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Protein

Homeobox protein orthopedia

Gene

OTP

Organism
Paracentrotus lividus (Common sea urchin)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in larval skeletal patterning.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi116 – 17560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein orthopedia
Alternative name(s):
Orthopedia-related
PlOtp
Gene namesi
Name:OTP
OrganismiParacentrotus lividus (Common sea urchin)
Taxonomic identifieri7656 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaEchinidaeParacentrotus

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Homeobox protein orthopediaPRO_0000049205Add
BLAST

Expressioni

Tissue specificityi

Expressed at low levels in lantern and tubefeet.1 Publication

Developmental stagei

Expression starts at the gastrula stage, increases at the prism stage and peaks at the puteus larva stage. Expression is restricted to the oral epithelium.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO76971.
SMRiO76971. Positions 115-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi344 – 35714OARPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi79 – 9113Poly-GlyAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERTLAHVPS MELSTEALLV TGGLDNTNKM ISSSAVRNDD GTMISQHSDK
60 70 80 90 100
VSYGTSGAPD GSTPPYPAGG VGEGNGIVGG GGGGGGGGGG GMVGDGTGHS
110 120 130 140 150
VGSSGSGNDD DKPAKQKRHR TRFTPAQLNE LERNFAKTHY PDIFMREEIA
160 170 180 190 200
MRVGLTESRV QVWFQNRRAK WKKRKKTTNV FRTPGALLPS HGLAQFPSPM
210 220 230 240 250
NDSFCNFHGQ DTRGWPAMSG MTTHMAPHMT THMPSHQMPL MGGGPGSALA
260 270 280 290 300
LPPSLPRQGL GQSMQQQSVN CSMGQTTGLN TLSMGTNGSM GSMTSMYQPS
310 320 330 340 350
LGGMTTGSMS SGLSSPSPPN LPVTDSSTDL SCSVSDAGDM WRGTSIASLR
360
RKLEHAASLN GIFR
Length:364
Mass (Da):38,133
Last modified:November 1, 1998 - v1
Checksum:i86658CCDD4D17E64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007501 mRNA. Translation: CAA07543.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007501 mRNA. Translation: CAA07543.1.

3D structure databases

ProteinModelPortaliO76971.
SMRiO76971. Positions 115-173.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOTP_PARLI
AccessioniPrimary (citable) accession number: O76971
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.