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Protein

Tyrosine-protein kinase

Gene
N/A
Organism
Sycon raphanus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei742 – 7421Proton acceptorUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
OrganismiSycon raphanusImported
Taxonomic identifieri56443 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPoriferaCalcareaCalcaroneaLeucosolenidaSycettidaeSycon

Structurei

3D structure databases

ProteinModelPortaliO76978.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 271265F-BARInterPro annotationAdd
BLAST
Domaini517 – 60589SH2InterPro annotationAdd
BLAST
Domaini620 – 879260Protein kinaseInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili322 – 34928Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.UniRule annotation
Contains F-BAR domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR016250. Tyr-prot_kinase_Fes/Fps.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF197. PTHR24418:SF197. 2 hits.
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PIRSFiPIRSF000632. TyrPK_fps. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00055. FCH. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEQDECNFG TDLITRAGSE ALLRLNDEEI RLLESMKTYM TKRAKADQDY
60 70 80 90 100
AKELLRLRVD RSTGGALHRS DSTSAEETSP ILKAWHQFQA ETDRVSSLIA
110 120 130 140 150
QHAQALNAIT VQSVDKLLLN KKTAKKRFTT CRQDADAAYG RTTERVNKLK
160 170 180 190 200
KSYQQLSADV SRKKTEFQKS VGSPNQQDKM KRYIRAADKL CKCHNDYLLA
210 220 230 240 250
LQEVQEHQEA YRTRILPLLL NNMQQVCQGH AQQWMDALND SLDNIDSCRD
260 270 280 290 300
EYREIFSRLH ATLGDLDPSS EYNGFLERNG EKLPPAEKFT FDVKLLEHAP
310 320 330 340 350
EHASPDHLII NNLTQPQLES SITTMNSQLE ELKKTLQTKT DELEVVRNTE
360 370 380 390 400
VDENATTAEQ MDQHMSTLGK YSDISLEVEQ LWLNQTKLEL AINTMESSLT
410 420 430 440 450
SLGGQPAPLF DESVGNVDQQ MLDHAEQVNG GGDQTAAAHP TSTKLFSAML
460 470 480 490 500
GGVKSMKNKV KKKALKMKTS MTATSHAQSS NLAVSSSPCG DMEDEFDDED
510 520 530 540 550
VEYDTPEAHA GVEEEPWYHG EISRQEATGL LKKMGDFLVR YSADKEHYTL
560 570 580 590 600
TVKMEGIKHF IIQHNEEGFR FEGDPYPSIP MLIDHHFKNR LPVTRKSQAI
610 620 630 640 650
LRQPVKKPDL REYNISHDNI LIGEKIGKGN FGDVFKGYLK THNMEVAVKS
660 670 680 690 700
CRSEDFPDKQ KFLQEAEILK QYRHPNIVEL IGVCAEKEPL YIIMELMAGG
710 720 730 740 750
NFLSFLRGPE GKRLKVNNLT EMCVEAAAGM VFLEQRNCIH RDLAARNCLV
760 770 780 790 800
GDNNVLKISD FGMSREEDDG IYTVSSGLKQ IPIKWTSPEA LNYGRYTTQS
810 820 830 840 850
DVWSYGILLW ETYTYGSGPY PGMNNRETRE RIESNYRMPR PELCPHPVYK
860 870
LMLSCWEYDP DKRPSFAEIY DKLYSFNHQ
Length:879
Mass (Da):100,057
Last modified:November 1, 1998 - v1
Checksum:iED8430BB76DACCF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17051 mRNA. Translation: CAA76605.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17051 mRNA. Translation: CAA76605.1.

3D structure databases

ProteinModelPortaliO76978.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR016250. Tyr-prot_kinase_Fes/Fps.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF197. PTHR24418:SF197. 2 hits.
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PIRSFiPIRSF000632. TyrPK_fps. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00055. FCH. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization and phylogenetic analysis of a cDNA encoding the Fes/FER related, non-receptor protein-tyrosine kinase in the marine sponge sycon raphanus."
    Cetkovic H., Muller I.M., Muller W.E., Gamulin V.
    Gene 216:77-84(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO76978_9METZ
AccessioniPrimary (citable) accession number: O76978
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.