN TCMQLPDTTF
110 120 130 140 150
PGYKGAEMWN PNTPVSEDCL YLNVWQPSPV PVGATVMVWI YGGGFMSGTS
160 170 180 190 200
SLDVYDGRYL ARTQGVIVAS MNYRTGAMGF LSLGNSEAPG NVGLMDQNLA
210 220 230 240 250
LTWIKENVAS FGGAPNKVSI FGESAGAASV SYHLLSPMSK NLFQRAIMES
260 270 280 290 300
ASAPSPWALL SDTEAYRRGI ELPKAVGCST DSDLEETIEC MRGVPAQTIS
310 320 330 340 350
DNEWVVWGLC QFPFAPIVDG NFIREHPTQS LQTGNLKQTD VLVGFNNDEG
360 370 380 390 400
VYFLLYGAPG FSKDTRSLIT REQYLEGIKM SVMGINDISV DALSFQYIDW
410 420 430 440 450
VNFDQPSMYR DAIDDLSGDY NFICPALSFG KAMASLGRKT YQYKFVHQAS
460 470 480 490 500
NMPWPKWTGV MHGYECEFVF GLPTDQKNNY TQEEAVFATQ IMTYWANFAK
510 520 530 540 550
TGNPNKQTLE DPAPDVWRPY TDEGQEYLIL DVGGNRMANG PRSKSCAFWD
560 570 580 590 600
NYLWELDRKT DDLMEQAQSC TNGAEIPRAS TCTAIFSTAI LLLLLNSATT

LL
Length:602
Mass (Da):66,491
Last modified:November 1, 1998 - v1
Checksum:i1D29ABF76618C2EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74381 mRNA. Translation: AAD05374.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74381 mRNA. Translation: AAD05374.1.

3D structure databases

ProteinModelPortaliO76999.
SMRiO76999. Positions 32-554.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7739.JGI273173.

Protein family/group databases

ESTHERibrafl-ACHE2. AChE.
MEROPSiS09.980.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG4389. Eukaryota.
COG2272. LUCA.
HOVERGENiHBG008839.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning, in vitro expression, and biochemical characterization of cholinesterase 1 and cholinesterase 2 from amphioxus--comparison with cholinesterase 1 and cholinesterase 2 produced in vivo."
    McClellan J.S., Coblentz W.B., Sapp M., Rulewicz G., Gaines D.I., Hawkins A., Ozment C., Bearden A., Merritt S., Cunningham J., Palmer E., Contractor A., Pezzementi L.
    Eur. J. Biochem. 258:419-429(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO76999_BRAFL
AccessioniPrimary (citable) accession number: O76999
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.