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Protein

Homeobox protein orthopedia

Gene

OTP

Organism
Paracentrotus lividus (Common sea urchin)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in larval skeletal patterning.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi116 – 175HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein orthopedia
Alternative name(s):
Orthopedia-related
PlOtp
Gene namesi
Name:OTP
OrganismiParacentrotus lividus (Common sea urchin)
Taxonomic identifieri7656 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaEchinidaeParacentrotus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492051 – 364Homeobox protein orthopediaAdd BLAST364

Proteomic databases

PRIDEiO76971

Expressioni

Tissue specificityi

Expressed at low levels in lantern and tubefeet.1 Publication

Developmental stagei

Expression starts at the gastrula stage, increases at the prism stage and peaks at the puteus larva stage. Expression is restricted to the oral epithelium.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO76971
SMRiO76971
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi344 – 357OARPROSITE-ProRule annotationAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi79 – 91Poly-GlyAdd BLAST13

Sequence similaritiesi

Keywords - Domaini

Homeobox

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR000047 HTH_motif
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit

Sequencei

Sequence statusi: Complete.

O76971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERTLAHVPS MELSTEALLV TGGLDNTNKM ISSSAVRNDD GTMISQHSDK
60 70 80 90 100
VSYGTSGAPD GSTPPYPAGG VGEGNGIVGG GGGGGGGGGG GMVGDGTGHS
110 120 130 140 150
VGSSGSGNDD DKPAKQKRHR TRFTPAQLNE LERNFAKTHY PDIFMREEIA
160 170 180 190 200
MRVGLTESRV QVWFQNRRAK WKKRKKTTNV FRTPGALLPS HGLAQFPSPM
210 220 230 240 250
NDSFCNFHGQ DTRGWPAMSG MTTHMAPHMT THMPSHQMPL MGGGPGSALA
260 270 280 290 300
LPPSLPRQGL GQSMQQQSVN CSMGQTTGLN TLSMGTNGSM GSMTSMYQPS
310 320 330 340 350
LGGMTTGSMS SGLSSPSPPN LPVTDSSTDL SCSVSDAGDM WRGTSIASLR
360
RKLEHAASLN GIFR
Length:364
Mass (Da):38,133
Last modified:November 1, 1998 - v1
Checksum:i86658CCDD4D17E64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007501 mRNA Translation: CAA07543.1

Similar proteinsi

Entry informationi

Entry nameiOTP_PARLI
AccessioniPrimary (citable) accession number: O76971
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

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