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Protein
Submitted name:

Calreticulin

Gene

crt

Organism
Necator americanus (Human hookworm)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061CarbohydrateUniRule annotation
Binding sitei108 – 1081CarbohydrateUniRule annotation
Binding sitei125 – 1251CarbohydrateUniRule annotation
Binding sitei132 – 1321CarbohydrateUniRule annotation
Binding sitei313 – 3131CarbohydrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ChaperoneUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
CalreticulinImported
Gene namesi
Name:crtImported
OrganismiNecator americanus (Human hookworm)Imported
Taxonomic identifieri51031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaStrongylidaAncylostomatoideaAncylostomatidaeBunostominaeNecator

Subcellular locationi

  • Endoplasmic reticulum SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020UniRule annotationAdd
BLAST
Chaini21 – 403383UniRule annotationPRO_5004159818Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO76961.
SMRiO76961. Positions 202-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili349 – 40254Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the calreticulin family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalUniRule annotation

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009169. Calreticulin.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 2 hits.
[Graphical view]
PIRSFiPIRSF002356. Calreticulin. 1 hit.
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76961-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSLVALLPV LCIAVAEVYF KEEFLDDSWK ERWVQSKHKS DYGEFVLSAG
60 70 80 90 100
KYFGDATRDQ GMKTSQDAKF YSRAAKFPKA FSNKGKTVVI QFTVKHEQGI
110 120 130 140 150
DCGGGYVKVM SSDVDLSDFH GETPYNVMFG PDICGPTKKV HDIFSYKGKN
160 170 180 190 200
HLIKKDIRCK DDELTHLYTL ILNPDNTYEV QIDGEKVESG ELESDWDLLP
210 220 230 240 250
PKKIKDPDAK KPEDWDEREY IDDADDKKPE DWDKPEHIPD PDAKKPDDWD
260 270 280 290 300
DEMDGEWEPP MIDNPEYKGE WKPKQIKNPA YKGKWIHPEI DNPEYTPDDE
310 320 330 340 350
LYLYKDWGAI GFDLWQVKSG TIFDNVLVSD SVDEAKAHAA ETFEKLKPVE
360 370 380 390 400
KELKEKADEE NRKKMEEEAK KQEEEEKKKK EKEEKEEKED EDEEKADEGH

EEL
Length:403
Mass (Da):46,833
Last modified:November 1, 1998 - v1
Checksum:i21F38B0515487B6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006790 mRNA. Translation: CAA07254.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006790 mRNA. Translation: CAA07254.1.

3D structure databases

ProteinModelPortaliO76961.
SMRiO76961. Positions 202-298.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009169. Calreticulin.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 2 hits.
[Graphical view]
PIRSFiPIRSF002356. Calreticulin. 1 hit.
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Berry C.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "A hookworm allergen which strongly resembles calreticulin."
    Pritchard D.I., Brown A., Kasper G., McElroy P., Loukas A., Hewitt C., Berry C., Fullkrug R., Beck E.
    Parasite Immunol. 20:0-0(0)
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO76961_NECAM
AccessioniPrimary (citable) accession number: O76961
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.